Isotype switching in human memory B cells sets intrinsic antigen-affinity thresholds that dictate antigen-driven fates.

Autor: Ambegaonkar AA; Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, NIH, Rockville, MD 20852., Holla P; Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, NIH, Rockville, MD 20852., Sohn H; Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, NIH, Rockville, MD 20852., George R; Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, NIH, Rockville, MD 20852., Tran TM; Division of Infectious Diseases, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202., Pierce SK; Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, NIH, Rockville, MD 20852.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2024 Mar 26; Vol. 121 (13), pp. e2313672121. Date of Electronic Publication: 2024 Mar 19.

Shared transcriptional profiles of atypical B cells suggest common drivers of expansion and function in malaria, HIV, and autoimmunity.

Autor: Holla P; Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, USA., Dizon B; National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, USA., Ambegaonkar AA; Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, USA., Rogel N; Department of Pathology, Sackler School of Medicine, Tel Aviv University, Israel., Goldschmidt E; Department of Pathology, Sackler School of Medicine, Tel Aviv University, Israel., Boddapati AK; NIAID Collaborative Bioinformatics Resource, National Institutes of Health, Bethesda, MD, USA., Sohn H; Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, USA., Sturdevant D; RML Genomics Unit, Research Technologies Section, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA., Austin JW; Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Kardava L; Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Yuesheng L; National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA., Liu P; National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA., Moir S; Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Pierce SK; Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, USA. asafmadi@gmail.com spierce@nih.gov., Madi A; Department of Pathology, Sackler School of Medicine, Tel Aviv University, Israel. asafmadi@gmail.com spierce@nih.gov.

Publikováno v: Science advances [Sci Adv] 2021 May 26; Vol. 7 (22). Date of Electronic Publication: 2021 May 26 (Print Publication: 2021).

Expression of inhibitory receptors by B cells in chronic human infectious diseases restricts responses to membrane-associated antigens.

Autor: Ambegaonkar AA; Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, USA., Kwak K; Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, USA., Sohn H; Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, USA., Manzella-Lapeira J; Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, USA., Brzostowski J; Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, USA., Pierce SK; Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, USA.

Publikováno v: Science advances [Sci Adv] 2020 Jul 24; Vol. 6 (30), pp. eaba6493. Date of Electronic Publication: 2020 Jul 24 (Print Publication: 2020).

Coordination of planar cell polarity pathways through Spiny-legs.

Autor: Ambegaonkar AA; Howard Hughes Medical Institute, Rutgers University, Piscataway, United States.; Waksman Institute of Microbiology, Rutgers University, Piscataway, United States.; Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, United States., Irvine KD; Howard Hughes Medical Institute, Rutgers University, Piscataway, United States.; Waksman Institute of Microbiology, Rutgers University, Piscataway, United States.; Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, United States.

Publikováno v: ELife [Elife] 2015 Oct 27; Vol. 4. Date of Electronic Publication: 2015 Oct 27.

Propagation of Dachsous-Fat planar cell polarity.

Autor: Ambegaonkar AA; Howard Hughes Medical Institute, Waksman Institute and Department of Molecular Biology and Biochemistry, Rutgers-The State University of New Jersey, Piscataway, NJ 08854, USA., Pan G, Mani M, Feng Y, Irvine KD

Publikováno v: Current biology : CB [Curr Biol] 2012 Jul 24; Vol. 22 (14), pp. 1302-8. Date of Electronic Publication: 2012 Jun 21.