Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Amanda R. Krysler"'
Autor:
Edward N. Schmidt, Dimitra Lamprinaki, Kelli A. McCord, Maju Joe, Mirat Sojitra, Ayk Waldow, Jasmine Nguyen, John Monyror, Elena N. Kitova, Fahima Mozaneh, Xue Yan Guo, Jaesoo Jung, Jhon R. Enterina, Gour C. Daskhan, Ling Han, Amanda R. Krysler, Christopher R. Cromwell, Basil P. Hubbard, Lori J. West, Marianne Kulka, Simonetta Sipione, John S. Klassen, Ratmir Derda, Todd L. Lowary, Lara K. Mahal, Meghan R. Riddell, Matthew S. Macauley
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract Immunomodulatory Siglecs are controlled by their glycoprotein and glycolipid ligands. Siglec-glycolipid interactions are often studied outside the context of a lipid bilayer, missing the complex behaviors of glycolipids in a membrane. Throug
Externí odkaz:
https://doaj.org/article/1b849c2f9a814c4e9507f12b5f5f0d43
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
Genetic variance poses a major challenge for CRISPR-based human therapeutics and pathogen diagnostics. Here the authors show how to circumvent this issue by using guide RNAs containing universal bases to tailor Cas9/Cas12 specificity.
Externí odkaz:
https://doaj.org/article/05aecea7448d40ce9fa4e4f1e8e0c8f7
Autor:
Christopher R. Cromwell, Keewon Sung, Jinho Park, Amanda R. Krysler, Juan Jovel, Seong Keun Kim, Basil P. Hubbard
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
Minimizing off-target effects is an important concern for therapeutic applications of CRISPR-Cas9. Here, the authors show that incorporating bridged or locked nucleic acids into crRNA improves editing kinetics and reduces off-target cleavage.
Externí odkaz:
https://doaj.org/article/73e57431c7cf40ba9361ba99c2c9360d
Autor:
Aristeidis E. Boukouris, Yongneng Zhang, Bruno Saleme, Adam Kinnaird, Yuan Yuan Zhao, Yongsheng Liu, Sotirios D. Zervopoulos, Subhash K. Das, Rohan D. Mittal, Alois Haromy, Maria Areli Lorenzana-Carrillo, Amanda R. Krysler, Christopher R. Cromwell, Basil P. Hubbard, Gopinath Sutendra, Evangelos D. Michelakis
Publikováno v:
Cell Reports. 38:110511
An epithelial-to-mesenchymal transition (EMT) phenotype with cancer stem cell-like properties is a critical feature of aggressive/metastatic tumors, but the mechanism(s) that promote it and its relation to metabolic stress remain unknown. Here we sho
Autor:
Basil P. Hubbard, Juan Jovel, Keewon Sung, Amanda R. Krysler, Seong Keun Kim, Jinho Park, Christopher R Cromwell
Publikováno v:
Nature Communications
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
Off-target DNA cleavage is a paramount concern when applying CRISPR-Cas9 gene-editing technology to functional genetics and human therapeutic applications. Here, we show that incorporation of next-generation bridged nucleic acids (2′,4′-BNANC[N-M
Publikováno v:
Behavioural Processes. 98:98-105
In temperate songbirds, song has traditionally been considered a vocalization mainly produced by males. However, in many temperate species, it is now recognized that both males and females produce song. The function and structure of male black-capped