Anti-seizure effects of JNJ-54175446 in the intra-amygdala kainic acid model of drug-resistant temporal lobe epilepsy in mice

Autor: Omar Mamad, Mona Heiland, Andreas U. Lindner, Thomas D. M. Hill, Ronan M. Ronroy, Kilian Rentrup, Amaya Sanz-Rodriguez, Elena Langa, Janosch P. Heller, Oscar Moreno, Jordi Llop, Anindya Bhattacharya, James A. Palmer, Marc Ceusters, Tobias Engel, David C. Henshall

Publikováno v: Frontiers in Pharmacology, Vol 14 (2024)

There remains a need for new drug targets for treatment-resistant temporal lobe epilepsy. The ATP-gated P2X7 receptor coordinates neuroinflammatory responses to tissue injury. Previous studies in mice reported that the P2X7 receptor antagonist JNJ-47

Externí odkaz: https://doaj.org/article/4fa05e1ff28e4d35a32f692bc0e2ed81

Genetic deletion of microRNA-22 blunts the inflammatory transcriptional response to status epilepticus and exacerbates epilepsy in mice

Autor: Luiz F. Almeida Silva, Cristina R. Reschke, Ngoc T. Nguyen, Elena Langa, Amaya Sanz-Rodriguez, Rogerio R. Gerbatin, Fernanda R. Temp, Mayara L. de Freitas, Ronan M. Conroy, Gary P. Brennan, Tobias Engel, David C. Henshall

Publikováno v: Molecular Brain, Vol 13, Iss 1, Pp 1-15 (2020)

Abstract MicroRNAs perform important roles in the post-transcriptional regulation of gene expression. Sequencing as well as functional studies using antisense oligonucleotides indicate important roles for microRNAs during the development of epilepsy

Externí odkaz: https://doaj.org/article/437cebdae0ed4f06ac210951c4c7a083

Altered Biogenesis and MicroRNA Content of Hippocampal Exosomes Following Experimental Status Epilepticus

Autor: Aasia Batool, Thomas D. M. Hill, Ngoc T. Nguyen, Elena Langa, Mairéad Diviney, Catherine Mooney, Gary P. Brennan, Niamh M. C. Connolly, Amaya Sanz-Rodriguez, Brenton L. Cavanagh, David C. Henshall

Publikováno v: Frontiers in Neuroscience, Vol 13 (2020)

Repetitive or prolonged seizures (status epilepticus) can damage neurons within the hippocampus, trigger gliosis, and generate an enduring state of hyperexcitability. Recent studies have suggested that microvesicles including exosomes are released fr

Externí odkaz: https://doaj.org/article/46abeaf665154000a4909c438eaf4e3c

High Throughput qPCR Expression Profiling of Circulating MicroRNAs Reveals Minimal Sex- and Sample Timing-Related Variation in Plasma of Healthy Volunteers.

Autor: Catherine Mooney, Rana Raoof, Hany El-Naggar, Amaya Sanz-Rodriguez, Eva M Jimenez-Mateos, David C Henshall

Publikováno v: PLoS ONE, Vol 10, Iss 12, p e0145316 (2015)

MicroRNAs are a class of small non-coding RNA that regulate gene expression at a post-transcriptional level. MicroRNAs have been identified in various body fluids under normal conditions and their stability as well as their dysregulation in disease o

Externí odkaz: https://doaj.org/article/89ef708c8b584479a8aedc1297b884b2

A systems approach delivers a functional microRNA catalog and expanded targets for seizure suppression in temporal lobe epilepsy

Autor: Cristina R. Reschke, Junyi Su, Lara S. Costard, R. Jeroen Pasterkamp, Vamshidhar R. Vangoor, Gary P. Brennan, Federico Del Gallo, Tobias Engel, Valentin Neubert, Jochen H. M. Prehn, Aoife Campbell, Dennis Pultz, Lea M. Harder, Janosch P. Heller, Morten T. Venø, Yan Yan, David C. Henshall, Braxton A. Norwood, Jørgen Kjems, Niamh M. C. Connolly, Gareth Morris, Jens S. Andersen, Amaya Sanz-Rodriguez, Elena Langa, Stephanie Schorge, Felix Rosenow, Ajay Pal, Beatrice Salvetti, Karen Conboy, Juha Muilu, Paolo F. Fabene, Sebastian Bauer, Eva M. Jimenez-Mateos, Stefan J. Haunsberger, Amy Richardson

Publikováno v: Venø, M T, Reschke, C R, Morris, G, Connolly, N M C, Su, J, Yan, Y, Engel, T, Jimenez-Mateos, E M, Harder, L M, Pultz, D, Haunsberger, S J, Pal, A, Heller, J P, Campbell, A, Langa, E, Brennan, G P, Conboy, K, Richardson, A, Norwood, B A, Costard, L S, Neubert, V, Gallo, F D, Salvetti, B, Vangoor, V R, Sanz-Rodriguez, A, Muilu, J, Fabene, P F, Pasterkamp, R J, Prehn, J H M, Schorge, S, Andersen, J S, Rosenow, F, Bauer, S, Kjems, J & Henshall, D C 2020, ' A systems approach delivers a functional microRNA catalog and expanded targets for seizure suppression in temporal lobe epilepsy ', Proceedings of the National Academy of Sciences of the United States of America, vol. 117, no. 27, pp. 15977-15988 . https://doi.org/10.1073/pnas.1919313117
Proceedings of the National Academy of Sciences
Venø, M T, Reschke, C R, Morris, G, Connolly, N M C, Su, J, Yan, Y, Engel, T, Jimenez-Mateos, E M, Harder, L M, Pultz, D, Haunsberger, S J, Pal, A, Heller, J P, Campbell, A, Langa, E, Brennan, G P, Conboy, K, Richardson, A, Norwood, B A, Costard, L S, Neubert, V, Del Gallo, F, Salvetti, B, Vangoor, V R, Sanz-Rodriguez, A, Muilu, J, Fabene, P F, Pasterkamp, R J, Prehn, J H M, Schorge, S, Andersen, J S, Rosenow, F, Bauer, S, Kjems, J & Henshall, D C 2020, ' A systems approach delivers a functional microRNA catalog and expanded targets for seizure suppression in temporal lobe epilepsy ', Proceedings of the National Academy of Sciences of the United States of America, vol. 117, no. 27, 27, pp. 15977-15988 . https://doi.org/10.1073/pnas.1919313117
Proceedings of the National Academy of Sciences of the United States of America

Significance Temporal lobe epilepsy is commonly drug resistant and is associated with dysregulated hippocampal gene expression. MicroRNAs are short noncoding RNAs which control protein levels by binding target mRNAs via Argonaute proteins. We sequenc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ef11a947b31811a4b5bce9f9ba6f9dd
https://pure.au.dk/ws/files/224579357/15977.full.pdf