Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Amarjit Nijjar"'
Autor:
Ralph Mazitschek, Amarjit Nijjar, Joseph F. Cortese, Erin Tyndall, Jon Clardy, Derek C. Martyn, Hanlan Liu, Thomas O'Shea, Maria Fitzgerald, Sanjay Danthi, Cassandra Celatka
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:228-231
Two sets of diaminopyrimidines, totalling 45 compounds, were synthesized and assayed against Plasmodium falciparum. The SAR was relatively shallow, with only the presence of a 2-(pyrrolidin-1-yl)ethyl group at R2 significantly affecting activity. A s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25f13f914cf4dd4ff58b0b07588f2e1c
https://doi.org/10.1016/j.bmcl.2009.10.133
https://doi.org/10.1016/j.bmcl.2009.10.133
Autor:
Hanlan Liu, Margaret A. Phillips, Erin K. Willert, Yibin Xiang, Jeffrey D. Klinger, Bakela Nare, Bradford H. Hirth, Amarjit Nijjar, Cassandra Celatka, Edmund Sybertz, Robert H. Barker
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:2916-2919
Modification of the structure of trypanosomal AdoMetDC inhibitor 1 (MDL73811) resulted in the identification of a new inhibitor 7a, which features a methyl substituent at the 8-position. Compound 7a exhibits improved potencies against both the trypan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4d03fcaf297b21c70c293f0de3a8d8b
https://doi.org/10.1016/j.bmcl.2009.04.096
https://doi.org/10.1016/j.bmcl.2009.04.096