Tumor analysis: freeze–thawing cycle of triple-negative breast cancer cells alters tumor CD24/CD44 profiles and the percentage of tumor-infiltrating immune cells

Autor: Matthieu Le Gallo, Thibault de la Motte Rouge, Amanda Poissonnier, Vincent Lavoué, Patrick Tas, Jean Leveque, Florence Godey, Patrick Legembre

Publikováno v: BMC Research Notes, Vol 11, Iss 1, Pp 1-20 (2018)

Abstract Objective The use of novel methods to characterize living tumor cells relies on well-conceived biobanks. Herein, we raised the question of whether the composition of fresh and freeze/thawed dissociated tumor samples is comparable in terms of

Externí odkaz: https://doaj.org/article/77ca2f5f17a8407a9cef41a05b63b51d

Chemotherapy elicits pro-metastatic extracellular vesicles in breast cancer models

Autor: Aditya Bardia, Lore Lambein, Rakesh K. Jain, Simon Tazzyman, Lisa M. Coussens, Mario Leonardo Squadrito, Laura Spring, Ioanna Keklikoglou, Alan Guichard, Claire E. Lewis, Michele De Palma, Chiara Cianciaruso, Jeffrey W. Pollard, Esra Güç, Antonino M. Cassarà, Gino B. Ferraro, M. Luisa Iruela-Arispe, Caroline Baer, Amanda Poissonnier

Publikováno v: Keklikoglou, I, Cianciaruso, C, Guc, E, Squadrito, M L, Spring, L M, Tazzyman, S, Lambein, L, Poissonnier, A, Ferraro, G B, Baer, C, Cassara, A, Guichard, A, Iruela-Arispe, M L, Lewis, C E, Coussens, L M, Bardia, A, Jain, R K, Pollard, J W & De Palma, M 2019, ' Chemotherapy elicits pro-metastatic extracellular vesicles in breast cancer models ', Nature Cell Biology, vol. 21, no. 2, pp. 190–202 . https://doi.org/10.1038/s41556-018-0256-3
Nature Cell Biology

Cytotoxic chemotherapy is an effective treatment for invasive breast cancer. However, experimental studies in mice also suggest that chemotherapy has pro-metastatic effects. Primary tumours release extracellular vesicles (EVs), including exosomes, th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a174dddce8c60225342213d9add0b61
https://doi.org/10.1038/s41556-018-0256-3

Synthesis of peptidomimetics and chemo-biological tools for CD95/PLCγ1 interaction analysis

Autor: Nicolas Levoin, Patrick Legembre, Amanda Poissonnier, Pierre van de Weghe, Ha Thanh Nguyen, Daniel Best, Mickael Jean, Pierre Vacher, Jean-Philippe Guégan, Florence Jouan

Publikováno v: Bioorganic and Medicinal Chemistry Letters
Bioorganic and Medicinal Chemistry Letters, 2019, 29 (16), pp.2094-2099. ⟨10.1016/j.bmcl.2019.07.006⟩
Bioorganic and Medicinal Chemistry Letters, Elsevier, 2019, 29 (16), pp.2094-2099. ⟨10.1016/j.bmcl.2019.07.006⟩

The death receptor CD95 (also known as Fas) induces apoptosis through protein/protein association and the formation of the death-inducing signaling complex. On the other hand, in certain biological conditions, this receptor recruits different protein

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f808a922d1329477abc13c81e64d3f74
https://pubmed.ncbi.nlm.nih.gov/31301931

Disrupting the CD95-PLC gamma 1 interaction prevents Th17-driven inflammation

Autor: Patrick Blanco, Amanda Poissonnier, Nicolas Levoin, Patrick Legembre, Lucie Morere, Pierre van de Weghe, Guennadi Kozlov, Sophie Martin, Isabelle Douchet, Ha Thanh Nguyen, Estibaliz Lazaro, Daniel Best, Raphael Pineau, Melissa Thomas, Jean-Philippe Guégan, Mickael Jean, Thomas Ducret, Pierre Vacher, Florence Jouan, Kalle Gehring

Publikováno v: Nature Chemical Biology
Nature Chemical Biology, Nature Publishing Group, 2018, 14 (12), pp.1079-+. ⟨10.1038/s41589-018-0162-9⟩
Nature Chemical Biology, 2018, 14 (12), pp.1079-+. ⟨10.1038/s41589-018-0162-9⟩

International audience; CD95L is a transmembrane ligand (m-CD95L) that is cleaved by metalloproteases to release a soluble ligand (s-CD95L). Unlike m-CD95L, interaction between s-CD95L and CD95 fails to recruit caspase-8 and FADD to trigger apoptosis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee2a326251f972d1a41a88857f53e694
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01976911

T cell landscape in triple negative breast cancer patients

Autor: Patrick Legembre, Amanda Poissonnier, M. Le Gallo, Florence Godey

Publikováno v: Breast
Breast, Elsevier, 2017, 32, pp.S99--S99. ⟨10.1016/S0960-9776(17)30314-4⟩
Breast, 2017, 32, pp.S99--S99. ⟨10.1016/S0960-9776(17)30314-4⟩

International audience; 15th St.Gallen International Breast Cancer Conference - P228

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5c8d650930a6e265803d66dc8e6a16d
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01543367