High burden of viruses and bacterial pathobionts drives heightened nasal innate immunity in children.

Autor: Watkins TA; Department of Laboratory Medicine, Yale School of Medicine, New Haven, CT, USA.; Department of Immunobiology, Yale School of Medicine, New Haven, CT, USA., Green AB; Department of Laboratory Medicine, Yale School of Medicine, New Haven, CT, USA.; Department of Pediatrics, Yale School of Medicine, New Haven, CT, USA., Amat JAR; Department of Laboratory Medicine, Yale School of Medicine, New Haven, CT, USA.; Department of Immunobiology, Yale School of Medicine, New Haven, CT, USA., Cheemarla NR; Department of Laboratory Medicine, Yale School of Medicine, New Haven, CT, USA.; Department of Immunobiology, Yale School of Medicine, New Haven, CT, USA., Hänsel K; Department of Laboratory Medicine, Yale School of Medicine, New Haven, CT, USA., Lozano R; Department of Laboratory Medicine, Yale School of Medicine, New Haven, CT, USA., Dudgeon SN; Department of Laboratory Medicine, Yale School of Medicine, New Haven, CT, USA., Germain G; Department of Pediatrics, Yale School of Medicine, New Haven, CT, USA., Landry ML; Department of Laboratory Medicine, Yale School of Medicine, New Haven, CT, USA.; Department of Medicine, Yale School of Medicine, New Haven, CT, USA., Schulz WL; Department of Laboratory Medicine, Yale School of Medicine, New Haven, CT, USA., Foxman EF; Department of Laboratory Medicine, Yale School of Medicine, New Haven, CT, USA.; Department of Immunobiology, Yale School of Medicine, New Haven, CT, USA.

Publikováno v: The Journal of experimental medicine [J Exp Med] 2024 Sep 02; Vol. 221 (9). Date of Electronic Publication: 2024 Jul 01.

Long-term adaptation following influenza A virus host shifts results in increased within-host viral fitness due to higher replication rates, broader dissemination within the respiratory epithelium and reduced tissue damage.

Autor: Amat JAR; MRC-University of Glasgow Centre for Virus Research, Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, Scotland, United Kingdom.; School of Veterinary Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, Scotland, United Kingdom., Patton V; School of Veterinary Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, Scotland, United Kingdom., Chauché C; MRC-University of Glasgow Centre for Virus Research, Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, Scotland, United Kingdom.; Centre for Inflammation Research, University of Edinburgh, The Queen's Medical Research Institute, Edinburgh, Scotland, United Kingdom., Goldfarb D; MRC-University of Glasgow Centre for Virus Research, Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, Scotland, United Kingdom., Crispell J; MRC-University of Glasgow Centre for Virus Research, Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, Scotland, United Kingdom., Gu Q; MRC-University of Glasgow Centre for Virus Research, Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, Scotland, United Kingdom., Coburn AM; MRC-University of Glasgow Centre for Virus Research, Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, Scotland, United Kingdom., Gonzalez G; MRC-University of Glasgow Centre for Virus Research, Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, Scotland, United Kingdom.; Ecole Nationale Vétérinaire d'Alfort, Université Paris-Est, Maisons-Alfort, France., Mair D; MRC-University of Glasgow Centre for Virus Research, Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, Scotland, United Kingdom., Tong L; MRC-University of Glasgow Centre for Virus Research, Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, Scotland, United Kingdom., Martinez-Sobrido L; Texas Biomedical Research Institute, San Antonio, Texas, United States of America., Marshall JF; School of Veterinary Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, Scotland, United Kingdom., Marchesi F; School of Veterinary Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, Scotland, United Kingdom., Murcia PR; MRC-University of Glasgow Centre for Virus Research, Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, Scotland, United Kingdom.

Publikováno v: PLoS pathogens [PLoS Pathog] 2021 Dec 17; Vol. 17 (12), pp. e1010174. Date of Electronic Publication: 2021 Dec 17 (Print Publication: 2021).

Severe Acute Respiratory Syndrome Coronavirus 2 Serosurveillance in a Patient Population Reveals Differences in Virus Exposure and Antibody-Mediated Immunity According to Host Demography and Healthcare Setting.

Autor: Hughes EC; MRC-University of Glasgow Centre for Virus Research, Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom.; Institute of Biodiversity, Animal Health and Comparative Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom., Amat JAR; MRC-University of Glasgow Centre for Virus Research, Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom.; School of Veterinary Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom., Haney J; MRC-University of Glasgow Centre for Virus Research, Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom., Parr YA; MRC-University of Glasgow Centre for Virus Research, Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom., Logan N; MRC-University of Glasgow Centre for Virus Research, Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom., Palmateer N; Public Health Scotland (Health Protection Scotland), Glasgow, United Kingdom.; School of Health $ Life Sciences, Glasgow Caledonian University, Glasgow, United Kingdom., Nickbakhsh S; MRC-University of Glasgow Centre for Virus Research, Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom., Ho A; MRC-University of Glasgow Centre for Virus Research, Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom., Cherepanov P; Chromatin Structure and Mobile DNA Laboratory, The Francis Crick Institute, London, United Kingdom.; Department of Medicine, Imperial College London, St Mary's Campus, London, UK., Rosa A; Chromatin Structure and Mobile DNA Laboratory, The Francis Crick Institute, London, United Kingdom., McAuley A; Public Health Scotland (Health Protection Scotland), Glasgow, United Kingdom.; School of Health $ Life Sciences, Glasgow Caledonian University, Glasgow, United Kingdom., Broos A; MRC-University of Glasgow Centre for Virus Research, Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom.; Institute of Biodiversity, Animal Health and Comparative Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom., Herbert I; MRC-University of Glasgow Centre for Virus Research, Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom., Arthur U; MRC-University of Glasgow Centre for Virus Research, Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom., Szemiel AM; MRC-University of Glasgow Centre for Virus Research, Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom., Roustan C; Chromatin Structure and Mobile DNA Laboratory, The Francis Crick Institute, London, United Kingdom., Dickson E; Public Health Scotland (Health Protection Scotland), Glasgow, United Kingdom., Gunson RN; West of Scotland Specialist Virology Centre, NHS Greater Glasgow and Clyde, Glasgow, United Kingdom., Viana M; Institute of Biodiversity, Animal Health and Comparative Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom., Willett BJ; MRC-University of Glasgow Centre for Virus Research, Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom., Murcia PR; MRC-University of Glasgow Centre for Virus Research, Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom.

Publikováno v: The Journal of infectious diseases [J Infect Dis] 2021 Mar 29; Vol. 223 (6), pp. 971-980.