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pro vyhledávání: '"Amanda S. Hirata"'
Autor:
Rodrigo dos A. Miguel, Amanda S. Hirata, Paula C. Jimenez, Luciana B. Lopes, Leticia V. Costa-Lotufo
Publikováno v:
Pharmaceutics, Vol 14, Iss 8, p 1722 (2022)
Nature is the largest pharmacy in the world. Doxorubicin (DOX) and paclitaxel (PTX) are two examples of natural-product-derived drugs employed as first-line treatment of various cancer types due to their broad mechanisms of action. These drugs are ma
Externí odkaz:
https://doaj.org/article/6ef0b5c6a7414b3486f4d79623ba8322
Autor:
Amanda S. Hirata, James J. La Clair, Paula C. Jimenez, Leticia Veras Costa-Lotufo, William Fenical
Publikováno v:
Marine Drugs, Vol 20, Iss 5, p 301 (2022)
The bioactive natural product seriniquinone was discovered as a potential melanoma drug, which was produced by the as-yet-undescribed marine bacterium of the rare genus Serinicoccus. As part of a long-term research program aimed at the discovery of n
Externí odkaz:
https://doaj.org/article/083a8b8867334737a50b6bdd51c4f162
Autor:
Amanda S. Hirata, Paula Rezende-Teixeira, João Agostinho Machado-Neto, Paula C. Jimenez, James J. La Clair, William Fenical, Leticia V. Costa-Lotufo
Publikováno v:
Molecules, Vol 26, Iss 23, p 7362 (2021)
Isolated from the marine bacteria Serinicoccus sp., seriniquinone (SQ1) has been characterized by its selective activity in melanoma cell lines marked by its modulation of human dermcidin and induction of autophagy and apoptosis. While an active lead
Externí odkaz:
https://doaj.org/article/1232328600ab494ab287304dcff5d3b4