Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Amar S. Prashad"'
Autor:
Renée Procopio-Melino, Frank W. Kotch, Amar S. Prashad, Jose M. Gomes, Wenge Wang, Bo Arve, Andrew Dawdy, Lawrence Chen, Justin Sperry, Christine Hosselet, Tao He, Ronald Kriz, Laura Lin, Kimberly Marquette, Lioudmila Tchistiakova, Will Somers, Jason C. Rouse, Xiaotian Zhong
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract Next-generation site-specific cysteine-based antibody–drug-conjugates (ADCs) broaden therapeutic index by precise drug-antibody attachments. However, manufacturing such ADCs for clinical validation requires complex full reduction and reoxi
Externí odkaz:
https://doaj.org/article/5cda877d16ac4d3e838e8490f8f4c4f8
Autor:
Verl Sriskanda, Amar S. Prashad, Ivette Carino, Janine De Leon, Brenda Carrillo Conde, Seyed Pouria Motevalian, Bo Arve, Jonathan Steen
Publikováno v:
Biotechnology Progress. 37
Over the past decade, single-use tangential flow filtration (TFF) technologies have emerged to reduce system preparation time, promote fast and flexible product change over, and ultimately shorten process development and manufacturing time/cost. In t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9acc6eb121bd8f8f80f133dce3c6f7b3
https://doi.org/10.1002/btpr.3204
https://doi.org/10.1002/btpr.3204
Autor:
April Xu, Bo Arve, Leo Joseph Letendre, Amar S. Prashad, Patel Vimalkumar Babubhai, Birte Nolting
Publikováno v:
Organic Process Research & Development. 21:590-600
In the development of new antibody drug conjugates (ADCs), the activities performed by discovery groups typically focus on the rapid and comprehensive screening of many conjugates to find the ones with the desired efficacy and safety profiles. These
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4c85389f5034a95f017f206f07ff9faa
https://doi.org/10.1021/acs.oprd.7b00020
https://doi.org/10.1021/acs.oprd.7b00020
Autor:
Amy Tam, Aaron M. D’Antona, Tao He, Yen-Tung Luan, Laura Lin, Wenge Wang, Darren Ferguson, Xiaotian Zhong, Lioudmila Tchistiakova, Eric Sousa, Scott Gatto, Amar S. Prashad, Ronald Kriz, Weijun Ma, Jing Zhou, Bo Arve, William S. Somers, Justin Cohen, Richard Zollner
Publikováno v:
Journal of biotechnology. 248
Protein modifications by intricate cellular machineries often redesign the structure and function of existing proteins to impact biological networks. Disulfide bond formation between cysteine (Cys) pairs is one of the most common modifications found
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::457002961c0ca7824988d539bf84331d
https://pubmed.ncbi.nlm.nih.gov/28300660
https://pubmed.ncbi.nlm.nih.gov/28300660
Autor:
Amar S, Prashad, Daniel, Wang, Joan, Subrath, Biqi, Wu, Melissa, Lin, Mei-Yi, Zhang, Natasha, Kagan, Julie, Lee, Xiaoke, Yang, Agnes, Brennan, Divya, Chaudhary, Xin, Xu, Louis, Leung, Jack, Wang, Diane H, Boschelli
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:5799-5802
We previously reported that a 3-pyridinecarbonitrile analog with a furan substituent at C-5 and a 4-methylindol-5-ylamino substituent at C-4, 1, was a potent inhibitor of PKCtheta (IC50=4.5 nM). Replacement of the C-5 furan ring of 1 with bicyclic he
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33fb5d32670093c268bff0f3439545d0
https://doi.org/10.1016/j.bmcl.2009.07.113
https://doi.org/10.1016/j.bmcl.2009.07.113
Autor:
Julie Lee, Daniel Wang, Biqi Wu, Agnes Brennan, Amar S. Prashad, Joan Subrath, Diane H. Boschelli, Chuan Niu, Xiaoke Yang, Divya Chaudhary
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:3623-3626
The key intermediate, 4-chloro-5-iodo-3-pyridinecarbonitrile, allowed for ready optimization of the PKCtheta inhibitory activity of a series of 3-pyridinecarbonitriles. Analog 13b with a 4-methylindol-5-ylamino group at C-4 and a 4-(2-(4-methylpipera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d66e233cc18681ba89e30e82a39014e
https://doi.org/10.1016/j.bmcl.2009.04.126
https://doi.org/10.1016/j.bmcl.2009.04.126
Publikováno v:
Tetrahedron. 65:57-61
A regio- and stereoselective synthesis of 7-( E )-alkenyl-4-amino-3-quinolinecarbonitriles via Pd-mediated coupling reactions was developed. The comparison and optimization of stereoselectivity of the Heck, Stille, and Suzuki reactions of 7-bromo or
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c5ee5bebdabd9275241e5100cc85db47
https://doi.org/10.1016/j.tet.2008.10.063
https://doi.org/10.1016/j.tet.2008.10.063
Autor:
Kevin J. Curran, Boris Feld, Amar S. Prashad, Anita Y. M. Howe, John O'Connell, Martin Joseph Digrandi, Atul Agarwal, Alan G. Sutherland, Bloom Jonathan David, Bernard Dean Johnson, Thomas Nittoli, Shabana Insaf, Rajiv Chopra, Mark Orlowski, Karen L. Wheless, M. Brawner Floyd, Tarek S. Mansour
Publikováno v:
Journal of Medicinal Chemistry. 50:2108-2116
A series of potent anthranilic acid-based inhibitors of the hepatitis C NS5B polymerase has been identified. The inhibitors bind to a site on NS5B between the thumb and palm regions adjacent to the active site as determined by X-ray crystallography o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08d843b4f6fb3ee7a84d885c687abc2c
https://doi.org/10.1021/jm061428x
https://doi.org/10.1021/jm061428x
Autor:
Amar S. Prashad, Vincent Sandanayaka
Publikováno v:
Current Medicinal Chemistry. 9:1145-1165
Resistance to antibiotics is currently a major health concern in treating infectious diseases. The most common mechanism of resistance to beta-lactam antibiotics is the production of beta-lactamases, which destroy beta-lactam antibiotics before they
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8206ef0200447adf66a93fca43dac3c7
https://doi.org/10.2174/0929867023370031
https://doi.org/10.2174/0929867023370031
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 11:997-1000
Several alkenyl derivatives were prepared using allyl penam sulfone as the key intermediate. Isomers of these derivatives having beta configuration at C-6 showed potent activity against CcrA enzyme. A new method was developed to prepare propargyl pen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35389821de7bf45b6917dd779dd7561c
https://doi.org/10.1016/s0960-894x(01)00148-2
https://doi.org/10.1016/s0960-894x(01)00148-2