Cytolethal distending toxins require components of the ER-associated degradation pathway for host cell entry.

Autor: Aria Eshraghi, Shandee D Dixon, Batcha Tamilselvam, Emily Jin-Kyung Kim, Amandeep Gargi, Julia C Kulik, Robert Damoiseaux, Steven R Blanke, Kenneth A Bradley

Publikováno v: PLoS Pathogens, Vol 10, Iss 7, p e1004295 (2014)

Intracellular acting protein exotoxins produced by bacteria and plants are important molecular determinants that drive numerous human diseases. A subset of these toxins, the cytolethal distending toxins (CDTs), are encoded by several Gram-negative pa

Externí odkaz: https://doaj.org/article/a76b6d0d62d947d3a016494823d46b54

Cytolethal Distending Toxin Family Members Are Differentially Affected by Alterations in Host Glycans and Membrane Cholesterol

Autor: Marissa M. Cardwell, Francisco J. Maldonado-Arocho, Michael G. Prouty, Kenneth A. Bradley, Amandeep Gargi, Steven R. Blanke, Aria Eshraghi

Publikováno v: Journal of Biological Chemistry. 285:18199-18207

Cytolethal distending toxins (CDTs) are tripartite protein exotoxins produced by a diverse group of pathogenic Gram-negative bacteria. Based on their ability to induce DNA damage, cell cycle arrest, and apoptosis of cultured cells, CDTs are proposed

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf0042a3dbbe0f8eef0cd4e0da3b6d96
https://doi.org/10.1074/jbc.m110.112912

Selective inhibitor of endosomal trafficking pathways exploited by multiple toxins and viruses

Autor: Eugene J. Gillespie, Chi-Lee C. Ho, Kavitha Balaji, Daniel L. Clemens, Gang Deng, Yao E. Wang, Heidi J. Elsaesser, Batcha Tamilselvam, Amandeep Gargi, Shandee D. Dixon, Bryan France, Brian T. Chamberlain, Steven R. Blanke, Genhong Cheng, Juan Carlos de la Torre, David G. Brooks, Michael E. Jung, John Colicelli, Robert Damoiseaux, Kenneth A. Bradley

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America, vol 110, iss 50
Gillespie, EJ; Ho, CLC; Balaji, K; Clemens, DL; Deng, G; Wang, YE; et al.(2013). Selective inhibitor of endosomal trafficking pathways exploited by multiple toxins and viruses. Proceedings of the National Academy of Sciences of the United States of America, 110(50). doi: 10.1073/pnas.1302334110. UCLA: Retrieved from: http://www.escholarship.org/uc/item/4vf3g2sj

Pathogenic microorganisms and toxins have evolved a variety of mechanisms to gain access to the host-cell cytosol and thereby exert virulent effects upon the host. One common mechanism of cellular entry requires trafficking to an acidified endosome,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a951ab6a01af6d1009c6744f539fd12
https://escholarship.org/uc/item/4vf3g2sj

Differential regulation of map kinase isoforms by H2O2 in neuronal cells.

Autor: Amandeep Gargi, Naresh Kumar, Chinmoy S. Dey

Publikováno v: Neuroscience Research Communications; Jul/Aug2003, Vol. 33 Issue 1, p17, 13p