Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Amar Bir Singh Sidhu"'
Autor:
Juan Carlos Valderramos, Brie Falkard, Celeste D. Li, Mark J. Siedner, Guy A. Schiehser, David A. Fidock, Photini Sinnis, Brendan J Kelly, Pedro A. Moura, Viswanathan Lakshmanan, Arba L. Ager, James C. Sacchettini, Catherine Vilchèze, Min Yu, William R. Jacobs, Chris J. Janse, Joel S. Freundlich, David P. Jacobus, Andrew P. Waters, Lisa A. Purcell, Alida Coppi, Jennifer H.C. Tsai, Volker Heussler, Laurent Kremer, Louis J. Nkrumah, T. R. Santha Kumar, Paul Gratraud, Amar Bir Singh Sidhu, Silke Retzlaff
Publikováno v:
Cell Host and Microbe
Cell Host and Microbe, Elsevier, 2008, 4 (6), pp.567-78. ⟨10.1016/j.chom.2008.11.001⟩
Cell Host and Microbe, Elsevier, 2008, 4 (6), pp.567-78. ⟨10.1016/j.chom.2008.11.001⟩
International audience; The fatty acid synthesis type II pathway has received considerable interest as a candidate therapeutic target in Plasmodium falciparum asexual blood-stage infections. This apicoplast-resident pathway, distinct from the mammali
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::746a1c500f373f1b157af12563485617
https://doi.org/10.1016/j.chom.2008.11.001
https://doi.org/10.1016/j.chom.2008.11.001
Autor:
John G. Logan, Ana Afonso, Iain W. McNae, Sandra Cheesman, Virgílio E. do Rosário, Pedro Cravo, Amar Bir Singh Sidhu, Stephanie G. Valderramos, Alison M. Creasey, Richard Carter, Paul Hunt, David A. Fidock, Richard Culleton
Publikováno v:
Molecular Microbiology
Artemisinin- and artesunate-resistant Plasmodium chabaudi mutants, AS-ART and AS-ATN, were previously selected from chloroquine-resistant clones AS-30CQ and AS-15CQ respectively. Now, a genetic cross between AS-ART and the artemisinin-sensitive clone
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35d5d4e3fac9e3a82f46883aa9e6e3b5
https://doi.org/10.1111/j.1365-2958.2007.05753.x
https://doi.org/10.1111/j.1365-2958.2007.05753.x
Autor:
Amar Bir Singh Sidhu, Louis J. Nkrumah, Michael W. Dunne, Qingan Sun, James C. Sacchettini, David A. Fidock
Publikováno v:
Journal of Biological Chemistry. 282:2494-2504
Azithromycin (AZ), a broad-spectrum antibacterial macrolide that inhibits protein synthesis, also manifests reasonable efficacy as an antimalarial. Its mode of action against malarial parasites, however, has remained undefined. Our in vitro investiga
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2f8f98ea2e10922a0f8ed28c90e59fb
https://doi.org/10.1074/jbc.m608615200
https://doi.org/10.1074/jbc.m608615200
Autor:
Juan Carlos Valderramos, Amar Bir Singh Sidhu, David A. Fidock, Sanjeev Krishna, Anne-Catrin Uhlemann, Stephanie G. Valderramos
Publikováno v:
The Journal of Infectious Diseases. 194:528-535
The global dissemination of drug-resistant Plasmodium falciparum is spurring intense efforts to implement artemisinin (ART)-based combination therapies for malaria, including mefloquine (MFQ)-artesunate and lumefantrine (LUM)-artemether. Clinical stu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfcd31d9792b82c69171554fa1406c26
https://doi.org/10.1086/507115
https://doi.org/10.1086/507115
Autor:
Donald J. Krogstad, Viswanathan Lakshmanan, David A. Fidock, Patrick G. Bray, Dominik Verdier-Pinard, Ruth H Hughes, George E Alakpa, Paul Horrocks, Steve A. Ward, Rebecca A. Muhle, Amar Bir Singh Sidhu, David J. Johnson
Publikováno v:
The EMBO Journal. 24:2294-2305
