Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Amaya Garcia Munoz"'
Autor:
Sean P. Kennedy, Jeremy Z. R. Han, Neil Portman, Max Nobis, Jordan F. Hastings, Kendelle J. Murphy, Sharissa L. Latham, Antonia L. Cadell, Dushan Miladinovic, Gabriella R. Marriott, Yolande E. I. O’Donnell, Robert F. Shearer, James T. Williams, Amaya Garcia Munoz, Thomas R. Cox, D. Neil Watkins, Darren N. Saunders, Paul Timpson, Elgene Lim, Walter Kolch, David R. Croucher
Publikováno v:
Breast Cancer Research, Vol 21, Iss 1, Pp 1-17 (2019)
Abstract Background The oncogenic receptor tyrosine kinase (RTK) ERBB2 is known to dimerize with other EGFR family members, particularly ERBB3, through which it potently activates PI3K signalling. Antibody-mediated inhibition of this ERBB2/ERBB3/PI3K
Externí odkaz:
https://doaj.org/article/63c93a219e074dd1a11996f46df83abd
Autor:
Javier Rodriguez, Ruth Pilkington, Amaya Garcia Munoz, Lan K. Nguyen, Nora Rauch, Susan Kennedy, Naser Monsefi, Ana Herrero, Cormac T. Taylor, Alex von Kriegsheim
Publikováno v:
Cell Reports, Vol 14, Iss 11, Pp 2745-2760 (2016)
Amino acid hydroxylation is a post-translational modification that regulates intra- and inter-molecular protein-protein interactions. The modifications are regulated by a family of 2-oxoglutarate- (2OG) dependent enzymes and, although the biochemistr
Externí odkaz:
https://doaj.org/article/00ee3bfef4a149938e0c86349229f870
Autor:
Christine P Diggle, Daniel J Moore, Girish Mali, Petra zur Lage, Aouatef Ait-Lounis, Miriam Schmidts, Amelia Shoemark, Amaya Garcia Munoz, Mihail R Halachev, Philippe Gautier, Patricia L Yeyati, David T Bonthron, Ian M Carr, Bruce Hayward, Alexander F Markham, Jilly E Hope, Alex von Kriegsheim, Hannah M Mitchison, Ian J Jackson, Bénédicte Durand, Walter Reith, Eamonn Sheridan, Andrew P Jarman, Pleasantine Mill
Publikováno v:
PLoS Genetics, Vol 10, Iss 9, p e1004577 (2014)
Cilia are highly conserved microtubule-based structures that perform a variety of sensory and motility functions during development and adult homeostasis. In humans, defects specifically affecting motile cilia lead to chronic airway infections, infer
Externí odkaz:
https://doaj.org/article/221a47d3cc01479e8e83de40453586ea
Publikováno v:
PLoS Computational Biology, Vol 10, Iss 7, p e1003763 (2014)
Biological systems are known to be both robust and evolvable to internal and external perturbations, but what causes these apparently contradictory properties? We used Boolean network modeling and attractor landscape analysis to investigate the evolv
Externí odkaz:
https://doaj.org/article/8a34694fec9d480d8697237c208bd359
Autor:
Alfonso Bolado-Carrancio, Oleksii S Rukhlenko, Elena Nikonova, Mikhail A Tsyganov, Anne Wheeler, Amaya Garcia-Munoz, Walter Kolch, Alex von Kriegsheim, Boris N Kholodenko
Publikováno v:
eLife, Vol 9 (2020)
Migrating cells need to coordinate distinct leading and trailing edge dynamics but the underlying mechanisms are unclear. Here, we combine experiments and mathematical modeling to elaborate the minimal autonomous biochemical machinery necessary and s
Externí odkaz:
https://doaj.org/article/e234ace27d2849c19bad48f7f823ec30
Autor:
Girish R Mali, Patricia L Yeyati, Seiya Mizuno, Daniel O Dodd, Peter A Tennant, Margaret A Keighren, Petra zur Lage, Amelia Shoemark, Amaya Garcia-Munoz, Atsuko Shimada, Hiroyuki Takeda, Frank Edlich, Satoru Takahashi, Alex von Kreigsheim, Andrew P Jarman, Pleasantine Mill
Publikováno v:
eLife, Vol 7 (2018)
Molecular chaperones promote the folding and macromolecular assembly of a diverse set of ‘client’ proteins. How ubiquitous chaperone machineries direct their activities towards specific sets of substrates is unclear. Through the use of mouse gene
Externí odkaz:
https://doaj.org/article/27117010a0254df1a32e0270b4de8c8e
Autor:
Christina Schoenherr, Adam Byron, Emma Sandilands, Ketevan Paliashvili, George S Baillie, Amaya Garcia-Munoz, Cristina Valacca, Francesco Cecconi, Bryan Serrels, Margaret C Frame
