Zobrazeno 1 - 10
of 80
pro vyhledávání: '"Amanda Phipps-Green"'
Autor:
Hailemichael Z. Hishe, Sophie L. Stocker, Lisa K. Stamp, Nicola Dalbeth, Tony R. Merriman, Amanda Phipps‐Green, Daniel F. B. Wright
Publikováno v:
Clinical and Translational Science, Vol 16, Iss 3, Pp 422-428 (2023)
Abstract The genetic determinants of the allopurinol dose‐concentration relationship have not been extensively studied. We aimed to clarify what factors, including genetic variation in urate transporters, influence oxypurinol pharmacokinetics (PKs)
Externí odkaz:
https://doaj.org/article/2aebadf1e0614baaab3b5062fe752885
Autor:
Jaye Moors, Mohanraj Krishnan, Nick Sumpter, Riku Takei, Matt Bixley, Murray Cadzow, Tanya J. Major, Amanda Phipps-Green, Ruth Topless, Marilyn Merriman, Malcolm Rutledge, Ben Morgan, Jenna C. Carlson, Jerry Z. Zhang, Emily M. Russell, Guangyun Sun, Hong Cheng, Daniel E. Weeks, Take Naseri, Muagututi’a Sefuiva Reupena, Satupa’itea Viali, John Tuitele, Nicola L. Hawley, Ranjan Deka, Stephen T. McGarvey, Janak de Zoysa, Rinki Murphy, Nicola Dalbeth, Lisa Stamp, Mele Taumoepeau, Frances King, Phillip Wilcox, Nuku Rapana, Sally McCormick, Ryan L. Minster, Tony R. Merriman, Megan Leask
Publikováno v:
HGG Advances, Vol 4, Iss 3, Pp 100204- (2023)
Summary: Identifying population-specific genetic variants associated with disease and disease-predisposing traits is important to provide insights into the genetic determinants of health and disease between populations, as well as furthering genomic
Externí odkaz:
https://doaj.org/article/7af5bffb2a1a41c9a4a3264dd197c255
Autor:
Anne-Katrin Emde, Amanda Phipps-Green, Murray Cadzow, C. Scott Gallagher, Tanya J. Major, Marilyn E. Merriman, Ruth K. Topless, Riku Takei, Nicola Dalbeth, Rinki Murphy, Lisa K. Stamp, Janak de Zoysa, Philip L. Wilcox, Keolu Fox, Kaja A. Wasik, Tony R. Merriman, Stephane E. Castel
Publikováno v:
BMC Genomics, Vol 22, Iss 1, Pp 1-14 (2021)
Abstract Background Historically, geneticists have relied on genotyping arrays and imputation to study human genetic variation. However, an underrepresentation of diverse populations has resulted in arrays that poorly capture global genetic variation
Externí odkaz:
https://doaj.org/article/295efebb8290477c8a164ca0f7d5bfec
Autor:
Philip C. Robinson, Christopher Frampton, Amanda Phipps-Green, Tuhina Neogi, Lisa Stamp, William Taylor, Tony R. Merriman, Nicola Dalbeth
Publikováno v:
BMC Rheumatology, Vol 5, Iss 1, Pp 1-8 (2021)
Abstract Introduction Elevated serum urate (SU) concentration is the central risk factor for the development of gout. The aim of this study was to examine the incidence of gout in people with low and normal SU levels ( 7.00 mg/dL was 12.2%. In an adj
Externí odkaz:
https://doaj.org/article/902e9ab999264dc0bc7a8dbce65000b5
Autor:
Ruth K. Topless, Amanda Phipps‐Green, Megan Leask, Nicola Dalbeth, Lisa K. Stamp, Philip C. Robinson, Tony R. Merriman
Publikováno v:
ACR Open Rheumatology, Vol 3, Iss 5, Pp 333-340 (2021)
Objectives The objectives for this study were to assess whether gout and/or rheumatoid arthritis (RA) are risk factors for coronavirus disease 2019 (COVID‐19) diagnosis and to assess whether gout and/or RA are risk factors for death from COVID‐19
Externí odkaz:
https://doaj.org/article/29bf3bc0e3b44887b2c06327da9b1aae
Autor:
Sarah Stewart, Amanda Phipps-Green, Greg D. Gamble, Lisa K. Stamp, William J. Taylor, Tuhina Neogi, Tony R. Merriman, Nicola Dalbeth
Publikováno v:
PLoS ONE, Vol 17, Iss 2 (2022)
Elevated serum urate is the most important causal risk factor for developing gout. However, in longitudinal cohort studies, a small proportion of people with normal urate levels develop gout and the majority of those with high urate levels do not. Th
Externí odkaz:
https://doaj.org/article/8548a03b48f1419ca2a265539c3c219c
Autor:
Ravi K. Narang, Zoe Vincent, Amanda Phipps-Green, Lisa K. Stamp, Tony R. Merriman, Nicola Dalbeth
Publikováno v:
Arthritis Research & Therapy, Vol 21, Iss 1, Pp 1-9 (2019)
