Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Amanda S. Messer"'
Autor:
S. Paul Bajaj, Sayeh Agah, Kanagasabai Vadivel, Madhu S. Bajaj, Kaillathe Padmanabhan, Duilio Cascio, Charles T. Esmon, Sriram Krishnaswamy, Amanda S. Messer
Publikováno v:
Journal of Molecular Biology. 425:1961-1981
Crystal structures of factor (F) VIIa/soluble tissue factor (TF), obtained under high Mg(2+) (50mM Mg(2+)/5mM Ca(2+)), have three of seven Ca(2+) sites in the γ-carboxyglutamic acid (Gla) domain replaced by Mg(2+) at positions 1, 4, and 7. We now re
Autor:
Stephen B. Smith, David Gailani, Mao-fu Sun, Yipeng Geng, S. Paul Bajaj, Ingrid M. Verhamme, Amanda S. Messer
Publikováno v:
Journal of Biological Chemistry. 287:38200-38209
During blood coagulation, the protease factor XIa (fXIa) activates factor IX (fIX). We describe a new mechanism for this process. FIX is cleaved initially after Arg(145) to form fIXα, and then after Arg(180) to form the protease fIXaβ. FIXα is rel
Autor:
Mostafa Fatemi, William H. Velander, Martin L. Phillips, Amanda S. Messer, Kanagasabai Vadivel, S. Paul Bajaj, Weijie Xu, Nicholas C. Vanderslice
Publikováno v:
Analytical biochemistry. 479
This study uses high-pressure size exclusion chromatography (HPSEC) to quantify divalent metal ion (X(2+))-induced compaction found in vitamin K-dependent (VKD) proteins. Multiple X(2+) binding sites formed by the presence of up to 12 γ-carboxygluta
Autor:
Yipeng Geng, Ingrid M. Verhamme, Mao-fu Sun, S. Paul Bajaj, Jonas Emsley, Amanda S. Messer, David Gailani
Factor XI (fXI) is the zymogen of a plasma protease, factor XIa (fXIa), that contributes to thrombin generation during blood coagulation by proteolytic conversion of factor IX (fIX) to factor IXaβ (fIXaβ). There is considerable interest in fXIa as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa9bbcd2256d1c1280009606172245d7
https://europepmc.org/articles/PMC4017667/
https://europepmc.org/articles/PMC4017667/
Publikováno v:
Journal of thrombosis and haemostasis : JTH. 7(12)
rs4962153 showed an association with cryptogenic stroke(Table 1). This association is interesting in view of the fact thatprothrombotic variants have been suggested as risk factors forcryptogenicstroke[8],buttherearenostudiesonADAMTS13in this subtype
Autor:
Mao-fu Sun, Amanda S. Messer, Yipeng Geng, David Gailani, Ingrid M. Verhamme, Stephen B. Smith, S. Paul Bajaj
Publikováno v:
Blood. 118:2235-2235
Abstract 2235 Conversion of factor IX (fIX) to the protease factor IXaβ (fIXaβ) is an important reaction during thrombin generation at a site of vascular injury. The physiologic activators of fIX are the proteases factor VIIa and factor XIa (fXIa).
Autor:
Sayeh Agah, Kaillathe Padmanabhan, S. Paul Bajaj, Kanagasabai Vadivel, Sriram Krishnaswamy, Charles T. Esmon, Madhu S. Bajaj, Amanda S. Messer, Duilio Cascio
Publikováno v:
Blood. 118:1172-1172
Abstract 1172 Equilibrium dialysis experiments indicate that the Gla domain of coagulant protein factor (F) VIIa and of anticoagulant protein C (PC) each bind seven Ca2+ in the absence and four in the presence of physiologic Mg2+ (0.6 mM). The previo