Chloroquine resistance (CQR) in Plasmodium falciparum is associated with mutations in the digestive vacuole transmembrane protein PfCRT. However, the contribution of individual pfcrt mutations has not been clarified and other genes have been postulat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97fe699259d547f68476f652889a9b59
https://doi.org/10.1038/sj.emboj.7600681
https://doi.org/10.1038/sj.emboj.7600681
Autor:
Patrick G. Bray, David A. Fidock, David J. Johnson, Amar Bir Singh Sidhu, Mathirut Mungthin, Stephen A. Ward, Viswanathan Lakshmanan
Publikováno v:
Molecular Cell. 15:867-877
Chloroquine resistance in Plasmodium falciparum is primarily conferred by mutations in pfcrt. Parasites resistant to chloroquine can display hypersensitivity to other antimalarials; however, the patterns of cross-resistance are complex, and the genet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f94bef84879e747e647d5c7357a36a5
https://doi.org/10.1016/j.molcel.2004.09.012
https://doi.org/10.1016/j.molcel.2004.09.012
Publikováno v:
Science. 298:210-213
Plasmodium falciparum chloroquine resistance is a major cause of worldwide increases in malaria mortality and morbidity. Recent laboratory and clinical studies have associated chloroquine resistance with point mutations in the gene pfcrt . However, d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::131f635d0381c3aa72febc363361270a
https://doi.org/10.1126/science.1074045
https://doi.org/10.1126/science.1074045
Autor:
Amar Bir Singh Sidhu, Robert Bittman, Remo Perozzo, Mack Kuo, Jacob T. Valiyaveettil, David A. Fidock, James C. Sacchettini, William R. Jacobs
Publikováno v:
Journal of Biological Chemistry. 277:13106-13114
The human malaria parasite Plasmodium falciparum synthesizes fatty acids using a type II pathway that is absent in humans. The final step in fatty acid elongation is catalyzed by enoyl acyl carrier protein reductase, a validated antimicrobial drug ta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f62b2e4e970201f911d2da74677f0bb
https://doi.org/10.1074/jbc.m112000200
https://doi.org/10.1074/jbc.m112000200
Autor:
Regina Joice, Jacqui Montgomery, Matthias Marti, Dyann F. Wirth, Daouda Ndiaye, Willythssa Pierre-Louis, Danny A. Milner, Curtis Huttenhower, Keunyoung Oh, Kim C. Williamson, Johanna P. Daily, Terrie E. Taylor, Roger C. Wiegand, Amar Bir Singh Sidhu, Karl B. Seydel, Vagheesh M. Narasimhan, Evan C. Meyer
Publikováno v:
PLoS Computational Biology
PLoS Computational Biology, Vol 9, Iss 12, p e1003392 (2013)
PLoS Computational Biology, Vol 9, Iss 12, p e1003392 (2013)
In the current era of malaria eradication, reducing transmission is critical. Assessment of transmissibility requires tools that can accurately identify the various developmental stages of the malaria parasite, particularly those required for transmi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49c36c8ecea889ca143ceab2d01c83b2
http://europepmc.org/articles/PMC3861035
http://europepmc.org/articles/PMC3861035
Autor:
Amar Bir Singh Sidhu, Bronwen Naudé, Kirk W. Deitsch, Angela K. Talley, Takashi Nomura, Roland A. Cooper, Sergey M. Dzekunov, Lyann M. B. Ursos, David A. Fidock, John C. Wootton, Paul D. Roepe, Thomas E. Wellems, Xin-zhuan Su, Michael T. Ferdig
Publikováno v:
Molecular Cell. 6:861-871
The determinant of verapamil-reversible chloroquine resistance (CQR) in a Plasmodium falciparum genetic cross maps to a 36 kb segment of chromosome 7. This segment harbors a 13-exon gene, pfcrt, having point mutations that associate completely with C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0068647106f873f7c31a86e5da9af8ed
https://doi.org/10.1016/s1097-2765(05)00077-8
https://doi.org/10.1016/s1097-2765(05)00077-8