Abstract Background Reduced renal clearance of uric acid is a major contributor to hyperuricemia. The aim of this study was to examine clinical and genetic variables associated with fractional excretion of uric acid (FEUA). Methods Participants (with
Externí odkaz:
https://doaj.org/article/3c2d3a2d1a1a49ccaf8643620eb7ec1b
Autor:
Patrick Chung, Warren B. Logge, Benjamin C. Riordan, Paul S. Haber, Marilyn E. Merriman, Amanda Phipps-Green, Ruth K. Topless, Tony R. Merriman, Tamlin Conner, Kirsten C. Morley
Publikováno v:
Frontiers in Psychiatry, Vol 11 (2020)
Background: Risk behaviors for young adults such as alcohol use are associated with increased risk of morbidity and mortality. Patterns of risk behavior may be genetically determined and vary between genders. Previous studies in both young adults and
Externí odkaz:
https://doaj.org/article/f8d9a4f3ed504d908a1b7994938c8981
Autor:
Jennifer E Huffman, Eva Albrecht, Alexander Teumer, Massimo Mangino, Karen Kapur, Toby Johnson, Zoltán Kutalik, Nicola Pirastu, Giorgio Pistis, Lorna M Lopez, Toomas Haller, Perttu Salo, Anuj Goel, Man Li, Toshiko Tanaka, Abbas Dehghan, Daniela Ruggiero, Giovanni Malerba, Albert V Smith, Ilja M Nolte, Laura Portas, Amanda Phipps-Green, Lora Boteva, Pau Navarro, Asa Johansson, Andrew A Hicks, Ozren Polasek, Tõnu Esko, John F Peden, Sarah E Harris, Federico Murgia, Sarah H Wild, Albert Tenesa, Adrienne Tin, Evelin Mihailov, Anne Grotevendt, Gauti K Gislason, Josef Coresh, Pio D'Adamo, Sheila Ulivi, Peter Vollenweider, Gerard Waeber, Susan Campbell, Ivana Kolcic, Krista Fisher, Margus Viigimaa, Jeffrey E Metter, Corrado Masciullo, Elisabetta Trabetti, Cristina Bombieri, Rossella Sorice, Angela Döring, Eva Reischl, Konstantin Strauch, Albert Hofman, Andre G Uitterlinden, Melanie Waldenberger, H-Erich Wichmann, Gail Davies, Alan J Gow, Nicola Dalbeth, Lisa Stamp, Johannes H Smit, Mirna Kirin, Ramaiah Nagaraja, Matthias Nauck, Claudia Schurmann, Kathrin Budde, Susan M Farrington, Evropi Theodoratou, Antti Jula, Veikko Salomaa, Cinzia Sala, Christian Hengstenberg, Michel Burnier, Reedik Mägi, Norman Klopp, Stefan Kloiber, Sabine Schipf, Samuli Ripatti, Stefano Cabras, Nicole Soranzo, Georg Homuth, Teresa Nutile, Patricia B Munroe, Nicholas Hastie, Harry Campbell, Igor Rudan, Claudia Cabrera, Chris Haley, Oscar H Franco, Tony R Merriman, Vilmundur Gudnason, Mario Pirastu, Brenda W Penninx, Harold Snieder, Andres Metspalu, Marina Ciullo, Peter P Pramstaller, Cornelia M van Duijn, Luigi Ferrucci, Giovanni Gambaro, Ian J Deary, Malcolm G Dunlop, James F Wilson, Paolo Gasparini, Ulf Gyllensten, Tim D Spector, Alan F Wright, Caroline Hayward, Hugh Watkins, Markus Perola, Murielle Bochud, W H Linda Kao, Mark Caulfield, Daniela Toniolo, Henry Völzke, Christian Gieger, Anna Köttgen, Veronique Vitart
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0119752 (2015)
We tested for interactions between body mass index (BMI) and common genetic variants affecting serum urate levels, genome-wide, in up to 42569 participants. Both stratified genome-wide association (GWAS) analyses, in lean, overweight and obese indivi
Externí odkaz:
https://doaj.org/article/adaf5b3ebb05477891a1b783a439bd5e
Autor:
Anna L Mitchell, Katie D R Macarthur, Earn H Gan, Lucy E Baggott, Anette S B Wolff, Beate Skinningsrud, Hazel Platt, Andrea Short, Anna Lobell, Olle Kämpe, Sophie Bensing, Corrado Betterle, Anna Kasperlik-Zaluska, Magdalena Zurawek, Marta Fichna, Ingrid Kockum, Gabriel Nordling Eriksson, Olov Ekwall, Jeanette Wahlberg, Per Dahlqvist, Anna-Lena Hulting, Marissa Penna-Martinez, Gesine Meyer, Heinrich Kahles, Klaus Badenhoop, Stephanie Hahner, Marcus Quinkler, Alberto Falorni, Amanda Phipps-Green, Tony R Merriman, William Ollier, Heather J Cordell, Dag Undlien, Barbara Czarnocka, Eystein Husebye, Simon H S Pearce
Publikováno v:
PLoS ONE, Vol 9, Iss 3, p e88991 (2014)
BackgroundGene variants known to contribute to Autoimmune Addison's disease (AAD) susceptibility include those at the MHC, MICA, CIITA, CTLA4, PTPN22, CYP27B1, NLRP-1 and CD274 loci. The majority of the genetic component to disease susceptibility has
Externí odkaz:
https://doaj.org/article/cf7215e2cefb44d48df2b282f625b2c9