Tick-borne encephalitis vaccine breakthrough infections induce aberrant T cell and antibody responses to non-structural proteins

Autor: Amare Aregay, Jan Slunečko, Miša Korva, Petra Bogovic, Katarina Resman Rus, Nataša Knap, Jana Beicht, Mareike Kubinski, Giulietta Saletti, Tatjana Avšič-Županc, Imke Steffen, Franc Strle, Albert D. M. E. Osterhaus, Guus F. Rimmelzwaan

Publikováno v: npj Vaccines, Vol 9, Iss 1, Pp 1-9 (2024)

Abstract Tick-borne encephalitis virus (TBEV) vaccine breakthrough (VBT) infections are not uncommon in endemic areas. The clinical and immunological outcomes have been poorly investigated. We assessed the magnitude and specificity of virus-specific

Externí odkaz: https://doaj.org/article/cf5b01988b3348ca856aae149d908d63

Immunity to Tick-Borne Encephalitis Virus NS3 Protein Induced with a Recombinant Modified Vaccinia Virus Ankara Fails to Afford Mice Protection against TBEV Infection

Autor: Mareike Kubinski, Jana Beicht, Thomas Gerlach, Amare Aregay, Albert D. M. E. Osterhaus, Alina Tscherne, Gerd Sutter, Chittappen Kandiyil Prajeeth, Guus F. Rimmelzwaan

Publikováno v: Vaccines, Vol 12, Iss 1, p 105 (2024)

Tick-borne encephalitis (TBE) is a serious neurological disease caused by TBE virus (TBEV). Because antiviral treatment options are not available, vaccination is the key prophylactic measure against TBEV infections. Despite the availability of effect

Externí odkaz: https://doaj.org/article/6995d27a9c67459589803e595b8ce85e

Distinct Immune Imprints of Post-Liver Transplantation Hepatitis C Persist Despite Viral Clearance

Autor: Markus Cornberg, Richard Taubert, Kerstin Port, Christian E. Niehaus, Bastian Engel, Birgit Bremer, Nicolas Richter, Florian W. R. Vondran, Tanvi Khera, Heiner Wedemeyer, Elmar Jaeckel, Amare Aregay

Publikováno v: Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society
United States

Recurrence or de novo infection of hepatitis C virus (HCV) after liver transplantation (LT) has been associated with progressive graft hepatitis that can be improved by treatment with novel direct-acting antivirals. Cases of rejection episodes have b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbf6d3851f04afc6b46bbed839d76e84
https://hdl.handle.net/10033/622949

Systemic inflammation and immune cell phenotypes are associated with neuro-psychiatric symptoms in patients with chronic inflammatory liver diseases

Autor: Michael P. Manns, Markus Cornberg, Heiner Wedemeyer, Kim Haag, Birgit Bremer, Meike Dirks, Karin Weissenborn, Henning Pflugrad, Julia Hengst, Ramona Schuppner, Verena Schlaphoff, Christine S. Falk, Amare Aregay, Solomon Owusu Sekyere

Background & aims Chronic inflammatory liver diseases are frequently associated with neuropsychiatric and cognitive dysfunctions. We hypothesized that symptomatic patients may show altered levels of soluble inflammatory mediators (SIMs) as well as ch

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6776efc8072826446d4716b07a9803cc
https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&origin=inward&scp=85057173254

Interferon-free cure of hepatitis C virus infection does alter the soluble inflammatory milieu which could affect hepatocellular carcinoma surveillance by CD8+ T cells in patients with liver cirrhosis

Autor: Bernhard Schlevogt, Katja Deterding, Thomas Wirth, M. Cornberg, Arndt Vogel, H. Wedemeyer, Solomon Owusu Sekyere, Christine S. Falk, M.P. Manns, Amare Aregay

Publikováno v: Journal of Hepatology. 66:S2

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::819bc5f66dba80e7ef20f42584335397
https://doi.org/10.1016/s0168-8278(17)30266-0