Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Amanda W. Hutchins"'
Autor:
Emma L. Baar, Amanda W. Hutchins, Rachel P. Gaither, Yetis Gultekin, Dudley W. Lamming, Ömer H. Yilmaz, Pekka Katajisto, Maria M. Mihaylova, David M. Sabatini
Publikováno v:
Aging Cell
Wiley Blackwell
Wiley Blackwell
Rapamycin, an inhibitor of the mechanistic target of rapamycin (mTOR), robustly extends the lifespan of model organisms including mice. We recently found that chronic treatment with rapamycin not only inhibits mTOR complex 1 (mTORC1), the canonical t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e2a1ab6d08eb04c64f60098fc5ce3d9
http://europepmc.org/articles/PMC4172536
http://europepmc.org/articles/PMC4172536
MCT1-mediated transport of a toxic molecule is an effective strategy for targeting glycolytic tumors
Autor:
Timothy R. Peterson, Yetis Gultekin, Ömer H. Yilmaz, Jan E. Carette, Thijn R Brummelkamp, Kıvanç Birsoy, Catherine E Koch, Richard Possemato, Clary B. Clish, Walter W. Chen, Timothy C. Wang, Amanda W. Hutchins, David M. Sabatini
Publikováno v:
Nature genetics
There is increasing evidence that oncogenic transformation modifies the metabolic program of cells. A common alteration is the upregulation of glycolysis, and efforts to target glycolytic enzymes for anticancer therapy are under way. Here, we perform
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f327ddd6d34efdafd532e2483a9bab4d
http://europepmc.org/articles/PMC3530647
http://europepmc.org/articles/PMC3530647