Zobrazeno 1 - 10
of 150
pro vyhledávání: '"Amander T, Clark"'
Autor:
Sajedeh Nasr Esfahani, Yi Zheng, Auriana Arabpour, Agnes M. Resto Irizarry, Norio Kobayashi, Xufeng Xue, Yue Shao, Cheng Zhao, Nicole L. Agranonik, Megan Sparrow, Timothy J. Hunt, Jared Faith, Mary Jasmine Lara, Qiu Ya Wu, Sherman Silber, Sophie Petropoulos, Ran Yang, Kenneth R. Chien, Amander T. Clark, Jianping Fu
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract Primordial germ cells (PGCs) are the embryonic precursors of sperm and eggs. They transmit genetic and epigenetic information across generations. Given the prominent role of germline defects in diseases such as infertility, detailed understa
Externí odkaz:
https://doaj.org/article/02b01149bd9a4d4b90ae32c178d7a07f
Autor:
Roxane Verdikt, Abigail A Armstrong, Jenny Cheng, Young Sun Hwang, Amander T Clark, Xia Yang, Patrick Allard
Publikováno v:
eLife, Vol 12 (2023)
Cannabis, the most consumed illicit psychoactive drug in the world, is increasingly used by pregnant women. However, while cannabinoid receptors are expressed in the early embryo, the impact of phytocannabinoids exposure on early embryonic processes
Externí odkaz:
https://doaj.org/article/74ecd0a984034e34a84c883a1574471e
Autor:
Mary Jasmine D. Lara, Sissy E. Wamaitha, Auriana Arabpour, Jon D. Hennebold, Amander T. Clark, Enrique Sosa
Publikováno v:
Stem Cell Research, Vol 73, Iss , Pp 103241- (2023)
We generated and characterized a rhesus macaque induced pluripotent stem cell (iPSC) line using induced reprogramming of fibroblasts isolated from a rhesus macaque fetus. The fibroblasts were expanded and then reprogrammed using non-integrating Senda
Externí odkaz:
https://doaj.org/article/a400b64c09034879912a73ba4600bf51
Publikováno v:
iScience, Vol 26, Iss 7, Pp 107191- (2023)
Summary: Ten Eleven Translocation 1 (TET1) is a regulator of localized DNA demethylation through the conversion of 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC). To examine DNA demethylation in human primordial germ cell-like cells (hPGCLC
Externí odkaz:
https://doaj.org/article/91098bd35c164283bb1b4cbdd6401d70
Autor:
Xinyu Xiang, Yu Tao, Jonathan DiRusso, Fei-Man Hsu, Jinchun Zhang, Ziwei Xue, Julien Pontis, Didier Trono, Wanlu Liu, Amander T. Clark
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
The transcription factor network required for primordial germ cell (PGC) specification is known to diverge in mammals. Here the authors show that hominidae-specific transposable element (TE) LTR5Hs becomes transcriptionally active during PGC specific
Externí odkaz:
https://doaj.org/article/355e9c274ddd4b0e8684e5949c16e842
Autor:
Varsha P. Desai, Jihed Chouaref, Haoyu Wu, William A. Pastor, Ryan L. Kan, Harald M. Oey, Zheng Li, Jamie Ho, Kelly K. D. Vonk, David San Leon Granado, Michael A. Christopher, Amander T. Clark, Steven E. Jacobsen, Lucia Daxinger
Publikováno v:
Epigenetics & Chromatin, Vol 14, Iss 1, Pp 1-14 (2021)
Abstract Background Microrchidia proteins (MORCs) are involved in epigenetic gene silencing in a variety of eukaryotic organisms. Deletion of MORCs result in several developmental abnormalities and their dysregulation has been implicated in developme
Externí odkaz:
https://doaj.org/article/6a9ba9b297874f7ca3dba29dbcb2f709
Autor:
Joanna J. Gell, Wanlu Liu, Enrique Sosa, Alex Chialastri, Grace Hancock, Yu Tao, Sissy E. Wamaitha, Grace Bower, Siddharth S. Dey, Amander T. Clark
Publikováno v:
Stem Cell Reports, Vol 14, Iss 3, Pp 433-446 (2020)
Summary: The development of an in vitro system in which human primordial germ cell-like cells (hPGCLCs) are generated from human pluripotent stem cells (hPSCs) has been invaluable to further our understanding of human primordial germ cell (hPGC) spec
Externí odkaz:
https://doaj.org/article/1d258719278f4bf0b2a02308b0f8ac24
Autor:
Erica C. Pandolfi, Timothy J. Hunt, Sierra Goldsmith, Kellie Hurlbut, Sherman J. Silber, Amander T. Clark
Publikováno v:
Stem Cell Research, Vol 54, Iss , Pp 102409- (2021)
We generated three human induced pluripotent stem cell (hiPSC) sublines from human dermal fibroblasts (HDF) (MZT05) generated from a skin biopsy donated from a previously fertile woman. The skin biopsy was broadly consented for generating hiPSC lines
Externí odkaz:
https://doaj.org/article/977e1c71a6a94390aaeae5ff70535620
Autor:
Erica C. Pandolfi, Enrique Sosa, Timothy J. Hunt, Sierra Goldsmith, Kellie Hurlbut, Sherman J. Silber, Amander T. Clark
Publikováno v:
Stem Cell Research, Vol 51, Iss , Pp 102204- (2021)
Six human induced pluripotent stem cell sublines (hiPSCs) were generated from human dermal fibroblasts (HDFs) derived from skin biopsies donated from monozygotic twin women wherein one woman had proven fertility and her sister was infertile due to ov
Externí odkaz:
https://doaj.org/article/021ab66534e4464190823cc6fcc6d152
Autor:
Enrique Sosa, Di Chen, Ernesto J. Rojas, Jon D. Hennebold, Karen A. Peters, Zhuang Wu, Truong N. Lam, Jennifer M. Mitchell, Meena Sukhwani, Ramesh C. Tailor, Marvin L. Meistrich, Kyle E. Orwig, Gunapala Shetty, Amander T. Clark
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Human embryonic stem cells can be differentiated in vitro into primordial germ cell-like cells (PGCLCs) that resemble early primordial germ cells (PGCs). Here the authors transplant PGCLCs generated from rhesus macaque iPSCs into mouse and rhesus mac
Externí odkaz:
https://doaj.org/article/364bc6a1087149ce821ef0255a15a53c