Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Amanda-Jayne F. Carr"'
Bestrophinopathies: perspectives on clinical disease, Bestrophin-1 function and developing therapies
Publikováno v:
Therapeutic Advances in Ophthalmology, Vol 13 (2021)
Bestrophinopathies are a group of clinically distinct inherited retinal dystrophies that typically affect the macular region, an area synonymous with central high acuity vision. This spectrum of disorders is caused by mutations in bestrophin1 ( BEST1
Externí odkaz:
https://doaj.org/article/cd99e6205e4e40669cf54e5108c9db90
Autor:
Katharina Lueck, Amanda-Jayne F. Carr, Dimitrios Stampoulis, Volker Gerke, Ursula Rescher, John Greenwood, Stephen E. Moss
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
Abstract The retinoic acid derivative fenretinide (FR) is capable of transdifferentiating cultured retinal pigment epithelial (RPE) cells towards a neuronal-like phenotype, but the underlying mechanisms are not understood. To identify genes involved
Externí odkaz:
https://doaj.org/article/51d55e5e3165498991da240361a0634b
Autor:
Conor M. Ramsden, Britta Nommiste, Amelia R. Lane, Amanda-Jayne F. Carr, Michael B. Powner, Matthew J. K. Smart, Li Li Chen, Manickam N. Muthiah, Andrew R. Webster, Anthony T. Moore, Michael E. Cheetham, Lyndon da Cruz, Peter J. Coffey
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
Abstract Inherited retinal dystrophies are an important cause of blindness, for which currently there are no effective treatments. In order to study this heterogeneous group of diseases, adequate disease models are required in order to better underst
Externí odkaz:
https://doaj.org/article/2c6bb3edda1a42e7b46f27b3e51b9e86
Autor:
Camille Yvon, Conor M. Ramsden, Amelia Lane, Michael B. Powner, Lyndon da Cruz, Peter J. Coffey, Amanda-Jayne F. Carr
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 13, Iss C, Pp 382-389 (2015)
Retinal degeneration arises from the loss of photoreceptors or retinal pigment epithelium (RPE). It is one of the leading causes of irreversible blindness worldwide with limited effective treatment options. Generation of induced pluripotent stem cell
Externí odkaz:
https://doaj.org/article/4848c3dce7664794b6915626e083733e
Autor:
Amy Leung, Almudena Sacristan-Reviriego, Pedro R.L. Perdigão, Hali Sai, Michalis Georgiou, Angelos Kalitzeos, Amanda-Jayne F. Carr, Peter J. Coffey, Michel Michaelides, James Bainbridge, Michael E. Cheetham, Jacqueline van der Spuy
Publikováno v:
Stem Cell Reports. 17:2187-2202
Leber congenital amaurosis type 4 (LCA4), caused by AIPL1 mutations, is characterized by severe sight impairment in infancy and rapidly progressing degeneration of photoreceptor cells. We generated retinal organoids using induced pluripotent stem cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd48dd7e79bd2b59428b7b1ce5139f43
https://doi.org/10.1016/j.stemcr.2022.08.005
https://doi.org/10.1016/j.stemcr.2022.08.005
Autor:
Amy Leung, Almudena Sacristan-Reviriego, Pedro R. L. Perdigão, Hali Sai, Michalis Georgiou, Angelos Kalitzeos, Amanda-Jayne F. Carr, Peter J. Coffey, Michel Michaelides, James Bainbridge, Michael E. Cheetham, Jacqueline van der Spuy
SummaryLeber Congenital Amaurosis type 4 (LCA4), caused by AIPL1 mutations, is characterised by severe sight impairment in infancy and rapidly progressive degeneration of photoreceptor cells. We generated retinal organoids using induced pluripotent s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b81792357e65ced4c9e93af4514cf9ee
https://doi.org/10.1101/2021.12.17.473147
https://doi.org/10.1101/2021.12.17.473147
Publikováno v:
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)
Scientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)
Wnt signalling mediates complex cell-cellinteractions during development and proliferation. Annexin A8 (AnxA8), a calcium-dependent phospholipid-binding protein, and canonical Wnt signalling mechanisms have both been implicated in retinal pigment epi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2562edd67c9cb3b18b2472b211485cb
https://doi.org/10.1038/s41598-020-58296-w
https://doi.org/10.1038/s41598-020-58296-w
Publikováno v:
Advances in experimental medicine and biology. 1185
Bestrophinopathies are a group of clinically distinct inherited retinal dystrophies that lead to the gradual loss of vision in and around the macular area. There are no treatments for patients suffering from bestrophinopathies, and no measures can be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f84a286e46f54f4ae29f1f85cffe40a2
https://pubmed.ncbi.nlm.nih.gov/31884648
https://pubmed.ncbi.nlm.nih.gov/31884648
Autor:
Amanda-Jayne F. Carr
Publikováno v:
Acta Ophthalmologica. 97
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f922c263a0ad3f96f76b9234418a2f39
https://doi.org/10.1111/j.1755-3768.2019.8105
https://doi.org/10.1111/j.1755-3768.2019.8105
Autor:
Ahmad Ahmado, Anthony A. Vugler, Paul J. Whiting, Sakina B Gooljar, Lyndon da Cruz, Tricia Harbinson, Adnan Tufail, Conor M. Ramsden, Anna Wilbrey, Amanda J. Vernon, Mark Whitlock, Kate Fynes, Julie Kerby, Odysseas Georgiadis, Juliette Steer, Mandeep S. Sagoo, Magda Bictash, Peter J. Coffey, Amanda-Jayne F. Carr, Shazeen M Hasan, Yvonne Hsu-Lin Luo, Mike Fenster, Britta Nommiste, Graham E. Holder, Anthony G. Robson, Peter T. Loudon, Julie T. Daniels, Gang Feng
Publikováno v:
Nature Biotechnology. 36:328-337
Age-related macular degeneration (AMD) remains a major cause of blindness, with dysfunction and loss of retinal pigment epithelium (RPE) central to disease progression. We engineered an RPE patch comprising a fully differentiated, human embryonic ste
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6d2e004d8a57eadf8ae9553a3d492e47
https://doi.org/10.1038/nbt.4114
https://doi.org/10.1038/nbt.4114