Zobrazeno 1 - 10
of 91
pro vyhledávání: '"Amaury Farce"'
Autor:
Karen Aknin, Alexis Bontemps, Amaury Farce, Eric Merlet, Philippe Belmont, Philippe Helissey, Philippe Chavatte, Marie-Agnès Sari, Sylviane Giorgi-Renault, Stéphanie Desbène-Finck
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 37, Iss 1, Pp 252-268 (2022)
New polycyclic heterocycles were synthesised and evaluated as potential inhibitors of thymidine phosphorylase (TP). Inspired by the pharmacophoric pyrimidinedione core of the natural substrate, four series have been designed in order to interact with
Externí odkaz:
https://doaj.org/article/1c7dc5e7c7d94f0b8e312f4d2f4c2263
Autor:
Marie Bobowski-Gerard, Clémence Boulet, Francesco P. Zummo, Julie Dubois-Chevalier, Céline Gheeraert, Mohamed Bou Saleh, Jean-Marc Strub, Amaury Farce, Maheul Ploton, Loïc Guille, Jimmy Vandel, Antonino Bongiovanni, Ninon Very, Eloïse Woitrain, Audrey Deprince, Fanny Lalloyer, Eric Bauge, Lise Ferri, Line-Carolle Ntandja-Wandji, Alexia K. Cotte, Corinne Grangette, Emmanuelle Vallez, Sarah Cianférani, Violeta Raverdy, Robert Caiazzo, Viviane Gnemmi, Emmanuelle Leteurtre, Benoit Pourcet, Réjane Paumelle, Kim Ravnskjaer, Guillaume Lassailly, Joel T. Haas, Philippe Mathurin, François Pattou, Laurent Dubuquoy, Bart Staels, Philippe Lefebvre, Jérôme Eeckhoute
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-20 (2022)
Myofibroblasts contribute to the development of liver fibrosis. Here, the authors report that the transcription factor Basonuclin 2 (BNC2) integrates fibrogenic signals and drives myofibroblastic transcriptional activation in liver fibrosis.
Externí odkaz:
https://doaj.org/article/c0d2d56ec91641b79809fad780054395
Autor:
Hala Mansour, Alejandro Cabezas-Cruz, Véronique Peucelle, Amaury Farce, Sophie Salomé-Desnoulez, Ines Metatla, Ida Chiara Guerrera, Thomas Hollin, Jamal Khalife
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 16, p 12647 (2023)
The Protein Phosphatase type 1 catalytic subunit (PP1c) (PF3D7_1414400) operates in combination with various regulatory proteins to specifically direct and control its phosphatase activity. However, there is little information about this phosphatase
Externí odkaz:
https://doaj.org/article/f2cb222fbdee41989b2f496902abc253
Publikováno v:
Pharmaceuticals, Vol 16, Iss 6, p 888 (2023)
In the search for innovative approaches to cancer chemotherapy, a chemical library of 49 cyanochalcones, 1a-r, 2a-o, and 3a-p, was designed as dual inhibitors of human farnesyltransferase (FTIs) and tubulin polymerization (MTIs) (FTIs/MTIs), two impo
Externí odkaz:
https://doaj.org/article/7a614bbe9e6449458fb251afebe52d6c
Autor:
Nicolas Sergeant, Valérie Vingtdeux, Sabiha Eddarkaoui, Marion Gay, Caroline Evrard, Nicolas Le Fur, Cyril Laurent, Raphaelle Caillierez, Hélène Obriot, Paul-Emmanuel Larchanché, Amaury Farce, Mathilde Coevoet, Pascal Carato, Mostafa Kouach, Amandine Descat, Patrick Dallemagne, Valérie Buée-Scherrer, David Blum, Malika Hamdane, Luc Buée, Patricia Melnyk
Publikováno v:
Neurobiology of Disease, Vol 129, Iss , Pp 217-233 (2019)
Alzheimer's Disease is a devastating dementing disease involving amyloid deposits, neurofibrillary tangles, progressive and irreversible cognitive impairment. Today, only symptomatic drugs are available and therapeutic treatments, possibly acting at
Externí odkaz:
https://doaj.org/article/81981f930cdb439bb251f4f9165c75b8
Autor:
Nicolas Kambia, Isabelle Séverin, Amaury Farce, Laurence Dahbi, Thierry Dine, Emmanuel Moreau, Valérie Sautou, Marie-Christine Chagnon
Publikováno v:
Metabolites, Vol 11, Iss 2, p 94 (2021)
Plasticizers added to polyvinylchloride (PVC) used in medical devices can be released into patients’ biological fluids. Di-(2-ethylhexyl)phthalate (DEHP), a well-known reprotoxic and endocrine disruptor, must be replaced by alternative compounds. D
Externí odkaz:
https://doaj.org/article/6f527d83eb79492db1a2e83c1fd0bd5a
Autor:
Floriane Gibault, Mathilde Coevoet, Manon Sturbaut, Amaury Farce, Nicolas Renault, Frédéric Allemand, Jean-François Guichou, Anne-Sophie Drucbert, Catherine Foulon, Romain Magnez, Xavier Thuru, Matthieu Corvaisier, Guillemette Huet, Philippe Chavatte, Patricia Melnyk, Fabrice Bailly, Philippe Cotelle
Publikováno v:
Cancers, Vol 10, Iss 5, p 140 (2018)
Intrinsically disordered protein YAP (yes-associated protein) interacts with TEADs transcriptional factors family (transcriptional enhancer associated domain) creating three interfaces. Interface 3, between the Ω-loop of YAP and a shallow pocket of
Externí odkaz:
https://doaj.org/article/577e777214884ea1a55d9d4629a58796
Publikováno v:
PLoS Computational Biology, Vol 10, Iss 11, p e1003902 (2014)
A number of potentially bioactive molecules can be found in nature. In particular, marine organisms are a valuable source of bioactive compounds. The activity of an α-galactosylceramide was first discovered in 1993 via screening of a Japanese marine
Externí odkaz:
https://doaj.org/article/a2e28f9da87d4bb39de8f6b6c4e5993a
Publikováno v:
Pharmaceuticals; Volume 16; Issue 6; Pages: 888
In the search for innovative approaches to cancer chemotherapy, a chemical library of 49 cyanochalcones, 1a-r, 2a-o, and 3a-p, was designed as dual inhibitors of human farnesyltransferase (FTIs) and tubulin polymerization (MTIs) (FTIs/MTIs), two impo
Autor:
Corentin Bedart, Nicolas Renault, Philippe Chavatte, Adeline Porcherie, Abderrahim Lachgar, Monique Capron, Amaury Farce
Publikováno v:
Journal of Chemical Information and Modeling
Journal of Chemical Information and Modeling, 2022, 62 (6), pp.1425-1436. ⟨10.1021/acs.jcim.1c00854⟩
Journal of Chemical Information and Modeling, 2022, 62 (6), pp.1425-1436. ⟨10.1021/acs.jcim.1c00854⟩
International audience; As long as the structural study of molecular mechanisms requires multiple molecular dynamics reflecting contrasted bioactive states, the subsequent analysis of molecular interaction networks remains a bottleneck to be fairly t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::771a031e7a610ecb7d46de98f0d8e86f
https://hal.univ-lille.fr/hal-04077236/document
https://hal.univ-lille.fr/hal-04077236/document