Zobrazeno 1 - 10
of 62
pro vyhledávání: '"Amanda P Beck"'
Autor:
Caroline J Zeiss, Dongwook Shin, Brent Vander Wyk, Amanda P Beck, Natalie Zatz, Charles A Sneiderman, Halil Kilicoglu
Publikováno v:
PLoS ONE, Vol 14, Iss 12, p e0226176 (2019)
Discovery studies in animals constitute a cornerstone of biomedical research, but suffer from lack of generalizability to human populations. We propose that large-scale interrogation of these data could reveal patterns of animal use that could narrow
Externí odkaz:
https://doaj.org/article/9acee538d5c14322a734af1b2c79e878
Publikováno v:
PLoS ONE, Vol 12, Iss 2, p e0171790 (2017)
Translation of disease-modifying therapies in neurodegenerative disease has been disappointing. Parkinson's disease (PD) was used to compare patterns of preclinical study design for symptomatic and potentially disease-modifying interventions. We exam
Externí odkaz:
https://doaj.org/article/94a1b88bad8a4e3d9c03f91a058d8e10
Publikováno v:
PLoS ONE, Vol 12, Iss 5, p e0175874 (2017)
The contribution of 5α-reductase 1 and 5α-reductase 2 to prostate cancer development and progression is not clearly understood. TRAMP mice are a common prostate cancer model, in which 5α-reductase 1 and 5α-reductase 2 expression levels, along wit
Externí odkaz:
https://doaj.org/article/8a9adad6192d4afdaa250951107d24f8
Autor:
Alexander B Opoku-Acheampong, Dave Unis, Jamie N Henningson, Amanda P Beck, Brian L Lindshield
Publikováno v:
PLoS ONE, Vol 8, Iss 10, p e77738 (2013)
BACKGROUND:The prostate cancer prevention trial (PCPT) and Reduction by dutasteride of Prostate Cancer Events (REDUCE) trial found that 5α-reductase (5αR) inhibitors finasteride and dutasteride respectively, decreased prostate cancer prevalence but
Externí odkaz:
https://doaj.org/article/11e48aed8378495784101b9e57f81617
Autor:
Elayna M. Shanker, Amanda P. Beck
Publikováno v:
Journal of Comparative Pathology. 203:26-30
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6cc77c71a5494a1f8adc966e30428472
https://doi.org/10.1016/j.jcpa.2023.04.005
https://doi.org/10.1016/j.jcpa.2023.04.005
Autor:
Elena, Tosti, Ana S, Almeida, Tam T T, Tran, Mariel, Barbachan E Silva, Pilib Ó, Broin, Robert, Dubin, Ken, Chen, Amanda P, Beck, Andrew S, Mclellan, Eduardo, Vilar, Aaron, Golden, Paul W, O'Toole, Winfried, Edelmann
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology. 14:693-717
Mutations in DNA mismatch repair (MMR) genes are causative in Lynch syndrome and a significant proportion of sporadic colorectal cancers (CRCs). MMR-deficient (dMMR) CRCs display increased mutation rates, with mutations frequently accumulating at sho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe7b1fbe4bea68d03347796ae08679a4
https://doi.org/10.1016/j.jcmgh.2022.05.010
https://doi.org/10.1016/j.jcmgh.2022.05.010
Autor:
Timothy K Cooper, David K Meyerholz, Amanda P Beck, Martha A Delaney, Alessandra Piersigilli, Teresa L Southard, Cory F Brayton
Publikováno v:
ILAR J
Animals are valuable resources in biomedical research in investigations of biological processes, disease pathogenesis, therapeutic interventions, safety, toxicity, and carcinogenicity. Interpretation of data from animals requires knowledge not only o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b42c620a070dc4f5b1a42a49fb00ed0d
https://doi.org/10.1093/ilar/ilab022
https://doi.org/10.1093/ilar/ilab022
Autor:
Tania Carvalho, Alessandra Piersigilli, Jerrold M. Ward, Hannah M Atkins, David K. Meyerholz, Hibret A. Adissu, Amanda P. Beck, Daniel R. Rissi
Publikováno v:
Veterinary Pathology. 58:650-654
Veterinary pathologists are key contributors to multidisciplinary biomedical research. However, they are occasionally excluded from authorship in published articles despite their substantial intellectual and data contributions. To better understand t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74361ef3ed433dfc0cf1c7a44cafa5eb
https://doi.org/10.1177/03009858211011943
https://doi.org/10.1177/03009858211011943
Publikováno v:
Veterinary Pathology. 58:258-265
Animal models have critical roles in biomedical research in promoting understanding of human disease and facilitating development of new therapies and diagnostic techniques to improve human and animal health. In the study of myriad human conditions,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65cddd2f1feec6678b0bf28cf3b7c788
https://doi.org/10.1177/0300985820974005
https://doi.org/10.1177/0300985820974005
Autor:
David K. Meyerholz, Amanda P. Beck
Publikováno v:
Cell and Tissue Research. 380:305-311
Animal models are a significant component of biomedical research and play an important role in translational studies. Traditionally, rodent models have been the mainstay and principal choice of researchers but in recent years, there have been signifi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ffa873a1f6a64473b98689a71f8fa66
https://doi.org/10.1007/s00441-019-03134-3
https://doi.org/10.1007/s00441-019-03134-3