Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Amar J Azad"'
Autor:
Chris Denning, Andrew P Holmes, Katja Gehmlich, Nguyen T N Vo, Paulus Kirchhof, Jonas Euchner, Amar J Azad, Max J Cumberland
Publikováno v:
F1000Research, Vol 12 (2024)
Animal models have proven integral to broadening our understanding of complex cardiac diseases but have been hampered by significant species-dependent differences in cellular physiology. Human-induced pluripotent stem cell-derived cardiomyocytes (hiP
Externí odkaz:
https://doaj.org/article/5188b66493974968b86ab2bed156276c
Autor:
Chris Denning, Andrew P Holmes, Katja Gehmlich, Nguyen T N Vo, Paulus Kirchhof, Jonas Euchner, Amar J Azad, Max J Cumberland
Publikováno v:
F1000Research, Vol 12 (2023)
Animal models have proven integral to broadening our understanding of complex cardiac diseases but have been hampered by significant species-dependent differences in cellular physiology. Human-induced pluripotent stem cell-derived cardiomyocytes (hiP
Externí odkaz:
https://doaj.org/article/b68b92aa18c34d3196d8b3400e33af08
Autor:
Amar J. Azad, He Jiang, Charlotte Hooper, Sophie Broadway-Stringer, Violetta Steeples, Benjamin Davies, Hugh Watkins, Katja Gehmlich
Publikováno v:
Journal of Molecular and Cellular Cardiology. 173:16
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::72a3a8b74065b303e80932eeb45b9cb7
https://doi.org/10.1016/j.yjmcc.2022.08.033
https://doi.org/10.1016/j.yjmcc.2022.08.033
Publikováno v:
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 22, Iss 3058, p 3058 (2021)
International Journal of Molecular Sciences, Vol 22, Iss 3058, p 3058 (2021)
The Z-disc acts as a protein-rich structure to tether thin filament in the contractile units, the sarcomeres, of striated muscle cells. Proteins found in the Z-disc are integral for maintaining the architecture of the sarcomere. They also enable it t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f40ee23bcaf1c311f9438eb36d93cb38
https://ora.ox.ac.uk/objects/uuid:4ab75e80-0455-49b3-814a-19c0705e76ab
https://ora.ox.ac.uk/objects/uuid:4ab75e80-0455-49b3-814a-19c0705e76ab
Autor:
Julia Beglov, Henrik Isackson, Elisabeth Ehler, Jacinta I. Kalisch-Smith, Violetta Steeples, Duncan B. Sparrow, Katja Gehmlich, Pauline M. Bennett, Norbert Huebner, Charlotte Hooper, Raphael Heilig, Giannino Patone, Benjamin Davies, Hugh Watkins, Amar J. Azad, He Jiang, Mehroz Ehsan, Lisa Leinhos, Jillian N. Simon, Roman Fischer, Matthew Kelly
Publikováno v:
Basic Research in Cardiology
Titin truncating variants are a well-established cause of cardiomyopathy; however, the role of titin missense variants is less well understood. Here we describe the generation of a mouse model to investigate the underlying disease mechanism of a prev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd9bae3d34d47f484f0c6895019203df
https://doi.org/10.1007/s00395-021-00853-z
https://doi.org/10.1007/s00395-021-00853-z
Publikováno v:
Journal of Muscle Research and Cell Motility
Titin, the largest protein known, has attracted a lot of interest in the cardiovascular field in recent years, since the discovery that truncating variants in titin are commonly found in patients with dilated cardiomyopathy. This review will discuss
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::542e5df3936024d9f57937273dc8d6db
http://ora.ox.ac.uk/objects/uuid:
http://ora.ox.ac.uk/objects/uuid:
Autor:
Sophie Broadway-Stringer, He Jiang, Kirsty Wadmore, Charlotte Hooper, Gillian Douglas, Violetta Steeples, Amar J. Azad, Evie Singer, Jasmeet S. Reyat, Frantisek Galatik, Elisabeth Ehler, Pauline Bennett, Jacinta I. Kalisch-Smith, Duncan B. Sparrow, Benjamin Davies, Kristina Djinovic-Carugo, Mathias Gautel, Hugh Watkins, Katja Gehmlich
Publikováno v:
Cells, Vol 12, Iss 5, p 721 (2023)
Pathogenic variants in ACTN2, coding for alpha-actinin 2, are known to be rare causes of Hypertrophic Cardiomyopathy. However, little is known about the underlying disease mechanisms. Adult heterozygous mice carrying the Actn2 p.Met228Thr variant wer
Externí odkaz:
https://doaj.org/article/0ba42ffd89aa445d9501041c0b0f406d