Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Amanda P. Henry"'
Publikováno v:
Egyptian Journal of Medical Human Genetics, Vol 22, Iss 1, Pp 1-7 (2021)
Abstract Background Genetic variation has a key role in the development of asthma, but genetic influences may vary between different populations. In this study, we looked for evidence of association of key asthma SNPs, namely, rs1420101 and rs1019215
Externí odkaz:
https://doaj.org/article/9b15df517e014722b18bdd8aba0df0f3
Autor:
Amanda P. Henry, Kelly Probert, Ceri E. Stewart, Dhruma Thakker, Sangita Bhaker, Sheyda Azimi, Ian P. Hall, Ian Sayers
Publikováno v:
Respiratory Research, Vol 20, Iss 1, Pp 1-14 (2019)
Abstract Genome wide association (GWA) studies have reproducibly identified signals on chromosome 4q24 associated with lung function and COPD. GSTCD (Glutathione S-transferase C-terminal domain containing) represents a candidate causal gene in this l
Externí odkaz:
https://doaj.org/article/45b95aff7d3b48fb89b56781600c8437
Publikováno v:
eLife, Vol 9 (2020)
The human subcortex is comprised of more than 450 individual nuclei which lie deep in the brain. Due to their small size and close proximity, up until now only 7% have been depicted in standard MRI atlases. Thus, the human subcortex can largely be co
Externí odkaz:
https://doaj.org/article/632d2bfc666540f3847ca8ff29c4120f
Autor:
Sangita Bhaker, Michael A. Portelli, Robert J. Hall, David O. Bates, Ian Sayers, Vincent Pang, Amanda P. Henry, Tyson V. Sharp, Jonathan O'Loughlin
Publikováno v:
ERJ Open Research
article-version (VoR) Version of Record
ERJ Open Research, Vol 7, Iss 1 (2021)
article-version (VoR) Version of Record
ERJ Open Research, Vol 7, Iss 1 (2021)
Genetic studies have identified several epithelial-derived genes associated with airway diseases. However, techniques used to study gene function frequently exceed the proliferative potential of primary human bronchial epithelial cells (HBECs) isolat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53953e0e0f992d83fd7833e8a371fb54
https://doi.org/10.1183/23120541.00254-2020
https://doi.org/10.1183/23120541.00254-2020
Autor:
David O. Bates, Vincent Pang, Judith M. Vonk, Charlote K. Billington, John W. Holloway, Sangita Bhaker, Cornelis J. Vermeulen, Don D. Sin, Ian Sayers, Martin D. Tobin, Peter H. Howarth, F. Nicole Dijk, David C. Nickle, Ian P. Hall, Yohan Bossé, Louise V. Wain, Dominick E. Shaw, John D Blakey, Andrew M. Fogarty, Amisha Singapuri, Michael A. Portelli, Martijn C. Nawijn, Cheng J. Xu, Andrew V. Benest, Ma'en Obeidat, Liam G Heaney, Jenny Hankinson, Maarten van den Berge, Rekha Chaudhuri, Angela Simpson, Tricia M. McKeever, Simon R. Johnson, Adel H. Mansur, Robert Niven, Zara Pogson, Gabrielle A. Lockett, Christopher E. Brightling, Amanda P. Henry, Neil C. Thomson, Nick Shrine, Gerard H. Koppelman, Maria Ketelaar, Alen Faiz
Publikováno v:
Journal of Allergy and Clinical Immunology, 147(1), 144-157. MOSBY-ELSEVIER
Background: Asthma is a complex disease with multiple phenotypes that may differ in disease pathobiology and treatment response. IL33 single nucleotide polymorphisms (SNPs) have been reproducibly associated with asthma. IL33 levels are elevated in sp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc2e19b5c3a77f7d0087040f985a7c81
https://doi.org/10.1016/j.jaci.2020.04.051
https://doi.org/10.1016/j.jaci.2020.04.051
Autor:
Siva Praveen Puppala, Amanda P. Henry, Binaya Kc, Dhruma Thakker, Ian P. Hall, Charlotte K. Billington, Ian Sayers, Parth Sarathi Mahapatra
Publikováno v:
Annals of the American Thoracic Society. 17:688-698
Rationale: Exposure to biomass smoke is believed to increase the risk of developing chronic obstructive pulmonary disease. However, little is known about the mechanisms underlying responses to biom...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::27c40cd891ea3736e2e87cf9053328e4
