Zobrazeno 1 - 10
of 195
pro vyhledávání: '"Amar B. Singh"'
Publikováno v:
BioMedInformatics, Vol 4, Iss 3, Pp 1822-1834 (2024)
Background: Improved technologies for chromatin accessibility sequencing such as ATAC-seq have increased our understanding of gene regulation mechanisms, particularly in disease conditions such as cancer. Methods: This study introduces a computationa
Externí odkaz:
https://doaj.org/article/7d88edf90f47413baa49811187c629b3
Autor:
Chaitanya K. Valiveti, Balawant Kumar, Anuj D. Singh, Sham K. Biradar, Rizwan Ahmad, Amar B. Singh, Hemachand Tummala
Publikováno v:
Cells, Vol 13, Iss 11, p 957 (2024)
Inflammatory bowel disease (IBD) is a chronic gut disorder that also elevates the risk of colorectal cancer (CRC). The global incidence and severity of IBD are rising, yet existing therapies often lead to severe side effects. Curcumin offers potent a
Externí odkaz:
https://doaj.org/article/8a43f01e2bf14a9094eb7b1936e1f7f2
Autor:
Rizwan Ahmad, Balawant Kumar, Raju Lama Tamang, Geoffrey A. Talmon, Punita Dhawan, Amar B. Singh
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-15 (2023)
Abstract Impaired autophagy promotes Inflammatory Bowel Disease (IBD). Claudin-2 is upregulated in IBD however its role in the pathobiology remains uncertain due to its complex regulation, including by autophagy. Irrespective, claudin-2 expression pr
Externí odkaz:
https://doaj.org/article/6a56b71ff05b40b3a04d197b02b4e253
Autor:
Rizwan Ahmad, Balawant Kumar, Ishwor Thapa, Geoffrey A. Talmon, Jeffrey Salomon, Amanda E. Ramer-Tait, Dhundy K. Bastola, Punita Dhawan, Amar B. Singh
Publikováno v:
Gut Microbes, Vol 15, Iss 2 (2023)
ABSTRACTDysregulation of both the gut barrier and microbiota (dysbiosis) promotes susceptibility to and severity of Inflammatory Bowel Diseases (IBD). Leaky gut and dysbiosis often coexist; however, potential interdependence and molecular regulation
Externí odkaz:
https://doaj.org/article/16660186e92e4850a9ee086696636cc2
Autor:
Jeffrey D. Salomon, Haowen Qiu, Dan Feng, Jacob Owens, Ludmila Khailova, Suzanne Osorio Lujan, John Iguidbashian, Yashpal S. Chhonker, Daryl J. Murry, Jean-Jack Riethoven, Merry L. Lindsey, Amar B. Singh, Jesse A. Davidson
Publikováno v:
Disease Models & Mechanisms, Vol 16, Iss 5 (2023)
Externí odkaz:
https://doaj.org/article/87fb0a1681ff47a0a07e9a1df95f28a7
Autor:
Iram Fatima, Jaya Prakash Uppada, Yashpal S. Chhonker, Saiprasad Gowrikumar, Susmita Barman, Sourav Roy, Kirsten T. Tolentino, Nicholas Palermo, Amar Natarajan, Daniel R. Beauchamp, Alex Vecchio, Daryl J. Murry, Amar B. Singh, Corey R. Hopkins, Punita Dhawan
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 159, Iss , Pp 114255- (2023)
Colorectal cancer (CRC) is a leading cause of the cancer-related deaths worldwide. Thus, developing novel and targeted therapies for inhibiting CRC progression and metastasis is urgent. Several studies, including ours, have reported a causal role for
Externí odkaz:
https://doaj.org/article/9b12370eb6d241ba856c9504df44b76e
Autor:
Raju Lama Tamang, Balawant Kumar, Sagar M. Patel, Ishwor Thapa, Alshomrani Ahmad, Vikas Kumar, Rizwan Ahmad, Donald F. Becker, Dundy (Kiran) Bastola, Punita Dhawan, Amar B. Singh
Publikováno v:
Cells, Vol 12, Iss 14, p 1883 (2023)
Background: Despite significant progress in clinical management, colorectal cancer (CRC) remains the third most common cause of cancer-related deaths. A positive association between PYCR2 (pyrroline-5-carboxylate reductase-2), a terminal enzyme of pr
Externí odkaz:
https://doaj.org/article/78a36d7ab7404622b9af9990cab0c189
Autor:
Balawant Kumar, Rizwan Ahmad, Giovanna A. Giannico, Roy Zent, Geoffrey A. Talmon, Raymond C. Harris, Peter E. Clark, Vinata Lokeshwar, Punita Dhawan, Amar B. Singh
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 40, Iss 1, Pp 1-16 (2021)
Abstract Background Claudin-2 expression is upregulated in multiple cancers and promotes cancer malignancy. Remarkably, the regulation of claudin-2 expression in kidney cell lines contrasts its reported regulation in other organs. However, claudin-2
Externí odkaz:
https://doaj.org/article/ca0bad1ca624408989451271e8064bf3
Publikováno v:
Cancer Medicine, Vol 9, Iss 17, Pp 6322-6329 (2020)
Abstract Targeting mitotic kinases is an emerging anticancer approach with promising preclinical outcomes. Microtubule‐associated serine/threonine kinase like (MASTL), also known as Greatwall (Gwl), is an important mitotic kinase that regulates mit
Externí odkaz:
https://doaj.org/article/85b651db6edd4f26b300b86e7ab6e69a
Autor:
Amber N. Johnson, Jack R. Harkema, Amy J. Nelson, John D. Dickinson, Julianna Kalil, Michael J. Duryee, Geoffrey M. Thiele, Balawant Kumar, Amar B. Singh, Rohit Gaurav, Sarah C. Glover, Ying Tang, Debra J. Romberger, Tammy Kielian, Jill A. Poole
Publikováno v:
Respiratory Research, Vol 21, Iss 1, Pp 1-14 (2020)
Abstract Background Environmental organic dust exposures enriched in Toll-like receptor (TLR) agonists can reduce allergic asthma development but are associated with occupational asthma and chronic bronchitis. The TLR adaptor protein myeloid differen
Externí odkaz:
https://doaj.org/article/37b379af598644059ffd603bf05e2d0d