Functional genomics uncovers the transcription factor BNC2 as required for myofibroblastic activation in fibrosis

Autor: Marie Bobowski-Gerard, Clémence Boulet, Francesco P. Zummo, Julie Dubois-Chevalier, Céline Gheeraert, Mohamed Bou Saleh, Jean-Marc Strub, Amaury Farce, Maheul Ploton, Loïc Guille, Jimmy Vandel, Antonino Bongiovanni, Ninon Very, Eloïse Woitrain, Audrey Deprince, Fanny Lalloyer, Eric Bauge, Lise Ferri, Line-Carolle Ntandja-Wandji, Alexia K. Cotte, Corinne Grangette, Emmanuelle Vallez, Sarah Cianférani, Violeta Raverdy, Robert Caiazzo, Viviane Gnemmi, Emmanuelle Leteurtre, Benoit Pourcet, Réjane Paumelle, Kim Ravnskjaer, Guillaume Lassailly, Joel T. Haas, Philippe Mathurin, François Pattou, Laurent Dubuquoy, Bart Staels, Philippe Lefebvre, Jérôme Eeckhoute

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-20 (2022)

Myofibroblasts contribute to the development of liver fibrosis. Here, the authors report that the transcription factor Basonuclin 2 (BNC2) integrates fibrogenic signals and drives myofibroblastic transcriptional activation in liver fibrosis.

Externí odkaz: https://doaj.org/article/c0d2d56ec91641b79809fad780054395

New piperazine multi-effect drugs prevent neurofibrillary degeneration and amyloid deposition, and preserve memory in animal models of Alzheimer's disease

Autor: Nicolas Sergeant, Valérie Vingtdeux, Sabiha Eddarkaoui, Marion Gay, Caroline Evrard, Nicolas Le Fur, Cyril Laurent, Raphaelle Caillierez, Hélène Obriot, Paul-Emmanuel Larchanché, Amaury Farce, Mathilde Coevoet, Pascal Carato, Mostafa Kouach, Amandine Descat, Patrick Dallemagne, Valérie Buée-Scherrer, David Blum, Malika Hamdane, Luc Buée, Patricia Melnyk

Publikováno v: Neurobiology of Disease, Vol 129, Iss , Pp 217-233 (2019)

Alzheimer's Disease is a devastating dementing disease involving amyloid deposits, neurofibrillary tangles, progressive and irreversible cognitive impairment. Today, only symptomatic drugs are available and therapeutic treatments, possibly acting at

Externí odkaz: https://doaj.org/article/81981f930cdb439bb251f4f9165c75b8

Relationships between Th1 or Th2 iNKT cell activity and structures of CD1d-antigen complexes: meta-analysis of CD1d-glycolipids dynamics simulations.

Autor: Xavier Laurent, Nicolas Renault, Amaury Farce, Philippe Chavatte, Eric Hénon

Publikováno v: PLoS Computational Biology, Vol 10, Iss 11, p e1003902 (2014)

A number of potentially bioactive molecules can be found in nature. In particular, marine organisms are a valuable source of bioactive compounds. The activity of an α-galactosylceramide was first discovered in 1993 via screening of a Japanese marine

Externí odkaz: https://doaj.org/article/a2e28f9da87d4bb39de8f6b6c4e5993a

SINAPs: A Software Tool for Analysis and Visualization of Interaction Networks of Molecular Dynamics Simulations

Autor: Corentin Bedart, Nicolas Renault, Philippe Chavatte, Adeline Porcherie, Abderrahim Lachgar, Monique Capron, Amaury Farce

Publikováno v: Journal of Chemical Information and Modeling
Journal of Chemical Information and Modeling, 2022, 62 (6), pp.1425-1436. ⟨10.1021/acs.jcim.1c00854⟩

International audience; As long as the structural study of molecular mechanisms requires multiple molecular dynamics reflecting contrasted bioactive states, the subsequent analysis of molecular interaction networks remains a bottleneck to be fairly t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::771a031e7a610ecb7d46de98f0d8e86f
https://hal.univ-lille.fr/hal-04077236/document

Comparative Effects of Di-(2-ethylhexyl)phthalate and Di-(2-ethylhexyl)terephthalate Metabolites on Thyroid Receptors: In Vitro and In Silico Studies

Autor: Valérie Sautou, Marie-Christine Chagnon, Laurence Dahbi, Nicolas Kambia, Isabelle Severin, Emmanuel Moreau, Amaury Farce, Thierry Dine

Publikováno v: Metabolites
Metabolites, 2021, 11 (2), pp.94. ⟨10.3390/metabo11020094⟩
Metabolites, Vol 11, Iss 94, p 94 (2021)
Volume 11
Issue 2
Metabolites, MDPI, 2021, 11 (2), pp.94. ⟨10.3390/metabo11020094⟩

International audience; Plasticizers added to polyvinylchloride (PVC) used in medical devices can be released into patients’ biological fluids. Di-(2-ethylhexyl)phthalate (DEHP), a well-known reprotoxic and endocrine disruptor, must be replaced by

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19dc250952426e4467599cc992e4bea7
https://hal.science/hal-03141182/document