https://doi.org/10.1513/annalsats.201911-827oc
https://doi.org/10.1513/annalsats.201911-827oc
Publikováno v:
Egyptian Journal of Medical Human Genetics, Vol 22, Iss 1, Pp 1-7 (2021)
Background Genetic variation has a key role in the development of asthma, but genetic influences may vary between different populations. In this study, we looked for evidence of association of key asthma SNPs, namely, rs1420101 and rs10192157 within
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a68ba804f7a930b6a09ea618b9b486d4
https://doi.org/10.1186/s43042-021-00163-y
https://doi.org/10.1186/s43042-021-00163-y
Autor:
D. Thakker, P. Sarathi Mahapatra, Ian P. Hall, Binaya Kc, Bim Prasad Shrestha, Siva Praveen Puppala, Amanda P. Henry, Charlotte K. Billington
Publikováno v:
ISEE Conference Abstracts. 2020
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::22760aaf5efe1c13e648821567c345d8
https://doi.org/10.1289/isee.2020.virtual.p-1198
https://doi.org/10.1289/isee.2020.virtual.p-1198
Extended Lifespan Bronchial Epithelial Cells Maintain Cellular Phenotype and Transcriptome Integrity
Autor:
Sangita Bhaker, David O. Bates, Tyson V. Sharp, Michael A. Portelli, Amanda P. Henry, Vincent Pang, Robert J. Hall, J. O'Loughlin, Ian Sayers
Publikováno v:
A65. EPITHELIAL CELL BIOLOGY: THE PLOT THICKENS.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::108ff38396a8b88cc3fa15edbcca4938
https://doi.org/10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a2298
https://doi.org/10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a2298
Autor:
Charlotte K. Billington, Gerard H. Koppelman, Liam G Heaney, Adel H. Mansur, Jenny Hankinson, Martijn C. Nawijn, Corry-Anke Brandsma, Sangita Bhaker, Andrew M. Fogarty, Dominick E. Shaw, Michael A. Portelli, Cornelis J. Vermeulen, Judith M. Vonk, Nick Shrine, Amanda P. Henry, Ian Sayers, Yohan Bossé, Maria Ketelaar, Martin D. Tobin, Peter H. Howarth, David C. Nickle, Néomi S. Grotenboer, Ma'en Obeidat, Gabrielle A. Lockett, John W. Holloway, Christopher E. Brightling, Alen Faiz, Rekha Chaudhuri, Tricia M. McKeever, Simon R. Johnson, Paul de Vos, Dirkje S. Postma, Zara Pogson, Neil C. Thomson, Sharon Brouwer, Maarten van den Berge, Angela Simpson, Amisha Singapuri, Robert Niven, F. Nicole Dijk, Ian P. Hall, Louise V. Wain, John D Blakey
Publikováno v:
Portelli, M A, Dijk, F N, Ketelaar, M E, Shrine, N, Hankinson, J, Bhaker, S, Grotenboer, N S, Obeidat, M, Henry, A P, Billington, C K, Shaw, D, Johnson, S R, Pogson, Z E, Fogarty, A, McKeever, T M, Nickle, D C, Bossé, Y, van den Berge, M, Faiz, A, Brouwer, S, Vonk, J M, de Vos, P, Brandsma, C-A, Vermeulen, C J, Singapuri, A, Heaney, L G, Mansur, A H, Chaudhuri, R, Thomson, N C, Holloway, J W, Lockett, G A, Howarth, P H, Niven, R, Simpson, A, Blakey, J D, Tobin, M D, Postma, D S, Hall, I P, Wain, L V, Nawijn, M C, Brightling, C E, Koppelman, G H & Sayers, I 2020, ' Phenotypic and functional translation of IL1RL1 locus polymorphisms in lung tissue and asthmatic airway epithelium ', JCI insight, vol. 5, no. 8, pp. 1-19 . https://doi.org/10.1172/jci.insight.132446
JCI Insight
JCI Insight, 5(8):132446. AMER SOC CLINICAL INVESTIGATION INC
JCI Insight
JCI Insight, 5(8):132446. AMER SOC CLINICAL INVESTIGATION INC
The IL1RL1 (ST2) gene locus is robustly associated with asthma; however, the contribution of single nucleotide polymorphisms (SNPs) in this locus to specific asthma subtypes and the functional mechanisms underlying these associations remain to be def
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35eec0d3bd47361ef723e102569f7099
https://doi.org/10.1172/jci.insight.132446
https://doi.org/10.1172/jci.insight.132446