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of 14
pro vyhledávání: '"Amanda Oakie"'
Autor:
Frankie Poon, Rangarajan Sambathkumar, Roman Korytnikov, Yasaman Aghazadeh, Amanda Oakie, Paraish S. Misra, Farida Sarangi, M. Cristina Nostro
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Human pluripotent stem cells (hPSCs) have the potential to differentiate into various cell types, including pancreatic insulin-producing β cells, which are crucial for developing therapies for diabetes. However, current methods for directin
Externí odkaz:
https://doaj.org/article/b2d31948ebb349da82cf4f65be091a35
Autor:
Amanda Oakie, Maria Cristina Nostro
Publikováno v:
Frontiers in Endocrinology, Vol 12 (2021)
Restoring the number of glucose-responsive β-cells in patients living with diabetes is critical for achieving normoglycemia since functional β-cells are lost during the progression of both type 1 and 2 diabetes. Stem cell-derived β-cell replacemen
Externí odkaz:
https://doaj.org/article/9de1a90102af4a4c8b50d1ad18692dd9
Publikováno v:
Cell and Tissue Research. 381:163-175
The β1 integrin subunit contributes to pancreatic beta cell growth and function through communication with the extracellular matrix (ECM). The effects of in vitro and in vivo β1 integrin knockout have been extensively studied in mature islets, yet
Publikováno v:
Stem Cells and Development. 27:275-286
The enzyme aldehyde dehydrogenase (ALDH) is found in developing and multipotent cell populations, and is important for the production and regulation of retinoic acid, which controls β-cell differentiation in the pancreas. The role of ALDH-expressing
Publikováno v:
Paediatrics Publications
Aims/hypothesis: c-Kit signalling regulates intracellular pathways that enhance beta cell proliferation, insulin secretion and islet vascularisation in mice up to 28 weeks of age and on short-term high-fat diet. However, long-term c-Kit activation in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f8964b2aaf6b394f0b81d8478d9c62c
https://ir.lib.uwo.ca/paedpub/2152
https://ir.lib.uwo.ca/paedpub/2152
Publikováno v:
Molecular and cellular endocrinology. 499
The presence of insulin receptor (IR) on insulin-secreting beta cells suggests an autocrine regulatory role for insulin in its own signalling. Congenital beta cell-specific IR knockout (βIRKO) mouse studies have demonstrated the development of age-d
Publikováno v:
Oncotarget
Paediatrics Publications
Paediatrics Publications
// Mark Trinder 1,2,* , Liangyi Zhou 1,3,* , Amanda Oakie 1,3 , Matthew Riopel 1 and Rennian Wang 1,2,4 1 Children’s Health Research Institute, London, Ontario, Canada 2 Departments of Physiology & Pharmacology, University of Western Ontario, Londo
Autor:
Amanda Oakie, Rennian Wang
Publikováno v:
Paediatrics Publications
Insulin secretion from pancreatic β-cells is initiated through channel-mediated depolarization, cytoskeletal remodeling, and vesicle tethering at the cell membrane, all of which can be regulated through cell surface receptors. Receptor tyrosine kina
Publikováno v:
Stem cells and development. 27(4)
The enzyme aldehyde dehydrogenase (ALDH) is found in developing and multipotent cell populations, and is important for the production and regulation of retinoic acid, which controls β-cell differentiation in the pancreas. The role of ALDH-expressing
Autor:
Amanda Oakie
Publikováno v:
University of Western Ontario Medical Journal. 87:3
87(S) editorial