A single mutation in Taiwanese H6N1 influenza hemagglutinin switches binding to human‐type receptors

Autor: de Vries, Robert P, Tzarum, Netanel, Peng, Wenjie, Thompson, Andrew J, Ambepitiya Wickramasinghe, Iresha N, de la Pena, Alba T Torrents, van Breemen, Marielle J, Bouwman, Kim M, Zhu, Xueyong, McBride, Ryan, Yu, Wenli, Sanders, Rogier W, Verheije, Monique H, Wilson, Ian A, Paulson, James C, Afd Chemical Biology and Drug Discovery, LS Pathologie, Chemical Biology and Drug Discovery

Publikováno v: EMBO Molecular Medicine
EMBO Journal, 9(9), 1314. Nature Publishing Group
EMBO molecular medicine, 9(9), 1314-1325. Wiley-Blackwell

In June 2013, the first case of human infection with an avian H6N1 virus was reported in a Taiwanese woman. Although this was a single non-fatal case, the virus continues to circulate in Taiwanese poultry. As with any emerging avian virus that infect

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::130858be093efe8ddff0da630f1aa748
https://doi.org/10.15252/emmm.201707726

Three mutations switch H7N9 influenza to human-type receptor specificity

Autor: de Vries, Robert P, Peng, Wenjie, Grant, Oliver C, Thompson, Andrew J, Zhu, Xueyong, Bouwman, Kim M, de la Pena, Alba T Torrents, van Breemen, Marielle J, Ambepitiya Wickramasinghe, Iresha N, de Haan, Cornelis A M, Yu, Wenli, McBride, Ryan, Sanders, Rogier W, Woods, Robert J, Verheije, Monique H, Wilson, Ian A, Paulson, James C, dI&I I&I-1, Afd Chemical Biology and Drug Discovery, dPB I&I

Publikováno v: PLoS pathogens, 13(6). Public Library of Science
PLoS Pathogens, 13(6). Public Library of Science
PLoS Pathogens, Vol 13, Iss 6, p e1006390 (2017)
PLoS Pathogens

The avian H7N9 influenza outbreak in 2013 resulted from an unprecedented incidence of influenza transmission to humans from infected poultry. The majority of human H7N9 isolates contained a hemagglutinin (HA) mutation (Q226L) that has previously been

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef05cef5f6e0915f4c4842738fdcce7f
https://pure.amc.nl/en/publications/three-mutations-switch-h7n9-influenza-to-humantype-receptor-specificity(3b2fe162-a142-4f5f-8f75-51d2c20512c4).html

Three mutations switch H7N9 influenza to human-type receptor specificity.

Autor: de Vries RP; Departments of Molecular Medicine, & Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, United States of America.; Department of Chemical Biology and Drug Discovery, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, CG Utrecht, The Netherlands., Peng W; Departments of Molecular Medicine, & Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, United States of America., Grant OC; Complex Carbohydrate Research Center, University of Georgia, Athens, GA, United States of America., Thompson AJ; Departments of Molecular Medicine, & Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, United States of America., Zhu X; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, United States of America., Bouwman KM; Pathology Division, Department of Pathobiology, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 1, CL Utrecht, The Netherlands., de la Pena ATT; Department of Medical Microbiology, Academic Medical Center, University of Amsterdam, AZ Amsterdam, The Netherlands., van Breemen MJ; Department of Medical Microbiology, Academic Medical Center, University of Amsterdam, AZ Amsterdam, The Netherlands., Ambepitiya Wickramasinghe IN; Pathology Division, Department of Pathobiology, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 1, CL Utrecht, The Netherlands., de Haan CAM; Virology Division, Department of Infectious Diseases & Immunology, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 1,CL Utrecht, The Netherlands., Yu W; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, United States of America., McBride R; Departments of Molecular Medicine, & Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, United States of America., Sanders RW; Department of Medical Microbiology, Academic Medical Center, University of Amsterdam, AZ Amsterdam, The Netherlands.; Department of Microbiology and Immunology, Weil Medical College of Cornell University, New York, NY, United States of America., Woods RJ; Complex Carbohydrate Research Center, University of Georgia, Athens, GA, United States of America., Verheije MH; Pathology Division, Department of Pathobiology, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 1, CL Utrecht, The Netherlands., Wilson IA; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, United States of America.; Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA, United States of America., Paulson JC; Departments of Molecular Medicine, & Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, United States of America.

Publikováno v: PLoS pathogens [PLoS Pathog] 2017 Jun 15; Vol. 13 (6), pp. e1006390. Date of Electronic Publication: 2017 Jun 15 (Print Publication: 2017).