Výsledky vyhledávání - "Amanda Nordigården"

Coexpression of hyperactivated AKT1 with additional genes activated in leukemia drives hematopoietic progenitor cells to cell cycle block and apoptosis

Autor: Yanjuan Tang, Josefine Åhsberg, Camilla Halvarsson, Wan Man Wong, Jan-Ingvar Jönsson, Amanda Nordigården, Emma Rörby, Komal Kumar

Publikováno v: Experimental Hematology. 43:554-564

The phosphatidylinositol 3-kinase/AKT pathway is an integral component of signaling involved in the development of many cancers, including myeloid leukemias such as chronic myeloid leukemia and acute myeloid leukemia (AML). Increased AKT1 activity is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78856ce9ef5c5eaf41dc4a4c175b8ff9
https://doi.org/10.1016/j.exphem.2015.04.007

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BH3-only protein Bim more critical than Puma in tyrosine kinase inhibitor–induced apoptosis of human leukemic cells and transduced hematopoietic progenitors carrying oncogenic FLT3

Autor: Andreas Villunger, Maria Kraft, Verena Labi, Amanda Nordigården, Eric Lam, Pernilla Eliasson, Jan-Ingvar Jönsson

Publikováno v: Blood. 113:2302-2311

Constitutively activating internal tandem duplications (ITD) of FLT3 (FMS-like tyrosine kinase 3) are the most common mutations in acute myeloid leukemia (AML) and correlate with poor prognosis. Receptor tyrosine kinase inhibitors targeting FLT3 have

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f3044091c9a3e8d8d16b21b21d6a369
https://doi.org/10.1182/blood-2008-07-167023

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Lysozyme Amyloidogenesis Is Accelerated by Specific Nicking and Fragmentation but Decelerated by Intact Protein Binding and Conversion

Autor: Sofie Nyström, Karin Sörgjerd, Amanda Nordigården, Per Hammarström, Rajesh Mishra, Yen-Chi Yu

Publikováno v: Journal of Molecular Biology. 366:1029-1044

We have revisited the well-studied heat and acidic amyloid fibril formation pathway (pH 1.6, 65 degrees C) of hen egg-white lysozyme (HEWL) to map the barriers of the misfolding and amyloidogenesis pathways. A comprehensive kinetic mechanism is prese

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04ada4b8c3b881405078563ffbf5a901
https://doi.org/10.1016/j.jmb.2006.11.084

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Irreversible pan-ERBB inhibitor canertinib elicits anti-leukaemic effects and induces the regression of FLT3-ITD transformed cells in mice

Autor: Amanda, Nordigården, Jenny, Zetterblad, Cecilia, Trinks, Henrik, Gréen, Pernilla, Eliasson, Pia, Druid, Kourosh, Lotfi, Lars, Rönnstrand, Thomas M, Walz, Jan-Ingvar, Jönsson

Publikováno v: British journal of haematology. 155(2)

Recent findings have indicated that tyrosine kinase inhibitors (TKIs) targeting the ERBB receptor family display anti-leukaemic effects, despite the lack of receptor expression on human leukaemic cells. The occurrence of activating mutations in the g

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ae1f2b3ec42e4e2db3c6ed70985e5989
https://pubmed.ncbi.nlm.nih.gov/21848891

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Bcl11bmutations identified in murine lymphomas increase the proliferation rate of hematopoietic progenitor cells

Autor: Anneli Karlsson, Peter Söderkvist, Jan-Ingvar Jönsson, Amanda Nordigården

Publikováno v: BMC Cancer, Vol 7, Iss 1, p 195 (2007)
BMC Cancer

Background The telomeric region of mouse chromosome 12 has previously shown frequent allelic loss in murine lymphoma. The Bcl11b gene has been identified and suggested as a candidate tumor suppressor gene within this region. In this study, we aimed t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1490075d6d52ec81324ef009d9c2069

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