Zobrazeno 1 - 10
of 519
pro vyhledávání: '"Amato J Giaccia"'
Autor:
Sharareh Gholamin, Osama A Youssef, Marjan Rafat, Rogelio Esparza, Suzana Kahn, Maryam Shahin, Amato J Giaccia, Edward E Graves, Irving Weissman, Siddhartha Mitra, Samuel H Cheshier
Publikováno v:
Innate Immunity, Vol 26 (2020)
Irradiation and temozolomide (TMZ) chemotherapy are the current standard treatments for glioblastoma multiforme (GBM), but they are associated with toxicity and limited efficacy. Recently, these standard therapies have been used to enhance immunother
Externí odkaz:
https://doaj.org/article/3330de0f84114cf79de9647eea0489bb
Epidermal or dermal specific knockout of PHD-2 enhances wound healing and minimizes ischemic injury.
Autor:
Andrew S Zimmermann, Shane D Morrison, Michael S Hu, Shuli Li, Allison Nauta, Michael Sorkin, Nathaniel P Meyer, Graham G Walmsley, Zeshaan N Maan, Denise A Chan, Geoffrey C Gurtner, Amato J Giaccia, Michael T Longaker
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e93373 (2014)
INTRODUCTION:Hypoxia-inducible factor (HIF)-1α, part of the heterodimeric transcription factor that mediates the cellular response to hypoxia, is critical for the expression of multiple angiogenic growth factors, cell motility, and the recruitment o
Externí odkaz:
https://doaj.org/article/66c1a0096a934e2fb2572ea89d7a7aca
Autor:
Christophe Merceron, Laura Mangiavini, Alexander Robling, Tremika LeShan Wilson, Amato J Giaccia, Irving M Shapiro, Ernestina Schipani, Makarand V Risbud
Publikováno v:
PLoS ONE, Vol 9, Iss 10, p e110768 (2014)
The intervertebral disc (IVD) is one of the largest avascular organs in vertebrates. The nucleus pulposus (NP), a highly hydrated and proteoglycan-enriched tissue, forms the inner portion of the IVD. The NP is surrounded by a multi-lamellar fibrocart
Externí odkaz:
https://doaj.org/article/f56df5f2d2f94da6bcb63cdde781539c
Publikováno v:
Frontiers in Endocrinology, Vol 4 (2013)
Bone marrow is a highly heterogeneous and vascularized tissue. The various cell types populating the bone marrow extensively communicate with each other, and cell to cell cross talk is likely to be essential for proper bone development and homeostasi
Externí odkaz:
https://doaj.org/article/5d3617f2ae62451cab5263ab1ebc1ada
Autor:
Katarzyna B. Leszczynska, Monika Dzwigonska, Hala Estephan, Jutta Moehlenbrink, Elizabeth Bowler, Amato J. Giaccia, Jakub Mieczkowski, Bozena Kaminska, Ester M. Hammond
Publikováno v:
Molecular Oncology, Vol 17, Iss 7, Pp 1173-1191 (2023)
Local hypoxia occurs in most solid tumors and is associated with aggressive disease and therapy resistance. Widespread changes in gene expression play a critical role in the biological response to hypoxia. However, most research has focused on hypoxi
Externí odkaz:
https://doaj.org/article/322ae7bae5474bcc992e7a2cd94f8ce2
Autor:
Timothy D. Klasson, Edward L. LaGory, Hongjuan Zhao, Star K. Huynh, Ioanna Papandreou, Eui Jung Moon, Amato J. Giaccia
Publikováno v:
Cancer & Metabolism, Vol 10, Iss 1, Pp 1-17 (2022)
Abstract Background Clear cell renal cell carcinoma (ccRCC), the predominant subtype of kidney cancer, possesses characteristic alterations to multiple metabolic pathways, including the accumulation of cytosolic lipid droplets. However, the pathways
Externí odkaz:
https://doaj.org/article/31c54fc7899d4d009ae61cd9a6805ec7
Autor:
Chun-Lung Chiu, Caiyun G. Li, Erik Verschueren, Ru M. Wen, Dalin Zhang, Catherine A. Gordon, Hongjuan Zhao, Amato J. Giaccia, James D. Brooks
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 7, p 6258 (2023)
Increased expression of NUSAP1 has been identified as a robust prognostic biomarker in prostate cancer and other malignancies. We have previously shown that NUSAP1 is positively regulated by E2F1 and promotes cancer invasion and metastasis. To furthe
Externí odkaz:
https://doaj.org/article/8b7f9b45b212493299a7a5dfc6081550
Autor:
Amato J. Giaccia, Quynh-Thu Le, Daniel T. Chang, Monica M. Olcina, Caiyun G. Li, Michael S. Binkley, Deana Colburg, Rie von Eyben, Vignesh Viswanathan, Dhanya K. Nambiar, Quaovi H. Sodji
Proportion of various immune cell type in TME of pancreatic cancer (TGCA).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f87d4a67ddafdc13b93189ab0a2ffb7
https://doi.org/10.1158/2767-9764.22545558
https://doi.org/10.1158/2767-9764.22545558
Autor:
Amato J. Giaccia, Quynh-Thu Le, Daniel T. Chang, Monica M. Olcina, Caiyun G. Li, Michael S. Binkley, Deana Colburg, Rie von Eyben, Vignesh Viswanathan, Dhanya K. Nambiar, Quaovi H. Sodji
Supplementary Figure S1: Proportion of total NK cell in the tumor microenvironment of 138 pancreatic cancer patients based on the CIBERSORTx analysis of TCGA. Supplementary Figure S2: Immunohistochemical staining of NK cells (Red circle) using NKp46.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba9ce888105d74ea970ff4d26bf0cc22
https://doi.org/10.1158/2767-9764.22545561.v1
https://doi.org/10.1158/2767-9764.22545561.v1
Autor:
Amato J. Giaccia, Edward E. Graves, Quaovi H. Sodji, Yu Xu, Caiyun G. Li, Saravanan Nandagopal
Supplementary figures and legends S1-S8
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09d56d5336fe13598a78f19d39034fa9
https://doi.org/10.1158/2326-6066.22544337
https://doi.org/10.1158/2326-6066.22544337