Publikováno v:
eLife, Vol 6 (2017)
Here, using mouse squamous cell carcinoma cells, we report a completely new function for the autophagy protein Ambra1 as the first described ‘spatial rheostat’ controlling the Src/FAK pathway. Ambra1 regulates the targeting of active phospho-Src
Externí odkaz:
https://doaj.org/article/7aa48c44f5304c8d82115c88d5b94df4
Autor:
Elena Nikonova, Amaya Garcia-Munoz, Alfonso Bolado-Carrancio, Alex von Kriegsheim, Walter Kolch, Anne Wheeler, Mikhail A Tsyganov, Boris N. Kholodenko, Oleksii S. Rukhlenko
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::58913612a4a2a31ed42667be8a7e5a47
https://doi.org/10.7554/elife.58165.sa2
https://doi.org/10.7554/elife.58165.sa2
Autor:
Anne Wheeler, Alfonso Bolado-Carrancio, Boris N. Kholodenko, Oleksii S. Rukhlenko, Amaya Garcia-Munoz, Walter Kolch, Mikhail A Tsyganov, Elena Nikonova, Alex von Kriegsheim
Publikováno v:
eLife Science
Bolado Carrancio, A, Rukhlenko, O, Nikonova, E, Tsyganov, MA, Wheeler, A P, Garcia Munoz, A, Kolch, W, von Kriegsheim, A & Kholodenko, B N 2020, ' Periodic propagating waves coordinate RhoGTPase network dynamics at the leading and trailing edges during cell migration ', eLIFE, vol. 9, 58165 . https://doi.org/10.7554/eLife.58165
eLife
eLife, Vol 9 (2020)
Bolado Carrancio, A, Rukhlenko, O, Nikonova, E, Tsyganov, MA, Wheeler, A P, Garcia Munoz, A, Kolch, W, von Kriegsheim, A & Kholodenko, B N 2020, ' Periodic propagating waves coordinate RhoGTPase network dynamics at the leading and trailing edges during cell migration ', eLIFE, vol. 9, 58165 . https://doi.org/10.7554/eLife.58165
eLife
eLife, Vol 9 (2020)
Migrating cells need to coordinate distinct leading and trailing edge dynamics but the underlying mechanisms are unclear. Here, we combine experiments and mathematical modeling to elaborate the minimal autonomous biochemical machinery necessary and s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b160d7b97f9fe459f014c409e1fe9c0
https://doi.org/10.1101/2020.03.09.984054
https://doi.org/10.1101/2020.03.09.984054
Autor:
Daniel Lietha, Alex von Kriegsheim, Morwenna Muir, Neil O. Carragher, John C. Dawson, Amaya Garcia-Munoz, Ashraff Makda, Margaret C. Frame, Bryan Serrels, Adam Byron
Publikováno v:
Dawson, J C, Serrels, B, Byron, A, Muir, M T, Makda, A, García-Muñoz, A, von Kriegsheim, A, Lietha, D, Carragher, N O & Frame, M C 2020, ' A synergistic anticancer FAK and HDAC inhibitor combination discovered by a novel chemical–genetic high-content phenotypic screen ', Molecular Cancer Therapeutics, vol. 19, no. 2, pp. 637-649 . https://doi.org/10.1158/1535-7163.MCT-19-0330
Dawson, J C, Serrels, B, Byron, A, Muir, M, Makda, A, Garcia-Muñoz, A, von Kriegsheim, A, Lietha, D, Carragher, N O & Frame, M 2020, ' A synergistic anti-cancer FAK and HDAC inhibitor combination discovered by a novel chemical-genetic high-content phenotypic screen ', Molecular Cancer Therapeutics, vol. 19, no. 2, pp. 637–649 . https://doi.org/10.1158/1535-7163.MCT-19-0330
Mol Cancer Ther
Dawson, J C, Serrels, B, Byron, A, Muir, M, Makda, A, Garcia-Muñoz, A, von Kriegsheim, A, Lietha, D, Carragher, N O & Frame, M 2020, ' A synergistic anti-cancer FAK and HDAC inhibitor combination discovered by a novel chemical-genetic high-content phenotypic screen ', Molecular Cancer Therapeutics, vol. 19, no. 2, pp. 637–649 . https://doi.org/10.1158/1535-7163.MCT-19-0330
Mol Cancer Ther
We mutated the Focal Adhesion Kinase (FAK) catalytic domain to inhibit binding of the chaperone, Cdc37 and ATP, mimicking the actions of a FAK kinase inhibitor. We re-expressed mutant and wild-type FAK in squamous cell carcinoma (SCC) cells from whic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1ef517b6ed1e5aeb45a511d38d70f6e
https://doi.org/10.1158/1535-7163.MCT-19-0330
https://doi.org/10.1158/1535-7163.MCT-19-0330