Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Amarjit Bhomra"'
Autor:
Anna J Kordala, Jessica Stoodley, Nina Ahlskog, Muhammad Hanifi, Antonio Garcia Guerra, Amarjit Bhomra, Wooi Fang Lim, Lyndsay M Murray, Kevin Talbot, Suzan M Hammond, Matthew JA Wood, Carlo Rinaldi
Publikováno v:
EMBO Molecular Medicine, Vol 15, Iss 11, Pp n/a-n/a (2023)
Abstract Spinal muscular atrophy (SMA) is a leading genetic cause of infant mortality. The advent of approved treatments for this devastating condition has significantly changed SMA patients' life expectancy and quality of life. Nevertheless, these a
Externí odkaz:
https://doaj.org/article/0a6be327d14849d1ae2a1fc49bf73886
Autor:
Tirsa L.E. vanWestering, Yulia Lomonosova, Anna M.L. Coenen‐Stass, Corinne A. Betts, Amarjit Bhomra, Margriet Hulsker, Lucy E. Clark, Graham McClorey, Annemieke Aartsma‐Rus, Maaike vanPutten, Matthew J.A. Wood, Thomas C. Roberts
Publikováno v:
Journal of Cachexia, Sarcopenia and Muscle, Vol 11, Iss 2, Pp 578-593 (2020)
Abstract Background Duchenne muscular dystrophy (DMD) is a fatal muscle‐wasting disorder caused by genetic loss of dystrophin protein. Extracellular microRNAs (ex‐miRNAs) are putative, minimally invasive biomarkers of DMD. Specific ex‐miRNAs (e
Externí odkaz:
https://doaj.org/article/f3627d2febcc4bb89cb45a178fc1a87b
Autor:
Anna M.L. Coenen-Stass, Helena Sork, Sole Gatto, Caroline Godfrey, Amarjit Bhomra, Kaarel Krjutškov, Jonathan R. Hart, Jakub O. Westholm, Liz O’Donovan, Andreas Roos, Hanns Lochmüller, Pier Lorenzo Puri, Samir EL Andaloussi, Matthew J.A. Wood, Thomas C. Roberts
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 13, Iss , Pp 1-15 (2018)
Extracellular small RNAs (sRNAs), including microRNAs (miRNAs), are promising biomarkers for diseases such as Duchenne muscular dystrophy (DMD), although their biological relevance is largely unknown. To investigate the relationship between intracell
Externí odkaz:
https://doaj.org/article/dc55244590fd44329400bbee0db3a420
Autor:
Avigail Agam, Binnaz Yalcin, Amarjit Bhomra, Matthew Cubin, Caleb Webber, Christopher Holmes, Jonathan Flint, Richard Mott
Publikováno v:
PLoS ONE, Vol 5, Iss 9, p e12839 (2010)
Array comparative genomic hybridization (aCGH) to detect copy number variants (CNVs) in mammalian genomes has led to a growing awareness of the potential importance of this category of sequence variation as a cause of phenotypic variation. Yet there
Externí odkaz:
https://doaj.org/article/8e7712a66c8a497facc3a86bcb072c55
Autor:
Binnaz Yalcin, Jérôme Nicod, Amarjit Bhomra, Stuart Davidson, James Cleak, Laurent Farinelli, Magne Østerås, Adam Whitley, Wei Yuan, Xiangchao Gan, Martin Goodson, Paul Klenerman, Ansu Satpathy, Diane Mathis, Christophe Benoist, David J Adams, Richard Mott, Jonathan Flint
Publikováno v:
PLoS Genetics, Vol 6, Iss 9, p e1001085 (2010)
Genome-wide association studies using commercially available outbred mice can detect genes involved in phenotypes of biomedical interest. Useful populations need high-frequency alleles to ensure high power to detect quantitative trait loci (QTLs), lo
Externí odkaz:
https://doaj.org/article/893a7a8c230343ea998a9bb575a83011
Autor:
Anna Kordala, Nina Ahlskog, Muhammad Hanifi, Amarjit Bhomra, Jessica Stoodley, Wooi Fang Lim, Suzan Hammond, Matthew JA Wood, Carlo Rinaldi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6317e9ff0be915f39fc4fb1ec8e95b4d
