Oral and intravenous pharmacokinetics of metformin with and without oral codeine intake in healthy subjects - a cross-over study

Autor: Amanda Nøddebo Nyrup, Ida Kuhlmann, Kim Brøsen, Flemming Nielsen, Kurt Højlund, Per Damkier, Troels K Bergmann, Tore Bjerregaard Stage, Mette Marie Hougaard Christensen

Publikováno v: Kuhlmann, I, Nyrup, A N, Stage, T B, Christensen, M M H, Bergmann, T K, Damkier, P, Nielsen, F, Højlund, K & Brøsen, K 2021, ' Oral and intravenous pharmacokinetics of metformin with and without oral codeine intake in healthy subjects-a cross-over study ', Clinical and Translational Science, vol. 14, no. 6, pp. 2408-2419 . https://doi.org/10.1111/cts.13107
Clinical and Translational Science
Clinical and Translational Science, Vol 14, Iss 6, Pp 2408-2419 (2021)

The aim of the study was to investigate if there is a clinically relevant drug interaction between metformin and codeine. Volunteers were randomized to receive on four separate occasions: (A) orally administered metformin (1 g), (B) intravenously adm

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https://findresearcher.sdu.dk:8443/ws/files/194645421/cts.13107.pdf