Zobrazeno 1 - 10
of 196
pro vyhledávání: '"Amar B Singh"'
Autor:
Rizwan Ahmad, Balawant Kumar, Raju Lama Tamang, Wei Xu, Geoffrey A Talmon, Aaron M Mohs, Punita Dhawan, Amar B Singh
Publikováno v:
BioTechniques, Vol 71, Iss 3, Pp 456-464 (2021)
The conventional orthotopic/xenograft models or genetically engineered murine models of colon cancer (CRC) are limited in their scope for a true understanding of tumor growth, progression and eventual metastasis in its natural microenvironment. In th
Externí odkaz:
https://doaj.org/article/dd1e8d1f14d347cf9e200a59f4d68cb2
Autor:
Ajaz A Bhat, Ashok Sharma, Jillian Pope, Moorthy Krishnan, Mary K Washington, Amar B Singh, Punita Dhawan
Publikováno v:
PLoS ONE, Vol 7, Iss 6, p e37174 (2012)
Dysregulation of tight junctions (TJs) is often associated with human diseases including carcinogenesis and recent studies support role of TJ integral proteins in the regulation of Epithelial-to-Mesenchymal Transition (EMT). In this regard, expressio
Externí odkaz:
https://doaj.org/article/828f722e3cb94e69a5e5daf9d9c2f52e
Autor:
Rizwan Ahmad, Balawant Kumar, Raju Lama Tamang, Geoffrey A. Talmon, Punita Dhawan, Amar B. Singh
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-15 (2023)
Abstract Impaired autophagy promotes Inflammatory Bowel Disease (IBD). Claudin-2 is upregulated in IBD however its role in the pathobiology remains uncertain due to its complex regulation, including by autophagy. Irrespective, claudin-2 expression pr
Externí odkaz:
https://doaj.org/article/6a56b71ff05b40b3a04d197b02b4e253
Autor:
Rizwan Ahmad, Balawant Kumar, Ishwor Thapa, Geoffrey A. Talmon, Jeffrey Salomon, Amanda E. Ramer-Tait, Dhundy K. Bastola, Punita Dhawan, Amar B. Singh
Publikováno v:
Gut Microbes, Vol 15, Iss 2 (2023)
ABSTRACTDysregulation of both the gut barrier and microbiota (dysbiosis) promotes susceptibility to and severity of Inflammatory Bowel Diseases (IBD). Leaky gut and dysbiosis often coexist; however, potential interdependence and molecular regulation
Externí odkaz:
https://doaj.org/article/16660186e92e4850a9ee086696636cc2
Autor:
Jeffrey D. Salomon, Haowen Qiu, Dan Feng, Jacob Owens, Ludmila Khailova, Suzanne Osorio Lujan, John Iguidbashian, Yashpal S. Chhonker, Daryl J. Murry, Jean-Jack Riethoven, Merry L. Lindsey, Amar B. Singh, Jesse A. Davidson
Publikováno v:
Disease Models & Mechanisms, Vol 16, Iss 5 (2023)
Externí odkaz:
https://doaj.org/article/87fb0a1681ff47a0a07e9a1df95f28a7
Autor:
Iram Fatima, Jaya Prakash Uppada, Yashpal S. Chhonker, Saiprasad Gowrikumar, Susmita Barman, Sourav Roy, Kirsten T. Tolentino, Nicholas Palermo, Amar Natarajan, Daniel R. Beauchamp, Alex Vecchio, Daryl J. Murry, Amar B. Singh, Corey R. Hopkins, Punita Dhawan
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 159, Iss , Pp 114255- (2023)
Colorectal cancer (CRC) is a leading cause of the cancer-related deaths worldwide. Thus, developing novel and targeted therapies for inhibiting CRC progression and metastasis is urgent. Several studies, including ours, have reported a causal role for
Externí odkaz:
https://doaj.org/article/9b12370eb6d241ba856c9504df44b76e
Autor:
Raju Lama Tamang, Balawant Kumar, Sagar M. Patel, Ishwor Thapa, Alshomrani Ahmad, Vikas Kumar, Rizwan Ahmad, Donald F. Becker, Dundy (Kiran) Bastola, Punita Dhawan, Amar B. Singh
Publikováno v:
Cells, Vol 12, Iss 14, p 1883 (2023)
Background: Despite significant progress in clinical management, colorectal cancer (CRC) remains the third most common cause of cancer-related deaths. A positive association between PYCR2 (pyrroline-5-carboxylate reductase-2), a terminal enzyme of pr
Externí odkaz:
https://doaj.org/article/78a36d7ab7404622b9af9990cab0c189
Autor:
Balawant Kumar, Rizwan Ahmad, Giovanna A. Giannico, Roy Zent, Geoffrey A. Talmon, Raymond C. Harris, Peter E. Clark, Vinata Lokeshwar, Punita Dhawan, Amar B. Singh
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 40, Iss 1, Pp 1-16 (2021)
Abstract Background Claudin-2 expression is upregulated in multiple cancers and promotes cancer malignancy. Remarkably, the regulation of claudin-2 expression in kidney cell lines contrasts its reported regulation in other organs. However, claudin-2
Externí odkaz:
https://doaj.org/article/ca0bad1ca624408989451271e8064bf3
Autor:
Megan Lynn Otte, Raju Lama Tamang, Julia Papapanagiotou, Rizwan Ahmad, Punita Dhawan, Amar B Singh
Publikováno v:
World Journal of Gastroenterology. 29:1157-1172
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::02ef2f0543ebf0f314bdfd55e68b969d
https://doi.org/10.3748/wjg.v29.i7.1157
https://doi.org/10.3748/wjg.v29.i7.1157
Autor:
Jagadesan Sankarasubramanian, Rizwan Ahmad, Nagavardhini Avuthu, Amar B. Singh, Chittibabu Guda
Publikováno v:
Frontiers in Medicine, Vol 7 (2020)
Background: Inflammatory bowel disease (IBD) represents multifactorial chronic inflammatory conditions in the gastrointestinal tract and includes Crohn's disease (CD) and ulcerative colitis (UC). Despite similarities in pathobiology and disease sympt
Externí odkaz:
https://doaj.org/article/a00e8db6f5e9407a9f25e54f89e30755