Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Amanda Tutto"'
Publikováno v:
JVS - Vascular Science, Vol 5, Iss , Pp 100203- (2024)
Objective: The extent of collateral artery enlargement determines the risk of limb loss due to peripheral arterial disease. Hypercholesterolemia impairs collateral artery enlargement, but the underlying mechanism remains poorly characterized. This st
Externí odkaz:
https://doaj.org/article/af27bba6d4ea4e73946b578fec06623a
Autor:
Jinglian Yan, Guodong Tie, Shouying Wang, Amanda Tutto, Natale DeMarco, Lyne Khair, Thomas G. Fazzio, Louis M. Messina
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Type 2 diabetes is associated with impaired wound healing, which can lead to limb loss. Here, the authors show that in Type 2 diabetic mouse models, Dnmt1 is upregulated in hematopoietic stem cells, leading to impaired differentiation towards macroph
Externí odkaz:
https://doaj.org/article/4a2e03c93405462e969dba52018c2d64
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 37
Rationale: Hypercholesterolemia, a major risk factor for cardiovascular disease, also increases all-cause mortality. Previous work from our lab and others has shown that hypercholesterolemia induces an oxidant stress-dependent accelerated ageing of h