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Akademický článek

Probing N-substituted 4-(5-mercapto-4-ethyl-4H-1,2,4-triazol-3-yl)-N-phenylpiperdine-1-carboxamides as potent 15-LOX inhibitors supported with ADME, DFT calculations and molecular docking studies

Autor: Zahid Nawaz, Naheed Riaz, Muhammad Saleem, Ambar Iqbal, Syeda Abida Ejaz, Saima Muzaffar, Bushra Bashir, Muhammad Ashraf, Aziz-ur Rehman, Muhammad Sajjad Bilal, Bala Krishna Prabhala, Salvia Sajid

Publikováno v: Heliyon, Vol 10, Iss 17, Pp e35278- (2024)

In our continuous efforts to find out leads against the enzyme 15-lipoxygenase (15-LOX), the current study deals with the synthesis of a series of new N-alkyl/aralkyl/aryl derivatives of 2-(4-ethyl-5-(1-phenylcarbamoyl)piperidine-4H-1,2,4-triazol-3-y

Externí odkaz: https://doaj.org/article/c44960fd243e4e7cba2b3eea87bef43f

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Akademický článek

Anti-enzymatic and DNA docking studies of montelukast: A multifaceted molecular scaffold with in vitro investigations, molecular expression analysis and molecular dynamics simulations

Autor: Shawana Abdullah, Ambar Iqbal, Avinash Karkada Ashok, Farah Chafika Kaouche, Misbah Aslam, Safdar Hussain, Jameel Rahman, Muhammad Munawar Hayat, Muhammad Ashraf

Publikováno v: Heliyon, Vol 10, Iss 2, Pp e24470- (2024)

Montelukast, an approved leukotriene receptor 1 (Cys-LT 1) antagonist with anti-inflammatory properties is used for the treatment of asthma and allergic rhinitis. In the present studies, montelukast was subjected to in vitro inhibitory assays followe

Externí odkaz: https://doaj.org/article/af74bf65a41d44ea9ab0c5e9e4924f2c

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Akademický článek

Biological activity of synthesized 5-{1-[(4-chlorophenyl)sulfonyl]piperidin-4-yl}-2-mercapto-1,3,4-oxadiazole derivatives demonstrated by in silico and BSA binding studies

Autor: Javed Iqbal, Aziz-ur- Rehman, Muhammad Athar Abbasi, Sabahat Zahra Siddiqui, Shahid Rasool, Muhammad Ashraf, Ambar Iqbal, Sujhla Hamid, Tahir Ali Chohan, Hira Khalid, Sabina Jhaumeer Laulloo, Syed Adnan Ali Shah

Publikováno v: Brazilian Journal of Pharmaceutical Sciences, Vol 56 (2020)

We synthesized a series of compounds bearing pharmacologically important 1,3,4-oxadiazole and piperidine moieties. Spectral data analysis by 1H-NMR, 13C-NMR, IR and EI-MS was used to elucidate the structures of the synthesized molecules. Docking stud

Externí odkaz: https://doaj.org/article/1cfa670315a84bd18614836253adea14

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Investigations of p-tolyloxy-1,3,4-oxadiazole propionamides as soybean 15-lipoxygenase inhibitors in comforting with in vitro and in silico studies

Autor: Bushra Bashir, Naheed Riaz, Syeda Abida Ejaz, Muhammad Saleem, Ambar Iqbal, Muhammad Ashraf, Samina Ejaz, Aziz-ur -Rehman, Mubashir Aziz, Keshab Bhattarai

Inflammatory disorders are the prime contributor to public health issue and the development of more effective and safer anti-inflammatory drugs in addition to other therapeutic alternatives to treat inflammatory illnesses, particularly chronic inflam

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7444f65897bc0534b34236cb1036de8

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Assessing p-tolyloxy-1,3,4-oxadiazole acetamides as lipoxygenase inhibitors assisted by in vitro and in silico studies

Autor: Bushra, Bashir, Naheed, Riaz, Syeda, Abida Ejaz, Muhammad, Saleem, Muhammad, Ashraf, Ambar, Iqbal, Saima, Muzaffar, Samina, Ejaz, Aziz-Ur-Rehman, Hafiz, Mohammad Kashif Mahmood, Keshab, Bhattarai

Publikováno v: Bioorganic Chemistry. 129:106144

The underlying correlation between the inflammation, innate immunity and cancer is extensively familiar and linked through a process mediated by three enzymes; cyclooxygenase (COX), lipoxygenase (LOX) and cytochrome P450 (CYPsub450/sub). The ever inc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc004226fef79102244de8bd183aa6bf
https://doi.org/10.1016/j.bioorg.2022.106144

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Synthesis, Characterization, Molecular Docking and Enzyme Inhibition Studies of Some Novel Enaminone Derivatives and Their Complexes with Cu(II), Cd(II) and Co(II) Ions

Autor: Tariq Mahmud, Kiran Iftikhar, Ambar Iqbal, Anum Hayat, Rahila Huma, Liviu Mitu, Muhammad Ashraf

Publikováno v: Revista de Chimie. 70:3564-3569

Two new enaminone ligands, 3-chloro-4-{(4-chlorophenyl)amino}pent-3-en-2-one (Ac-PCA), 4-(benzylamino)-3-chloropent-3-en-2-one (Ac-BA) and their metal complexes with transition metal ions [Cu(II), Cd(II) and Co(II)] were prepared and subsequently cha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::be911d7dac57288a4e44024c3c3db99e
https://doi.org/10.37358/rc.19.10.7597

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Biological activity of synthesized 5-{1-[(4-chlorophenyl)sulfonyl]piperidin-4- yl}-2-mercapto-1,3,4-oxadiazole derivatives demonstrated by in silico and BSA binding studies

Autor: Tahir Ali Chohan, Syed Adnan Ali Shah, Muhammad Athar Abbasi, Aziz-ur Rehman, Sabina Jhaumeer Laulloo, Hira Khalid, Javed Iqbal, Shahid Rasool, Sujhla Hamid, Ambar Iqbal, Sabahat Zahra Siddiqui, Muhammad Ashraf

Publikováno v: Brazilian Journal of Pharmaceutical Sciences; Vol. 56 (2020); e18092
Brazilian Journal of Pharmaceutical Sciences; v. 56 (2020); e18092
Brazilian Journal of Pharmaceutical Sciences
Universidade de São Paulo (USP)
instacron:USP
Brazilian Journal of Pharmaceutical Sciences, Volume: 56, Article number: e18092, Published: 07 DEC 2020
Brazilian Journal of Pharmaceutical Sciences, Vol 56 (2020)

We synthesized a series of compounds bearing pharmacologically important 1,3,4-oxadiazole and piperidine moieties. Spectral data analysis by 1 H-NMR, 13C-NMR, IR and EI-MS was used to elucidate the structures of the synthesized molecules. Docking stu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b194e5f9296397eb6aeec8fe975241f6
https://www.revistas.usp.br/bjps/article/view/182524

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