Differential transcript usage unravels gene expression alterations in Alzheimer’s disease human brains

Autor: Diego Marques-Coelho, Lukas da Cruz Carvalho Iohan, Ana Raquel Melo de Farias, Amandine Flaig, The Brainbank Neuro–CEB Neuropathology Network, Jean-Charles Lambert, Marcos Romualdo Costa

Publikováno v: npj Aging and Mechanisms of Disease, Vol 7, Iss 1, Pp 1-15 (2021)

Abstract Alzheimer’s disease (AD) is the leading cause of dementia in aging individuals. Yet, the pathophysiological processes involved in AD onset and progression are still poorly understood. Among numerous strategies, a comprehensive overview of

Externí odkaz: https://doaj.org/article/d9b5cd0c8e78499db37977012745cbe4

Differential transcript usage unravels gene expression alterations in Alzheimer’s disease human brains

Autor: Ana Raquel Melo de Farias, Lukas da Cruz Carvalho Iohan, Diego Marques-Coelho, Marcos R. Costa, Jean-Charles Lambert, Amandine Flaig

Publikováno v: Repositório Institucional da UFRN
Universidade Federal do Rio Grande do Norte (UFRN)
instacron:UFRN
npj Aging and Mechanisms of Disease, Vol 7, Iss 1, Pp 1-15 (2021)
npj Aging and Mechanisms of Disease
npj Aging and Mechanisms of Disease, 2021, 7 (1), pp.2. ⟨10.1038/s41514-020-00052-5⟩
NPJ Aging and Mechanisms of Disease

Alzheimer’s disease (AD) is the leading cause of dementia in aging individuals. Yet, the pathophysiological processes involved in AD onset and progression are still poorly understood. Among numerous strategies, a comprehensive overview of gene expr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5441d4d1cdd496ab566269079db9d009
https://repositorio.ufrn.br/handle/123456789/31194

Identification of a functional FADS1 3′UTR variant associated with erythrocyte n-6 polyunsaturated fatty acids levels

Autor: Xavier Hermant, Amandine Flaig, Dominique Cottel, Gilbert Briand, Brigitte Laillet, Chantal Simon, Aline Meirhaeghe, Marie-Adélaïde Bout, Julie Dumont, Dominique Arveiler, Aline Wagner, Jean Dallongeville, Charlotte Delay, Jean-Bernard Ruidavets, Jimena Luque-Bedregal, Jean Ferrières, Philippe Amouyel

Publikováno v: Journal of clinical lipidology
Journal of clinical lipidology, Elsevier, 2018, 12 (5), pp.1280--1289. ⟨10.1016/j.jacl.2018.07.012⟩
Journal of clinical lipidology, 2018, 12 (5), pp.1280--1289. ⟨10.1016/j.jacl.2018.07.012⟩

International audience; BACKGROUND: Blood polyunsaturated fatty acid (PUFA) levels are determined by diet and by endogenous synthesis via Delta 5- and Delta 6-desaturases (encoded by the FADS] and FADS2 genes, respectively). Genome-wide association s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::776b9882168384015577c4c64face99e
https://doi.org/10.1016/j.jacl.2018.07.012

Correction to: Alzheimer’s genetic risk factor FERMT2 (Kindlin-2) controls axonal growth and synaptic plasticity in an APP-dependent manner

Autor: Sébastien S. Hébert, Mélissa Farinelli, Emmanuelle Boscher, Jean-Charles Lambert, Charlotte Bauer, Xavier Hanoulle, Florie Demiautte, Fanny Eysert, Sandrine Hughes, Ian Pike, Benjamin Grenier-Boley, Audrey Coulon, Philippe Amouyel, Mikael Marttinen, Anaїs-Camille Vreulx, Mari Takalo, Amandine Flaig, Frédéric Checler, Julie Dumont, Devrim Kilinc, Julien Chapuis, Tiago Mendes, Nicolas Malmanche, Mikko Hiltunen, Shruti Desai, Charlotte Delay

Publikováno v: Molecular Psychiatry. 26:5608-5608

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7244fc1e208dbc5c1d1c06daaec3e017
https://doi.org/10.1038/s41380-020-01015-8

ADAM30 Downregulates APP-Linked Defects Through Cathepsin D Activation in Alzheimer's Disease

Autor: Pierre Dourlen, Yves Lemoine, Amandine Flaig, Frédéric Checler, Anne Marie Ayral, Jean-Charles Lambert, Kris Gevaert, Mathias Laga, Fanny Eysert, Tiago Mendes, David M. A. Mann, Linda Chami, Anne Sophie Hérard, Thierry Delzescaux, Franck Lafont, Florie Demiautte, Franck Hansmannel, Benoit Deprez, Charlotte Delay, David Hot, Florence Leroux, Bart Dermaut, Philippe Amouyel, Ludovic Huot, Yoann Sottejeau, Florence Pasquier, Nicolas Souedet, Florent Letronne, Charlotte Bauer, Marc Dhenain, Marie Lesaffre, Geoffroy Laumet, Nicolas Malmanche, David Tulasne, Claudine Berr, Rebecca Deprez, Julie Dumont, Elisabeth Werkmeister, Michel E. Vandenberghe, Jean Jacques Hauw, Julien Chapuis

Publikováno v: EBioMedicine
EBioMedicine, 2016, 9, pp.278-292. ⟨10.1016/j.ebiom.2016.06.002⟩
Letronne, F, Laumet, G, Ayral, A-M, Chapuis, J, Demiautte, F, Laga, M, Vandenberghe, M, Malmanche, N, Leroux, F, Eysert, F, Sottejeau, Y, Chami, L, Flaig, A, Bauer, C, Dourlen, P, Lesaffre, M, Delay, C, Huot, L, Dumont, J, Werkmeister, E, Lafont, F, Mendes, T, Hansmannel, F, Dermaut, B, Deprez, B, Hérard, A-S, Dhenain, M, Souedet, N, Pasquier, F, Tulasne, D, Berr, C, Hauw, J-J, Lemoine, Y, Amouyel, P, Mann, D, Déprez, R, Checler, F, Hot, D, Delzescaux, T, Gevaert, K & Lambert, J-C 2016, ' ADAM30 Downregulates APP-Linked Defects Through Cathepsin D Activation in Alzheimer's Disease ', EBioMedicine . https://doi.org/10.1016/j.ebiom.2016.06.002
EBioMedicine, Elsevier, 2016, 9, pp.278-292. ⟨10.1016/j.ebiom.2016.06.002⟩
EBioMedicine, Vol 9, Iss C, Pp 278-292 (2016)
EBIOMEDICINE

Although several ADAMs (A disintegrin-like and metalloproteases) have been shown to contribute to the amyloid precursor protein (APP) metabolism, the full spectrum of metalloproteases involved in this metabolism remains to be established. Transcripto

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a9bf8d295c4426a333c53668484f520
https://pubmed.ncbi.nlm.nih.gov/27333034