Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Amber, Lockridge"'
Autor:
Amber Lockridge, John A. Hanover
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2022)
Although traditionally considered a glucose metabolism-associated modification, the O-linked β-N-Acetylglucosamine (O-GlcNAc) regulatory system interacts extensively with lipids and is required to maintain lipid homeostasis. The enzymes of O-GlcNAc
Externí odkaz:
https://doaj.org/article/2d252fb2a7d842a385786f7854bec4df
Autor:
Amber Lockridge, Seokwon Jo, Eric Gustafson, Niklas Damberg, Ramkumar Mohan, Miranda Olson, Juan E. Abrahante, Emilyn U. Alejandro
Publikováno v:
Cell Reports, Vol 31, Iss 5, Pp - (2020)
Summary: During early obesity, pancreatic β cells compensate for increased metabolic demand through a transient phase of insulin hypersecretion that stabilizes blood glucose and forestalls diabetic progression. We find evidence that β cell O-GlcNAc
Externí odkaz:
https://doaj.org/article/c85a91f350514adc99fa3f058ddfc74f
Autor:
Ramkumar Mohan, Seokwon Jo, Elina Da Sol Chung, Eunice Oribamise, Amber Lockridge, Juan E. Abrahante-Lloréns, Hai-Bin Ruan, Xiao-Yong Yang, Emilyn U. Alejandro
Publikováno v:
Cells, Vol 10, Iss 10, p 2801 (2021)
The nutrient-sensor O-GlcNAc transferase (Ogt), the sole enzyme that adds an O-GlcNAc-modification onto proteins, plays a critical role for pancreatic β-cell survival and insulin secretion. We hypothesized that β-cell Ogt overexpression would confe
Externí odkaz:
https://doaj.org/article/96bd25cb755c4432b74adb896f3ea59e
Publikováno v:
Cells, Vol 10, Iss 1, p 93 (2021)
Insulin-secreting pancreatic β-cells express proteins characteristic of D-serine regulated synapses, but the acute effect of D-serine co-agonism on its presumptive β-cell target, N-methyl D-aspartate receptors (NMDARs), is unclear. We used multiple
Externí odkaz:
https://doaj.org/article/c26fbd05da9344e39d9295cb18b2a4e1
Autor:
Emilyn U. Alejandro, Eric Gustafson, Ahmad Essawy, Neha Panigrahy, Regina Schlichting, Nicholas Esch, Ramkumar Mohan, Amber Lockridge, Seokwon Jo, Ada Admin
Protein translation is essential for cell physiology, and dysregulation of this process has been linked to aging-related diseases such as type 2 diabetes. Reduced protein level of a requisite scaffolding protein of the initiation complex, eIF4G1, dow
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cceadce74dfc93e42cc0dd51ccf4bec7
https://doi.org/10.2337/figshare.13110335.v1
https://doi.org/10.2337/figshare.13110335.v1
Publikováno v:
J Biol Chem
An early hallmark of type 2 diabetes is a failure of proinsulin-to-insulin processing in pancreatic β-cells, resulting in hyperproinsulinemia. Proinsulin processing is quite sensitive to nutrient flux, and β-cell–specific deletion of the nutrient
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::349f05b9563bdeb4d8c3a7278ae36ee1
https://pubmed.ncbi.nlm.nih.gov/31300553
https://pubmed.ncbi.nlm.nih.gov/31300553
Publikováno v:
Placenta. 83:e12
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::972356331ce4045f4291d2b0416deddf
https://doi.org/10.1016/j.placenta.2019.06.045
https://doi.org/10.1016/j.placenta.2019.06.045