Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Amarbirpal Mahal"'
Autor:
Donna L. Smith, Ruben Portier, Ben Woodman, Emma Hockly, Amarbirpal Mahal, William E. Klunk, Xiao-Jiang Li, Erich Wanker, Karl D. Murray, Gillian P. Bates
Publikováno v:
Neurobiology of Disease, Vol 8, Iss 6, Pp 1017-1026 (2001)
Huntington's disease (HD) is a late onset neurodegenerative disorder caused by a CAG/polyglutamine (polyQ) repeat expansion. PolyQ aggregates can be detected in the nuclei and processes of neurons in HD patients and mouse models prior to the onset of
Externí odkaz:
https://doaj.org/article/fa08d20b29484b8d8f8a3bbfc905b226
Autor:
Richard Mott, Amarbirpal Mahal, Kirupa Sathasivam, Laura Mangiarini, Gillian P. Bates, Mary J. Seller
Six inherited neurodegenerative diseases are caused by a CAG/polyglutamine expansion, including spinal and bulbar muscular atrophy (SBMA), Huntington's disease (HD), spinocerebellar ataxia type 1 (SCA1), dentatorubral pallidoluysian atrophy (DRPLA) M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82de93d3984f5fae0e29c2cb9d98e2dc
https://ora.ox.ac.uk/objects/uuid:c03ae7c0-40b6-4e46-b00f-fd1ba5ac5595
https://ora.ox.ac.uk/objects/uuid:c03ae7c0-40b6-4e46-b00f-fd1ba5ac5595
Autor:
Gillian P. Bates, Shabnam Ghazi-Noori, Donna L. Smith, Kirupa Sathasivam, Philip A. S. Lowden, Benjamin Woodman, Emma Hockly, Amarbirpal Mahal
Publikováno v:
Annals of Neurology. 54:186-196
Huntington's Disease (HD) is an inherited neurological disorder causing movement impairment, personality changes, dementia, and premature death, for which there is currently no effective therapy. The modified tetracycline antibiotic, minocycline, has
Publikováno v:
Molecular and Cellular Neuroscience. 20:638-648
Motor and cognitive deficits in Huntington's disease (HD) are likely caused by progressive neuronal dysfunction preceding neuronal cell death. Synapsin I is one of the major phosphoproteins regulating neurotransmitter release. We report here an abnor
Autor:
Amarbirpal Mahal, Stephen B. Dunnett, Laura Mangiarini, Lisa Lione, A. Jennifer Morton, Kerry P.S.J. Murphy, Gillian P. Bates, Rebecca J. Carter
Publikováno v:
The Journal of Neuroscience. 20:5115-5123
Huntington's disease (HD) is an autosomal dominant progressive and fatal neurodegenerative brain disorder caused by an expanded CAG/polyglutamine repeat in the coding region of the gene. Presymptomatic Huntington's disease patients often exhibit cogn
Autor:
Amarbirpal Mahal, J Workman, JM Cooper, L Mangiarini, Paul E. Hart, Gillian P. Bates, Sarah J. Tabrizi, Anthony H.V. Schapira
Publikováno v:
Annals of Neurology. 47:80-86
Huntington's disease is a progressive neurodegenerative disease caused by an abnormally expanded (>36) CAG repeat within the ITI5 gene encoding a widely expressed 349-kd protein, huntingtin. The medium spiny neurons of the caudate preferentially dege
Autor:
Gillian P. Bates, Amarbirpal Mahal, Erich E. Wanker, Carl Hobbs, Kirupa Sathasivam, Stephen W. Davies, Fabien Bertaux, Patrick Doherty, Laura Mangiarini, Mark Turmaine
Publikováno v:
Scopus-Elsevier
Huntington's disease (HD) is one of a class of inherited progressive neurodegenerative disorders that are caused by a CAG/polyglutamine repeat expansion. We have previously generated mice that are transgenic for exon 1 of the HD gene carrying highly
Publikováno v:
Brain Research. 805:234-240
Huntington's disease transgenic mice were tested in the elevated plus-maze test of anxiety at 6, 8, 10 and 12 weeks of age. At all ages, they showed significant and striking increases in the percentages of open arm entries and time spent on the open
Autor:
Gavin Sherlock, Amarbirpal Mahal, Jia-Ching Shieh, John Rosamond, A. Majeed Bahman, Miguel Godinho Ferreira
Publikováno v:
Molecular and General Genetics MGG. 245:716-723
In the budding yeast Saccharomyces cerevisiae, progress of the cell cycle beyond the major control point in G1 phase, termed START, requires activation of the evolutionarily conserved Cdc28 protein kinase by direct association with G1 cyclins. We hav
Autor:
Sönke Tobaben, Kirupa Sathasivam, Ruben Mestril, Ben Woodman, Michael S. Marber, Gillian P. Bates, David G. Hay, Amarbirpal Mahal, Bernd Stahl, Donna L. Smith
Publikováno v:
Human molecular genetics. 13(13)
The manipulation of chaperone levels has been shown to inhibit aggregation and/or rescue cell death in Saccharomyces cerevisiae, Caenorhabditis elegans, Drosophila melanogaster and cell culture models of Huntington's disease (HD) and other polyglutam