Zobrazeno 1 - 10
of 519
pro vyhledávání: '"Amato J. Giaccia"'
Autor:
Katarzyna B. Leszczynska, Monika Dzwigonska, Hala Estephan, Jutta Moehlenbrink, Elizabeth Bowler, Amato J. Giaccia, Jakub Mieczkowski, Bozena Kaminska, Ester M. Hammond
Publikováno v:
Molecular Oncology, Vol 17, Iss 7, Pp 1173-1191 (2023)
Local hypoxia occurs in most solid tumors and is associated with aggressive disease and therapy resistance. Widespread changes in gene expression play a critical role in the biological response to hypoxia. However, most research has focused on hypoxi
Externí odkaz:
https://doaj.org/article/322ae7bae5474bcc992e7a2cd94f8ce2
Autor:
Timothy D. Klasson, Edward L. LaGory, Hongjuan Zhao, Star K. Huynh, Ioanna Papandreou, Eui Jung Moon, Amato J. Giaccia
Publikováno v:
Cancer & Metabolism, Vol 10, Iss 1, Pp 1-17 (2022)
Abstract Background Clear cell renal cell carcinoma (ccRCC), the predominant subtype of kidney cancer, possesses characteristic alterations to multiple metabolic pathways, including the accumulation of cytosolic lipid droplets. However, the pathways
Externí odkaz:
https://doaj.org/article/31c54fc7899d4d009ae61cd9a6805ec7
Autor:
Eui Jung Moon, Stephano S. Mello, Caiyun G. Li, Jen-Tsan Chi, Kaushik Thakkar, Jacob G. Kirkland, Edward L. Lagory, Ik Jae Lee, Anh N. Diep, Yu Miao, Marjan Rafat, Marta Vilalta, Laura Castellini, Adam J. Krieg, Edward E. Graves, Laura D. Attardi, Amato J. Giaccia
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Hypoxia plays a critical role in tumor progression including invasion and metastasis. Here, the authors screened several hypoxia inducible genes and identified the oncogenic role of MAFF in breast cancer metastasis and that it activates IL11/STAT3 pa
Externí odkaz:
https://doaj.org/article/74a0bdf041f848a69bf653962a2ec1b4
Autor:
Chun-Lung Chiu, Caiyun G. Li, Erik Verschueren, Ru M. Wen, Dalin Zhang, Catherine A. Gordon, Hongjuan Zhao, Amato J. Giaccia, James D. Brooks
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 7, p 6258 (2023)
Increased expression of NUSAP1 has been identified as a robust prognostic biomarker in prostate cancer and other malignancies. We have previously shown that NUSAP1 is positively regulated by E2F1 and promotes cancer invasion and metastasis. To furthe
Externí odkaz:
https://doaj.org/article/8b7f9b45b212493299a7a5dfc6081550
Publikováno v:
Cancer Reports, Vol 4, Iss 5, Pp n/a-n/a (2021)
Abstract Background Tumor hypoxia is a characteristic of paramount importance due to low oxygenation levels in tissue negatively correlating with resistance to traditional therapies. The ability to noninvasively identify such could provide for person
Externí odkaz:
https://doaj.org/article/9f53f9e6deb246ebbd80460d2a07fb74
Autor:
Xingqi Chen, Ulrike M. Litzenburger, Yuning Wei, Alicia N. Schep, Edward L. LaGory, Hani Choudhry, Amato J. Giaccia, William J. Greenleaf, Howard Y. Chang
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
Cellular heterogeneity in cancer is complex and difficult to study. Here, the authors introduce Protein-indexed Assay of Transposase Accessible Chromatin (Pi-ATAC), which combines single cell chromatin and proteomic profiling to provide deep insight
Externí odkaz:
https://doaj.org/article/78bb993491fb4b9faed443f446fb2949
Autor:
Monica M. Olcina, Ryan K. Kim, Nikolas G. Balanis, Caiyun Grace Li, Rie von Eyben, Thomas G. Graeber, Daniel Ricklin, Manuel Stucki, Amato J. Giaccia
Publikováno v:
iScience, Vol 23, Iss 10, Pp 101594- (2020)
Summary: The importance of innate immunity in cancer is increasingly being recognized with recent reports suggesting tumor cell-intrinsic intracellular functions for innate immunity proteins. However, such functions are often poorly understood, and i
Externí odkaz:
https://doaj.org/article/64c2b7db01984770a3fda8aeaa8c2c2f
Autor:
Todd A. Aguilera, Marjan Rafat, Laura Castellini, Hussein Shehade, Mihalis S. Kariolis, Angela Bik-Yu Hui, Henning Stehr, Rie von Eyben, Dadi Jiang, Lesley G. Ellies, Albert C. Koong, Maximilian Diehn, Erinn B. Rankin, Edward E. Graves, Amato J. Giaccia
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
Radiotherapy can enhance the antitumour immune response. Here, the authors show that resistance to radiation in breast cancer cells can be due to Axl expression that suppresses antigen presentation though MHCI, promotes NF-κB signalling, and enhance
Externí odkaz:
https://doaj.org/article/d32eb98fd69f4bdf897a2cd00a59903c
Autor:
Monica M. Olcina, Nikolas G. Balanis, Ryan K. Kim, B. Arman Aksoy, Julia Kodysh, Michael J. Thompson, Jeff Hammerbacher, Thomas G. Graeber, Amato J. Giaccia
Publikováno v:
Cell Reports, Vol 25, Iss 13, Pp 3721-3732.e6 (2018)
Summary: Complement-mediated cytotoxicity may act as a selective pressure for tumor overexpression of complement regulators. We hypothesize that the same selective pressure could lead to complement alterations at the genetic level. We find that, when
Externí odkaz:
https://doaj.org/article/43f706b039384f6aa667af346e276ebc
Publikováno v:
Sensors, Vol 20, Iss 15, p 4299 (2020)
There has been strong demand for the development of an accurate but simple method to assess the freshness of food. In this study, we demonstrated a system to determine food freshness by analyzing the spectral response from a portable visible/near-inf
Externí odkaz:
https://doaj.org/article/e44627be6876476f8c86ccf080015265