Výsledky vyhledávání - "Amanda P. Cline"

Mutation of a barrier insulator in the human ankyrin-1 gene is associated with hereditary spherocytosis

Autor: Robert I. Liem, Nancy E. Seidel, David M. Bodine, Laurie A. Steiner, Patrick G. Gallagher, Ashley N. Owen, Lisa Garrett, Amanda P. Cline

Publikováno v: Journal of Clinical Investigation. 120:4453-4465

Defects of the ankyrin-1 gene are the most common cause in humans of hereditary spherocytosis, an inherited anemia that affects patients of all ethnic groups. In some kindreds, linked -108/-153 nucleotide substitutions have been found in the upstream

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6dcc760db5eb8f0fb5d85bdcdb02db40
https://doi.org/10.1172/jci42240

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An 11-amino acid β-hairpin loop in the cytoplasmic domain of band 3 is responsible for ankyrin binding in mouse erythrocytes

Autor: Philip S. Low, Erin M. Parry, Lisa Garrett-Beal, Amanda P. Cline, Nicholas O. Markham, Patrick G. Gallagher, Marko Stefanovic, David M. Bodine

Publikováno v: Proceedings of the National Academy of Sciences. 104:13972-13977

The best-studied cytoskeletal system is the inner surface of the erythrocyte membrane, which provides an erythrocyte with the structural support needed to be stable yet flexible as it passes through the circulation. Current structural models predict

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b007d9ce95245d80a3dba136506a286b
https://doi.org/10.1073/pnas.0706266104

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Development of a Stable Retrovirus Vector Capable of Long-Term Expression of γ-Globin mRNA in Mouse Erythrocytes

Autor: Denise E. Sabatino, Patrick G. Gallagher, Stacie M. Anderson, David M. Bodine, Amanda P. Cline, Nancy E. Seidel

Publikováno v: Annals of the New York Academy of Sciences. 938:246-261

Gene therapy for patients with hemoglobin disorders such has been hampered by the inability of retrovirus vectors to transfer globin genes and the locus control region (LCR) into hematopoietic stem cells without rearrangement. In addition, the expres

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5dc3ecd03daa2bd6120a08e8bff73d75
https://doi.org/10.1111/j.1749-6632.2001.tb03595.x

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Hmgb3: an HMG-box family member expressed in primitive hematopoietic cells that inhibits myeloid and B-cell differentiation

Autor: Nancy E. Seidel, David J. Curtis, David M. Bodine, Michael J. Nemeth, Martha Kirby, Amanda P. Cline, Lisa Garrett-Beal

Publikováno v: Blood. 102:1298-1306

Hmgb3 is a member of a family of chromatin-binding proteins that can alter DNA structure to facilitate transcription factor binding. We identified the Hmgb3 cDNA in a subtractive hybridization screen for transcripts that are preferentially expressed

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::318ae639d6250b31ecd76ba5def64499
https://doi.org/10.1182/blood-2002-11-3541

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Erythrocyte Ankyrin Promoter Mutations Associated with Recessive Hereditary Spherocytosis Cause Significant Abnormalities in Ankyrin Expression

Autor: Douglas M. Nilson, Amanda P. Cline, David M. Bodine, Patrick G. Gallagher, Clara Wong, Lisa Garrett, Daniela S. Basseres, Denise E. Sabatino

Publikováno v: Journal of Biological Chemistry. 276:41683-41689

Ankyrin defects are the most common cause of hereditary spherocytosis (HS). In several kindreds with recessive, ankyrin-deficient HS, mutations have been identified in the ankyrin promoter that have been proposed to decrease ankyrin synthesis. We ana

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efda6e296bcddb1431a9c61523dd05c5
https://doi.org/10.1074/jbc.m105844200

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Isolation of Stem Cell-Specific cDNAs from Hematopoietic Stem Cell Populations

Autor: Donald Orlic, Amanda P. Cline, Shari L. Laprise, David M. Bodine, Stacie M. Anderson

Publikováno v: Annals of the New York Academy of Sciences. 872:243-255

We have begun to isolate gene sequences that are specifically expressed in hematopoietic stem cells (HSCs). There are at least three fundamental requirements for the isolation of HSC-specific transcripts. First, highly enriched populations of HSCs, a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8f3414c3eeef6fef04972c9cd18d7f7
https://doi.org/10.1111/j.1749-6632.1999.tb08469.x

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A Human β-Spectrin Gene Promoter Directs High Level Expression in Erythroid but Not Muscle or Neural Cells

Autor: Denise E. Sabatino, Amanda P. Cline, Bernard G. Forget, Patrick G. Gallagher, David M. Bodine, Marc Romana, Lisa Garrett

Publikováno v: Journal of Biological Chemistry. 274:6062-6073

beta-Spectrin is an erythrocyte membrane protein that is defective in many patients with abnormalities of red blood cell shape including hereditary spherocytosis and elliptocytosis. It is expressed not only in erythroid tissues but also in muscle and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06cef07b9b1712e213524dddbc61f87d
https://doi.org/10.1074/jbc.274.10.6062

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Improved retroviral gene transfer into murine and Rhesus peripheral blood or bone marrow repopulating cells primed in vivo with stem cell factor and granulocyte colony-stimulating factor

Autor: Nancy E. Seidel, Sandra Doren, David M. Bodine, Stephanie L. Sellers, Amanda P. Cline, Mark E. Metzger, Brian A. Agricola, Cynthia E. Dunbar, Robert E. Donahue

Publikováno v: Proceedings of the National Academy of Sciences. 93:11871-11876

In previous studies we showed that 5 days of treatment with granulocyte colony-stimulating factor (G-CSF) and stem cell factor (SCF) mobilized murine repopulating cells to the peripheral blood (PB) and that these cells could be efficiently transduced

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::862c9dc9d232d75285e81298393b2ef0
https://doi.org/10.1073/pnas.93.21.11871

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The level of mRNA encoding the amphotropic retrovirus receptor in mouse and human hematopoietic stem cells is low and correlates with the efficiency of retrovirus transduction

Autor: Amanda P. Cline, Laurie J. Girard, Donald Orlic, David M. Bodine, Stacie M. Anderson, Craig T. Jordan

Publikováno v: Proceedings of the National Academy of Sciences. 93:11097-11102

The low level of amphotropic retrovirus-mediated gene transfer into human hematopoietic stem cells (HSC) has been a major impediment to gene therapy for hematopoietic diseases. In the present study, we have examined amphotropic retrovirus receptor (a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12eabaf26e567d92be2fa8b993ed7f0c
https://doi.org/10.1073/pnas.93.20.11097

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A tissue-specific chromatin loop activates the erythroid ankyrin-1 promoter

Autor: Clara Wong, Emily D. Rout, Jolinta Y. Lin, David M. Bodine, Laurie A. Steiner, Patrick G. Gallagher, Lisa Garrett, Ashley O. Yocum, Nancy E. Seidel, Amanda P. Cline

Publikováno v: Blood. 120(17)

The human ankyrin-1 gene (ANK1) contains 3 tissue-specific alternative promoters. We have shown previously that the erythroid-specific ankyrin 1 (ANK1E) core promoter contains a 5′ DNase I hypersensitive site (HS) with barrier insulator function th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::180609e71960f4cabc4afd526d2de2ff
https://pubmed.ncbi.nlm.nih.gov/22968456

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