Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Amanda R. Waxman"'
Autor:
Jin Xu, Zhigang Lu, Mingming Xu, Grace C Rossi, Benjamin Kest, Amanda R Waxman, Gavril W Pasternak, Ying-Xian Pan
Publikováno v:
PLoS ONE, Vol 9, Iss 10, p e111267 (2014)
The µ opioid receptor gene, OPRM1, undergoes extensive alternative pre-mRNA splicing in rodents and humans, with dozens of alternatively spliced variants of the OPRM1 gene. The present studies establish a SYBR green quantitative PCR (qPCR) assay to
Externí odkaz:
https://doaj.org/article/f26ad640c95a45f59b253d8d98102d05
Autor:
Maarten Swartjes, Koen van de Wetering, Jos H Beijnen, Albert Dahan, Amanda R. Waxman, Jan den Hartigh, Caroline A. Arout, Benjamin Kest, René Mooren
Publikováno v:
Molecular Medicine. 18:1320-1326
Opioid-induced hyperalgesia (OIH) is a paradoxical increase in pain perception that may manifest during opioid treatment. For morphine, the metabolite morphine-3-glucuronide (M3G) is commonly believed to underlie this phenomenon. Here, in three separ
Publikováno v:
Neuropsychological Rehabilitation. 22:40-64
Failures of prospective memory (PM) are one of the most frequent, and least studied, sequelae of brain injury. PM, also referred to as memory for intentions, is the ability to remember to carry out a future task. Successful completion of a PM task re
Publikováno v:
Neuroscience Letters. 462:68-72
Although μ-receptor opioids are clinically important analgesics, they can also paradoxically cause hyperalgesia independently of opioid receptor activity, presumably via the action of neuroexcitatory glucoronide metabolites. However, it is unknown w
Autor:
Benjamin Kest, Gad Klein, Charles E. Inturrisi, Grace C. Rossi, Amanda R. Waxman, Carolne Arout, Aaron Juni
Publikováno v:
Neuroscience Letters. 457:115-119
Although morphine and heroin analgesia is mediated by mu-opioid receptors encoded by the MOR-1 gene, distinct isoforms are involved. Both opioids also induce dependence by acting at mu-opioid receptors, but which variants are utilized is not known. H
Autor:
Todd D. Williams, Joel K. Elmquist, Amanda R. Waxman, Jeffrey M. Zigman, Juli E. Jones, Charlotte E. Lee, Yoshihide Nakano, Nina Balthasar, Bradford B. Lowell, Amy E. Deysher, Jennifer Lachey, Randy J. Seeley, Jacob Marcus, Roberto Coppari, Ryan D. White
Publikováno v:
Journal of Clinical Investigation. 115:3564-3572
Ghrelin is the endogenous ligand for the growth hormone secretagogue receptor (GHSR; ghrelin receptor). Since its discovery, accumulating evidence has suggested that ghrelin may play a role in signaling and reversing states of energy insufficiency. F
Autor:
Laura C, Reigada, Jean-Marie, Bruzzese, Keith J, Benkov, Joseph, Levy, Amanda R, Waxman, Eva, Petkova, Carrie Masia, Warner
Publikováno v:
Journal for specialists in pediatric nursing : JSPN. 16(3)
PURPOSE. Adolescents with inflammatory bowel disease (IBD) may be at heightened risk for developing anxiety and depression. This cross-sectional pilot study examined the relationship between anxiety and depression and health-related behaviors. METHOD
Autor:
Minying Cai, Caroline A. Arout, Benjamin Kest, Victor J. Hruby, Magda Stankova, Aaron Juni, Gad Klein, Jeffrey S. Mogil, Albert Dahan, Amanda R. Waxman
Publikováno v:
Anesthesiology, 112(1), 181-188
Sustained morphine delivery can paradoxically enhance pain sensitivity in humans1,2 and nociceptive behavior in rodents.3,4 This opioid-induced hyperalgesia is obviously a major challenge to the clinical treatment of pain, for which μ-opioid agonist
Autor:
William J. Kowalczyk, Benjamin Kest, Caroline A. Arout, Aurora Morariu, Albert Dahan, Amanda R. Waxman, Eveline L. A. van Dorp, Elise Sarton
Publikováno v:
Anesthesiology. 110(6)
Background Previous data indicate that morphine-6beta-glucuronide (M6G), a morphine metabolite with analgesic properties, can paradoxically increase pain sensitivity in mice and humans. The authors tested mice and humans for M6G hyperalgesia and asse
Publikováno v:
Anesthesia and analgesia. 107(1)
It is widely reported that analgesic drugs acting at mu, kappa, and delta opioid-receptors display quantitative and qualitative differences in effect in males and females. These sex-related differences are not restricted to the analgesic/antinocicept