The ins and outs of lipid rafts: functions in intracellular cholesterol homeostasis, microparticles, and cell membranes

Autor: Amber B. Ouweneel, Michael J. Thomas, Mary G. Sorci-Thomas

Publikováno v: Journal of Lipid Research, Vol 61, Iss 5, Pp 676-686 (2020)

Cellular membranes are not homogenous mixtures of proteins; rather, they are segregated into microdomains on the basis of preferential association between specific lipids and proteins. These microdomains, called lipid rafts, are well known for their

Externí odkaz: https://doaj.org/article/dfb4256ef0314f3a822fb0f9f232b19d

Apolipoprotein A1 deficiency in mice primes bone marrow stem cells for T cell lymphopoiesis

Autor: Ezra J. van der Wel, Myrthe E. Reiche, Olga S.C. Snip, Robbert Wever, Miranda Van Eck, Menno Hoekstra, Amber B. Ouweneel, Esther Lutgens, Soňa Kauerova, Frank H. Schaftenaar

Publikováno v: Journal of cell science, 135(5):jcs25890. Company of Biologists Ltd
Journal of Cell Science, 135(5)
Journal of Cell Science
article-version (VoR) Version of Record
Journal of Cell Science, 135(5):jcs.258901. COMPANY BIOLOGISTS LTD

The bone marrow has emerged as a potentially important target in cardiovascular disease as it generates all leukocytes involved in atherogenesis. In the current study, we evaluated whether a change in bone marrow functionality underlies the increased

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab2748ff7a0efa0b00583bd871b00b06
https://hdl.handle.net/1887/3505572

SR-BI deficiency disassociates obesity from hepatic steatosis and glucose intolerance development in high fat diet-fed mice

Autor: Amber B. Ouweneel, Joya E. Nahon, Janine J. Geerling, Ronald J. van der Sluis, Rick van der Geest, Juliet Price, Miranda Van Eck, Menno Hoekstra

Publikováno v: Journal of Nutritional Biochemistry, 89, 108564

Scavenger receptor BI (SR-BI) has been suggested to modulate adipocyte function. To uncover the potential relevance of SR-BI for the development of obesity and associated metabolic complications, we compared the metabolic phenotype of wild-type and S

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::747daeaa5f94a2da4da4f21475cbdc80
https://doi.org/10.1016/j.jnutbio.2020.108564

Apolipoprotein A1 modulates the ability of bone marrow to facilitate lymphocyte production after transplantation into Ldl receptor knockout mice

Autor: M. Van Eck, Frank H. Schaftenaar, Olga S.C. Snip, Robbert Wever, Menno Hoekstra, Amber B. Ouweneel, S. Cejkova

Apolipoprotein A1 (APOA1) deficiency is associated with severe reductions in plasma HDL cholesterol and therefore an increased atherosclerosis susceptibility. Although APOA1 can directly impact on inflammation and atherosclerosis, it can also suppres

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::901e160b2fcccc63fb7b3d2926e275aa
http://hdl.handle.net/1887/3198977

Hypercholesterolemia impairs megakaryopoiesis and platelet production in scavenger receptor BI knockout mice

Autor: Ezra J. van der Wel, Menno Hoekstra, Jasmin Hassan, Olga S.C. Snip, Miranda Van Eck, Suzanne J.A. Korporaal, Amber B. Ouweneel, Frank H. Schaftenaar

Publikováno v: Atherosclerosis, 282, 176. Elsevier

Background and aims: Thrombocytopenia in scavenger receptor BI (SR-BI) knockout mice is suggested to result from augmented platelet clearance induced by elevated intracellular unesterified cholesterol (UC) levels. We hypothesize that SR-BI deficiency

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c5f5cc43d3a5ebe8da8472c2f38927a
https://hdl.handle.net/1887/3203171