Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Amber B Azam"'
ADVANCED IN VIVO USE OF CRISPR/CAS9 AND ANTI-SENSE DNA INHIBITION FOR GENE MANIPULATION IN THE BRAIN
Publikováno v:
Frontiers in Genetics, Vol 6 (2016)
Gene-editing tools are essential for uncovering how genes mediate normal brain-behaviour relationships and contribute to neurodegenerative and neuropsychiatric disorders. Recent progress in gene-editing technology is now allowing neuroscientists unpr
Externí odkaz:
https://doaj.org/article/f984633321e64528ae437c63f0efb69e
Autor:
Donglai Ma, M. Firoz Mian, David Morgan, Craig P. Hutton, Minesh Kapadia, Chuanhai Cao, Boris Sakic, Klotilda Narkaj, Iva B. Zovkic, Bernadeta Michalski, Breanna Brown, Margaret Fahnestock, Amber B. Azam, Paul Forsythe
Publikováno v:
Alzheimer’s Research & Therapy, Vol 13, Iss 1, Pp 1-22 (2021)
Alzheimer's Research & Therapy
Alzheimer's Research & Therapy
Background Circulating autoantibodies and sex-dependent discrepancy in prevalence are unexplained phenomena of Alzheimer’s disease (AD). Using the 3xTg-AD mouse model, we reported that adult males show early manifestations of systemic autoimmunity,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d52a36103ff3132113f0ad626b0f2663
https://doi.org/10.21203/rs.3.rs-60074/v1
https://doi.org/10.21203/rs.3.rs-60074/v1
Autor:
Andrew J. Kennedy, Caroline P. Gettens, Brandon J. Walters, Pascale Bouchard-Cannon, Klotilda Narkaj, Gilda Stefanelli, Mark A. Brimble, Hai-Ying M. Cheng, Jeremy J. Day, Iva B. Zovkic, Andrew M. Davidoff, Amber B. Azam
Publikováno v:
Cell Reports, Vol 22, Iss 5, Pp 1124-1131 (2018)
Summary: Histone variants were recently discovered to regulate neural plasticity, with H2A.Z emerging as a memory suppressor. Using whole-genome sequencing of the mouse hippocampus, we show that basal H2A.Z occupancy is positively associated with ste
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::081f8ffa1b882b11eade0881ea820c07
http://www.sciencedirect.com/science/article/pii/S2211124718300378
http://www.sciencedirect.com/science/article/pii/S2211124718300378
Publikováno v:
Innovation in Aging
Background and Objectives Depression is an important risk factor for Alzheimer’s disease (AD) but little is known about the mechanisms of this association. Given sex differences in both AD and depression, we sought to conduct a systematic review an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c51fbd85807841c610fe34cc684ed7f3
https://doi.org/10.1093/geroni/igz015
https://doi.org/10.1093/geroni/igz015
Publikováno v:
Hormones and behavior. 106
Although sex-hormones have a well-documented role in memory formation, most literature has focused on estrogens, whereas the role of androgens and their receptor (the androgen receptor; AR) in fear memory is relatively unexplored. To address this gap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec7cece6946acfda924989e0dd4b80e6
https://pubmed.ncbi.nlm.nih.gov/30172646
https://pubmed.ncbi.nlm.nih.gov/30172646
Autor:
Minesh Kapadia, Salwierz P, Christopher A, Donglai Ma, Elyse Rosa, Bernadeta Michalski, Margaret Fahnestock, Boris Sakic, Paul Forsythe, Iva B. Zovkic, Mian Mf, Amber B. Azam
Publikováno v:
Journal of Alzheimer's disease : JAD. 63(3)
The triple-transgenic (3xTg-AD) mouse strain is a valuable model of Alzheimer's disease (AD) because it develops both amyloid-β (Aβ) and tau brain pathology. However, 1-year-old 3xTg-AD males no longer show plaques and tangles, yet early in life th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::855796ee66c33628185eea1157628652
https://pubmed.ncbi.nlm.nih.gov/29710702
https://pubmed.ncbi.nlm.nih.gov/29710702
Autor:
Firyal Ramzan, Amber B. Azam, Brandon J. Walters, Klotilda Narkaj, Iva B. Zovkic, Malak Wahdan, Carl Frank David Steininger, Gilda Stefanelli
Publikováno v:
eNeuro
Memory formation is a protracted process that initially involves the hippocampus and becomes increasingly dependent on the cortex over time, but the mechanisms of this transfer are unclear. We recently showed that hippocampal depletion of the histone
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5d65e21bef3684bb30f645984a9e9cf
https://doi.org/10.1523/eneuro.0378-18.2018
https://doi.org/10.1523/eneuro.0378-18.2018
Autor:
Gilda Stefanelli, Amber B. Azam, Brandon J. Walters, Mark A. Brimble, Caroline P. Gettens, Pascale Bouchard-Cannon, Hai-Ying M. Cheng, Andrew M. Davidoff, Klotilda Narkaj, Jeremy J. Day, Andrew J. Kennedy, Iva B. Zovkic
Publikováno v:
Cell Reports, Vol 22, Iss 5, Pp 1124-1131 (2018)
Summary: Histone variants were recently discovered to regulate neural plasticity, with H2A.Z emerging as a memory suppressor. Using whole-genome sequencing of the mouse hippocampus, we show that basal H2A.Z occupancy is positively associated with ste
Externí odkaz:
https://doaj.org/article/9c12da0205304d89b9ae92c1b0d9e7ab