Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Amanda Przedpelski"'
Autor:
Polrit Viravathana, William H. Tepp, Marite Bradshaw, Amanda Przedpelski, Joseph T. Barbieri, Sabine Pellett
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 16, p 8955 (2024)
Recombinant mutant holotoxin BoNTs (rBoNTs) are being evaluated as possible vaccines against botulism. Previously, several rBoNTs containing 2–3 amino acid mutations in the light chain (LC) showed significant decreases in toxicity (2.5-million-fold
Externí odkaz:
https://doaj.org/article/72e9e709ba85446a9e0ce777b80a3725
Autor:
Davide Oldrini, Roberta Di Benedetto, Martina Carducci, Daniele De Simone, Luisa Massai, Renzo Alfini, Barbara Galli, Brunella Brunelli, Amanda Przedpelski, Joseph T. Barbieri, Omar Rossi, Carlo Giannelli, Rino Rappuoli, Francesco Berti, Francesca Micoli
Publikováno v:
Vaccines, Vol 11, Iss 12, p 1770 (2023)
Glycoconjugate vaccines play a major role in the prevention of infectious diseases worldwide, with significant impact on global health, enabling the polysaccharides to induce immunogenicity in infants and immunological memory. Tetanus toxoid (TT), a
Externí odkaz:
https://doaj.org/article/dc3558a323a5433b8ca23f7e05639875
Publikováno v:
mBio, Vol 11, Iss 4 (2020)
ABSTRACT Chemically inactivated tetanus toxoid (CITT) is clinically effective and widely used. However, CITT is a crude nonmalleable vaccine that contains hundreds of Clostridium tetani proteins, and the active component is present in variable and so
Externí odkaz:
https://doaj.org/article/6beab9842e624c3b89a53789ea92360a
Autor:
Chen Chen, Amanda Przedpelski, William H. Tepp, Sabine Pellett, Eric A. Johnson, Joseph T. Barbieri
Publikováno v:
mBio, Vol 6, Iss 4 (2015)
ABSTRACT Cholera toxin (CT) and the related heat-labile enterotoxins (LT) of Escherichia coli have been implicated as adjuvants in human therapies, but reactivity upon intranasal delivery dampened efforts to develop other clinical applications. Howev
Externí odkaz:
https://doaj.org/article/047bf271092a48c4b5f560d996958c4d
Autor:
Min-Ju Chang, Morgane Ollivault-Shiflett, Richard Schuman, Son Ngoc Nguyen, Igor A. Kaltashov, Cedric Bobst, Shalini P. Rajagopal, Amanda Przedpelski, Joseph T. Barbieri, Andrew Lees
Publikováno v:
Vaccine. 40(35)
Tetanus toxoid (TTxd), developed over 100 years ago, is a clinically effective, legacy vaccine against tetanus. Due to the extreme potency of native tetanus toxin, manufacturing and regulatory efforts often focus on TTxd production, standardization,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::355efcf0e411bc50b08fb8a41669fe19
https://pubmed.ncbi.nlm.nih.gov/35871872
https://pubmed.ncbi.nlm.nih.gov/35871872
Publikováno v:
mBio, Vol 11, Iss 4 (2020)
mBio
mBio
Chemical inactivation is a clinically effective mechanism to detoxify protein toxins to produce vaccines against microbial infections and to serve as a platform for production of conjugate polysaccharide vaccines. This method is widely used for the p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a99e2d5ac8fe19b77efc3010121a54ec
https://journals.asm.org/doi/10.1128/mBio.01668-20
https://journals.asm.org/doi/10.1128/mBio.01668-20
Autor:
Madison Zuverink, Eric A. Johnson, Sabine Pellet, Joseph T. Barbieri, Amanda Przedpelski, William H. Tepp
Publikováno v:
Vaccine. 36:827-832
Botulinum neurotoxins (BoNT) are the most toxic proteins for humans. BoNTs are single chain proteins with an N-terminal light chain (LC) and a C-terminal heavy chain (HC). HC comprises a translocation domain (HCN) and a receptor binding domain (HCC).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2722ba9b0f08ebbec75befca0e199ac
https://doi.org/10.1016/j.vaccine.2017.12.064
https://doi.org/10.1016/j.vaccine.2017.12.064
Autor:
Zhuji Fu, Amanda Przedpelski, Abby R. Kroken, William H. Tepp, Joseph T. Barbieri, Eric A. Johnson, Jung-Ja P. Kim
Publikováno v:
Infection and Immunity. 81:2638-2644
The need for a vaccine against botulism has increased since the discontinuation of the pentavalent (ABCDE) botulinum toxoid vaccine by the Centers for Disease Control and Prevention. The botulinum toxins (BoNTs) are the primary virulence factors and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e831b5f2f819282521f58ea7f32bda1
https://doi.org/10.1128/iai.00382-13
https://doi.org/10.1128/iai.00382-13
Autor:
James S. Henkel, Amanda Przedpelski, Robert B. Fritz, Joseph T. Barbieri, Eric A. Johnson, William H. Tepp
Publikováno v:
Vaccine. 29:7688-7695
Botulinum neurotoxins (BoNT) are classified into 7 serotypes (A-G) based upon neutralization by serotype-specific anti-sera. Several recombinant serotype-specific subunit BoNT vaccines have been developed, including a subunit vaccine comprising the r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e633d959fa7750569700fcf951f900ce
https://doi.org/10.1016/j.vaccine.2011.07.134
https://doi.org/10.1016/j.vaccine.2011.07.134
Autor:
Sabine Pellett, William H. Tepp, Amanda Przedpelski, Chen Chen, Eric A. Johnson, Joseph T. Barbieri
Publikováno v:
mBio, Vol 6, Iss 4 (2015)
mBio
mBio
Cholera toxin (CT) and the related heat-labile enterotoxins (LT) of Escherichia coli have been implicated as adjuvants in human therapies, but reactivity upon intranasal delivery dampened efforts to develop other clinical applications. However, each
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ca5bcd11d9052e4253dee19a4eec450
https://doi.org/10.1128/mbio.00734-15
https://doi.org/10.1128/mbio.00734-15