Hepcidin-guided screen-and-treat interventions against iron-deficiency anaemia in pregnancy: a randomised controlled trial in The Gambia

Autor: Amat Bah, PhD, Abdul Khalie Muhammad, MSc, Rita Wegmuller, PhD, Hans Verhoef, PhD, Morgan M Goheen, MD, Saikou Sanyang, BSc, Ebrima Danso, BSc, Ebrima A Sise, BSc, Sant-Rayn Pasricha, MD, Andrew E Armitage, PhD, Hal Drakesmith, ProfPhD, James H Cross, BSc, Sophie E Moore, PhD, Carla Cerami, Andrew M Prentice, ProfPhD

Publikováno v: The Lancet Global Health, Vol 7, Iss 11, Pp e1564-e1574 (2019)

Summary: Background: WHO recommends daily iron supplementation for pregnant women, but adherence is poor because of side-effects, effectiveness is low, and there are concerns about possible harm. The iron-regulatory hormone hepcidin can signal when a

Externí odkaz: https://doaj.org/article/2c6a9b6a9ae148cfbda39a774621a425

Hepcidin-guided screen-and-treat interventions against iron-deficiency anaemia in pregnancy: a randomised controlled trial in The Gambia

Autor: James H. Cross, Carla Cerami, Andrew M. Prentice, Morgan M. Goheen, Ebrima A. Sise, Sophie E. Moore, Rita Wegmüller, Andrew E. Armitage, Hans Verhoef, Sant-Rayn Pasricha, Amat Bah, Saikou Sanyang, Hal Drakesmith, Ebrima Danso, Abdul Khalie Muhammad

Publikováno v: The Lancet Global Health 7 (2019) 11
The Lancet Global Health, 7(11), e1564-e1574
The Lancet Global Health, Vol 7, Iss 11, Pp e1564-e1574 (2019)

Summary: Background: WHO recommends daily iron supplementation for pregnant women, but adherence is poor because of side-effects, effectiveness is low, and there are concerns about possible harm. The iron-regulatory hormone hepcidin can signal when a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f4e441f222f21a61b5151274d537d81
https://doi.org/10.1016/s2214-109x(19)30393-6

Respiratory infections drive hepcidin-mediated blockade of iron absorption leading to iron deficiency anemia in African children

Autor: Miriam Wathuo, Rita Wegmüller, Carla Cerami, Kabiru Ceesay, Noah J. Kessler, Amadou T. Jallow, Hal Drakesmith, Sant-Rayn Pasricha, Ebrima A. Sise, Andrew E. Armitage, Amat Bah, Andrew M. Prentice, Saikou Sanyang, Momodou W. Jallow, Ebrima Danso

Publikováno v: Science Advances
Science Advances, 5 (3)

Inflammation from respiratory infections contributes to iron deficiency anemia in children by blocking iron absorption.
Iron deficiency anemia (IDA) is the most prevalent nutritional condition worldwide. We studied the contribution of hepcidin-m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89cf9ac5354734d85d6da8d4d1b916d8
https://pubmed.ncbi.nlm.nih.gov/30944864

Efficacy and safety of hepcidin-based screen-and-treat approaches using two different doses versus a standard universal approach of iron supplementation in young children in rural Gambia: a double-blind randomised controlled trial

Autor: Sarah Mulwa, Amat Bah, Rita Wegmüller, Morgan M. Goheen, Diego Moretti, Lindsay Kendall, Andrew M. Prentice, Carla Cerami

Publikováno v: BMC Pediatrics, 16
BMC Pediatrics

Background Iron deficiency prevalence rates frequently exceed 50 % in young children in low-income countries. The World Health Organization (WHO) recommended universal supplementation of young children where anaemia rates are >40 %. However, large ra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::371131d59cdef14c95330e50ddbca8bc
https://hdl.handle.net/20.500.11850/120736