Zobrazeno 1 - 10
of 72
pro vyhledávání: '"Amardeep S Dhillon"'
Autor:
Laura J. Jenkins, Ian Y. Luk, Fiona Chionh, Tao Tan, Kristen Needham, Jamieson Ayton, Camilla M. Reehorst, Natalia Vukelic, Oliver M. Sieber, Dmitri Mouradov, Peter Gibbs, David S. Williams, Niall C. Tebbutt, Jayesh Desai, Frédéric Hollande, Amardeep S. Dhillon, Erinna F. Lee, Delphine Merino, W. Douglas Fairlie, John M. Mariadason
Publikováno v:
Cell Death and Disease, Vol 15, Iss 3, Pp 1-9 (2024)
Abstract Metastatic BRAF V600E colorectal cancer (CRC) carries an extremely poor prognosis and is in urgent need of effective new treatments. While the BRAFV600E inhibitor encorafenib in combination with the EGFR inhibitor cetuximab (Enc+Cet) was rec
Externí odkaz:
https://doaj.org/article/6e4f88d9b616433e88bdbae69ee002cc
Autor:
Jeannine Diesch, Elaine Sanij, Omer Gilan, Christopher Love, Hoanh Tran, Nicholas I Fleming, Jason Ellul, Marcia Amalia, Izhak Haviv, Richard B Pearson, Eugene Tulchinsky, John M Mariadason, Oliver M Sieber, Ross D Hannan, Amardeep S Dhillon
Publikováno v:
PLoS ONE, Vol 9, Iss 3, p e88950 (2014)
Tumor invasion and metastasis involves complex remodeling of gene expression programs governing epithelial homeostasis. Mutational activation of the RAS-ERK is a frequent occurrence in many cancers and has been shown to drive overexpression of the AP
Externí odkaz:
https://doaj.org/article/d7fe9ee98a4f408bb231db36ea198d14
Autor:
Lars Tögel, Rebecca Nightingale, Rui Wu, Anderly C. Chüeh, Sheren Al-Obaidi, Ian Luk, Mercedes Dávalos-Salas, Fiona Chionh, Carmel Murone, Daniel D. Buchanan, Zac Chatterton, Oliver M. Sieber, Diego Arango, Niall C. Tebbutt, David Williams, Amardeep S. Dhillon, John M. Mariadason
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-2 (2023)
Externí odkaz:
https://doaj.org/article/2da398f3b9b94697999c98041af917de
Autor:
Khadizatul Kubra, Gurveer K. Gaddu, Clifford Liongue, Somayyeh Heidary, Alister C. Ward, Amardeep S. Dhillon, Faiza Basheer
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 17, p 10098 (2022)
Members of the FOS protein family regulate gene expression responses to a multitude of extracellular signals and are dysregulated in several pathological states. Whilst mouse genetic models have provided key insights into the tissue-specific function
Externí odkaz:
https://doaj.org/article/c663f0091f754f87a5301f672b2a9094
Autor:
John M. Mariadason, Andrew K. Shiau, Panagis Filippakopoulos, Timothy C. Gahman, Beatriz Diez-Dacal, Mark A. Dawson, Amardeep S. Dhillon, Diego Arango, Oliver M. Sieber, Rui Wu, Toby Phesse, Hoanh Tran, Aparna Jayachandran, Anderly C. Chueh, Rebecca Nightingale, Lars Tögel
Genotypes of colorectal cancer cell lines.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28b8da6d55007eda7753d09a5e5bcc2d
https://doi.org/10.1158/1535-7163.22503354.v1
https://doi.org/10.1158/1535-7163.22503354.v1
Autor:
John M. Mariadason, Niall C. Tebbutt, Amardeep S. Dhillon, Oliver M. Sieber, Peter Gibbs, Jayesh Desai, Shoukat Afshar-Sterle, Matthias Ernst, George Iatropoulos, Fiona Chionh, Zakia Alam, Rebecca Nightingale, Janson W.T. Tse, Sharon Tran, Natalia Vukelic, Irvin Ng, Tao Tan, Kael L. Schoffer, Michelle Palmieri, Erinna F. Lee, W. Douglas Fairlie, Ian Y. Luk, Laura J. Jenkins
Supplementary figure 3 shows combining trametinib with different classes of HDAC inhibitors in COLO 201 cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f1dc90f3d860b1fbfdaa44e2471d7bc
https://doi.org/10.1158/1535-7163.22523094
https://doi.org/10.1158/1535-7163.22523094
Autor:
John M. Mariadason, Niall C. Tebbutt, Amardeep S. Dhillon, Oliver M. Sieber, Peter Gibbs, Jayesh Desai, Shoukat Afshar-Sterle, Matthias Ernst, George Iatropoulos, Fiona Chionh, Zakia Alam, Rebecca Nightingale, Janson W.T. Tse, Sharon Tran, Natalia Vukelic, Irvin Ng, Tao Tan, Kael L. Schoffer, Michelle Palmieri, Erinna F. Lee, W. Douglas Fairlie, Ian Y. Luk, Laura J. Jenkins
The EGFR/RAS/MEK/ERK signaling pathway (ERK/MAPK) is hyperactivated in most colorectal cancers. A current limitation of inhibitors of this pathway is that they primarily induce cytostatic effects in colorectal cancer cells. Nevertheless, these drugs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24d7f3c002fb3adda7bdadd360c35bd5
https://doi.org/10.1158/1535-7163.c.6543591
https://doi.org/10.1158/1535-7163.c.6543591
Autor:
John M. Mariadason, Andrew K. Shiau, Panagis Filippakopoulos, Timothy C. Gahman, Beatriz Diez-Dacal, Mark A. Dawson, Amardeep S. Dhillon, Diego Arango, Oliver M. Sieber, Rui Wu, Toby Phesse, Hoanh Tran, Aparna Jayachandran, Anderly C. Chueh, Rebecca Nightingale, Lars Tögel
BET protein expression in primary colorectal cancers.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::394a875cf8e6b1fce6ef1625bfc985dc
https://doi.org/10.1158/1535-7163.22503369.v1
https://doi.org/10.1158/1535-7163.22503369.v1
Autor:
John M. Mariadason, Andrew K. Shiau, Panagis Filippakopoulos, Timothy C. Gahman, Beatriz Diez-Dacal, Mark A. Dawson, Amardeep S. Dhillon, Diego Arango, Oliver M. Sieber, Rui Wu, Toby Phesse, Hoanh Tran, Aparna Jayachandran, Anderly C. Chueh, Rebecca Nightingale, Lars Tögel
Legends to supplementary Figures
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c13e69bbd0075c023ab693f86e66ebb
https://doi.org/10.1158/1535-7163.22503360.v1
https://doi.org/10.1158/1535-7163.22503360.v1
Autor:
John M. Mariadason, Andrew K. Shiau, Panagis Filippakopoulos, Timothy C. Gahman, Beatriz Diez-Dacal, Mark A. Dawson, Amardeep S. Dhillon, Diego Arango, Oliver M. Sieber, Rui Wu, Toby Phesse, Hoanh Tran, Aparna Jayachandran, Anderly C. Chueh, Rebecca Nightingale, Lars Tögel
BET protein expression in 20 colon cancer cell lines.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4979ff1fb1c08dcdf49f5c1bd12cd134
https://doi.org/10.1158/1535-7163.22503372
https://doi.org/10.1158/1535-7163.22503372