Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Amanda S. Coutts"'
Autor:
Arnold Tan, Awais Z. Younis, Alexander Evans, Jade V. Creighton, Clare Coveny, David J. Boocock, Craig Sale, Gareth G. Lavery, Amanda S. Coutts, Craig L. Doig
Publikováno v:
Cell Death Discovery, Vol 9, Iss 1, Pp 1-13 (2023)
Abstract The ADP-ribosyltransferase, PARP1 enzymatically generates and applies the post-translational modification, ADP-Ribose (ADPR). PARP1 roles in genome maintenance are well described, but recent work highlights roles in many fundamental processe
Externí odkaz:
https://doaj.org/article/53b6b599c8154c79ab5165547b13a0c9
The tumour suppressor p53 is a nuclear transcription factor with key roles during DNA damage to enable a variety of cellular responses including cell cycle arrest, apoptosis and DNA repair. JMY is an actin nucleator and DNA damage-responsive protein
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5dd1f84a46d695e7ece99643fca6a5b5
https://doi.org/10.21203/rs.3.rs-1925129/v1
https://doi.org/10.21203/rs.3.rs-1925129/v1
Autor:
Amanda S. Coutts, Louise Weston
Publikováno v:
Methods in Molecular Biology ISBN: 9781071615379
Methods in Molecular Biology ISBN: 9781493929566
Cell Cycle Oscillators
Methods in Molecular Biology ISBN: 9781493929566
Cell Cycle Oscillators
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f3107c55b3b7bd8f37444bb2ef8beec
https://doi.org/10.1007/978-1-0716-1538-6
https://doi.org/10.1007/978-1-0716-1538-6
Autor:
Enrique Amaya, Imad M. Awan, Hugo J. Bellen, Alessandro Bertero, David Brindley, Stephanie Brown, Eleanor Jane Budge, Eleni Chantzoura, John Collin, Amanda S. Coutts, Karel Dorey, Jefte M. Drijvers, Tomasz Gwozdz, Gregory A. Hawkins, Shoko Ishibashi, Tyler Jacks, Mehdi Jalali, Morteza Jalali, Sonali Joshi, Keisuke Kaji, Nicholas B. La Thangue, Laurens J. Lambert, Robert Lea, Martyna Lukoseviciute, Paul Martin, Mandar D. Muzumdar, Frederick D. Park, Cory A. Perugino, Adam Pettitt, David Pettitt, Shiv Pillai, Tannishtha Reya, William M. Rideout, MacKenna Roberts, Ian M. Rosenberg, Francesca Y.L. Saldanha, Roman Sasik, Charis-P. Segeritz, Semira Sheikh, James Smith, Ludovic Vallier, Michael F. Wangler, Dihua Yu, Justyna Zaborowska
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9d10cd44acceecb1af07e50a4bf1145b
https://doi.org/10.1016/b978-0-12-803077-6.00024-2
https://doi.org/10.1016/b978-0-12-803077-6.00024-2
Over the last 30 years, the transfection of DNA or RNA into mammalian cells has evolved into an ever more sophisticated research tool for the investigation of gene expression and protein function. Transfection is used to describe the process of intro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::753fbd788a577d42d41155c5e00e2538
https://doi.org/10.1016/b978-0-12-803077-6.00011-4
https://doi.org/10.1016/b978-0-12-803077-6.00011-4
Autor:
Omanma Adighibe, N B La Thangue, K C Gatter, R Leek, Helen Turley, Amanda S. Coutts, Adrian L. Harris, Francesco Pezzella
Publikováno v:
Virchows Archiv. 465:715-722
JMY is a p300-binding protein with dual action: by enhancing P53 transcription in the nucleus, it plays an important role in the cellular response to DNA damage, while by promoting actin filament assembly in the cytoplasm; it induces cell motility in
E2F activity is negatively regulated by retinoblastoma protein (pRb) through binding to the E2F-1 subunit. Within the E2F heterodimer, DP proteins are E2F partner subunits that allow proper cell cycle progression. In contrast to the other DP proteins
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a2b0455d6463d31c00d14ed12d69ca1
https://ora.ox.ac.uk/objects/uuid:a09ecf81-9b71-4b9e-b067-f354c4735a7f
https://ora.ox.ac.uk/objects/uuid:a09ecf81-9b71-4b9e-b067-f354c4735a7f
Autor:
Joanna F. McGouran, Dermot Kerr, Omar Khan, Lindsay Stimson, Amanda S. Coutts, Heidi Olzscha, Geng Liu, Mark R. Middleton, Maria I. New, N B La Thangue, Benedikt M. Kessler
Histone deacetylase (HDAC) is an emergent anticancer target, and HR23B is a biomarker for response to HDAC inhibitors. We show here that HR23B has impacts on two documented effects of HDAC inhibitors; HDAC inhibitors cause apoptosis in cells expressi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb1ff7c330fe7f80fca6bb7be29be454
https://doi.org/10.1038/cdd.2013.47
https://doi.org/10.1038/cdd.2013.47
Summary Actin is an integral component of the cytoskeleton, forming a plethora of macromolecular structures that mediate various cellular functions. The formation of such structures relies on the ability of actin monomers to associate into polymers,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71fc8299f9b198f127d1dc8b6e4145dd
https://doi.org/10.1242/jcs.099523
https://doi.org/10.1242/jcs.099523
We define here a new mechanism through which Mdm2 (mouse double minute 2) regulates p53 activity, by targeting the p53 transcription cofactor JMY. DNA damage causes an increase in JMY protein, and, in a similar manner, small molecule inhibitors of Md
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d979d7b4738864ea53fdc0262cf807e7
https://ora.ox.ac.uk/objects/uuid:355b2ad1-9807-483f-beb4-427936a72544
https://ora.ox.ac.uk/objects/uuid:355b2ad1-9807-483f-beb4-427936a72544