Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Amanda Weil Harrington"'
Autor:
Robert Blue, Christopher A. LeClair, Marta Filizola, Craig J. Thomas, Mariana Babayeva, Won-Seok Choi, Mark A. Nedelman, Amanda Weil Harrington, Sarasija Naini, Elisabetta Volpi, Jian-kang Jiang, Min Shen, Joseph Fernandez, Andrea Negri, Wenwei Huang, Jihong Li, George A. David, Joshua G. McCoy, Barry S. Coller
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 24:1148-1153
A collection of αIIbβ3 integrin receptor antagonists possessing a unique MIDAS metal ion displacement mechanism of action is presented. Insight into these agents’ structure-activity relationships, binding modality, and pharmacokinetic and pharmac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bf46f8bf19a934abc340a37e8f64cb0
https://doi.org/10.1016/j.bmcl.2013.12.122
https://doi.org/10.1016/j.bmcl.2013.12.122
Autor:
Marketa Jirouskova, Christin A. Janczak, Mortimer Poncz, Marta Murcia, Michael A. Thornton, Jihong Li, Jessica Hirsch, M. Anna Kowalska, Robert Blue, Marta Filizola, Rudy Fuentes, Amanda Weil Harrington, Barry S. Coller
We previously reported on a novel compound (Compound 1; RUC-1) identified by high-throughput screening that inhibits human αIIbβ3. RUC-1 did not inhibit αVβ3, suggesting that it interacts with αIIb, and flexible ligand/rigid protein molecular do
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67c3e716d27b5b99a499d7e1b95171fc
https://europepmc.org/articles/PMC2710948/
https://europepmc.org/articles/PMC2710948/