https://doi.org/10.15252/rc.2023679961
https://doi.org/10.15252/rc.2023679961
Autor:
Anna J Kordala, Nina Ahlskog, Muhammad Hanifi, Amarjit Bhomra, Jessica Stoodley, Wooi Fang Lim, Suzan M Hammond, Matthew JA Wood, Carlo Rinaldi
Spinal muscular atrophy (SMA) is the leading genetic cause of infant mortality. The advent of approved treatments for this devastating condition has significantly changed SMA patients’ life expectancy and quality of life. Nevertheless, these are no
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::943f18cf3ca9441b65a325abb5e18a09
https://doi.org/10.1101/2022.10.18.512489
https://doi.org/10.1101/2022.10.18.512489
Autor:
Wooi F. Lim, Melissa Bowerman, Corinne A. Betts, Lara Cravo, Aarti Jagannath, Tirsa L.E. van Westering, Jinhong Meng, Katarzyna Chwalenia, Russell G. Foster, Jennifer E. Morgan, Carlo Rinaldi, Maria Sofia Falzarano, Elizabeth O’Donovan, Alessandra Ferlini, Graham McClorey, Katharina E. Meijboom, John R. Counsell, Amarjit Bhomra, Matthew J.A. Wood, Michael J. Gait, Amer F. Saleh, Subhashis Banerjee
Publikováno v:
Life Science Alliance
Absence of integral sarcolemmal protein, dystrophin, disrupts the RhoA-actin-SRF cascade in skeletal muscle, with subsequent dysregulation of downstream-SRF circadian targets and circadian rhythm.
Absence of dystrophin, an essential sarcolemmal
Absence of dystrophin, an essential sarcolemmal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d711e18ebfc93027b1f5621297a5949
https://doi.org/10.26508/lsa.202101014
https://doi.org/10.26508/lsa.202101014
Autor:
Katarzyna Chwalenia, O'Donovan E, Russell G. Foster, Carlo Rinaldi, Graham McClorey, Soumya Banerjee, John R. Counsell, Jennifer E. Morgan, van Westering T, Saleh A, Lara Cravo, Jinhong Meng, Maria Sofia Falzarano, Melissa Bowerman, Matthew J.A. Wood, Corinne A. Betts, Lim C, Aarti Jagannath, Amarjit Bhomra, Gait Mj, Katharina E. Meijboom, Ferlini A
Dystrophin is a sarcolemmal protein essential for muscle contraction and maintenance, absence of which leads to the devastating muscle wasting disease Duchenne muscular dystrophy (DMD)[1, 2]. Dystrophin has an actin-binding domain [3–5], which spec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6df05f9556e61c91f786cd9c81c5d733
https://doi.org/10.1101/2021.06.23.449492
https://doi.org/10.1101/2021.06.23.449492
Autor:
Lucy E Clark, Yulia Lomonosova, Amarjit Bhomra, Annemieke Aartsma-Rus, Anna M.L. Coenen-Stass, Margriet Hulsker, Tirsa L.E. van Westering, Thomas C. Roberts, Graham McClorey, Corinne A. Betts, Matthew J.A. Wood, Maaike van Putten
Publikováno v:
Journal of Cachexia, Sarcopenia and Muscle, Vol 11, Iss 2, Pp 578-593 (2020)
Journal of Cachexia, Sarcopenia and Muscle, 11(2), 578-593. WILEY
Journal of Cachexia, Sarcopenia and Muscle
Journal of Cachexia, Sarcopenia and Muscle, 11(2), 578-593. WILEY
Journal of Cachexia, Sarcopenia and Muscle
Background:Duchenne muscular dystrophy (DMD) is a fatal muscle‐wasting disorder caused by genetic loss of dystrophin protein. Extracellular microRNAs (ex‐miRNAs) are putative, minimally invasive biomarkers of DMD. Specific ex‐miRNAs (e.g. miR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb13a752d993c0eb60ef9cbcd522405d
https://hdl.handle.net/1887/3185204
https://hdl.handle.net/1887/3185204