Shugoshin-1 Balances Aurora B Kinase Activity via PP2A to Promote Chromosome Bi-orientation

Autor: Amanda Meppelink, Lilian Kabeche, Martijn J.M. Vromans, Duane A. Compton, Susanne M.A. Lens

Publikováno v: Cell Reports, Vol 11, Iss 4, Pp 508-515 (2015)

Correction of faulty kinetochore-microtubule attachments is essential for faithful chromosome segregation and dictated by the opposing activities of Aurora B kinase and PP1 and PP2A phosphatases. How kinase and phosphatase activities are appropriatel

Externí odkaz: https://doaj.org/article/d31b4d3a59584aeab3fadca88b951887

Mechanistic basis for Sgo1-mediated centromere localization and function of the CPC

Autor: Maria Alba Abad, Tanmay Gupta, Michael A. Hadders, Amanda Meppelink, J. Pepijn Wopken, Elizabeth Blackburn, Juan Zou, Anjitha Gireesh, Lana Buzuk, David A. Kelly, Toni McHugh, Juri Rappsilber, Susanne M.A. Lens, A. Arockia Jeyaprakash

Publikováno v: Abad, M A, Gupta, T, Hadders, M A, Meppelink, A, Wopken, J P, Blackburn, E, Zou, J, Gireesh, A, Buzuk, L, Kelly, D A, Mchugh, T, Rappsilber, J, Lens, S M A & Jeyaprakash, A A 2022, ' Mechanistic basis for Sgo1-mediated centromere localization and function of the CPC ', Journal of Cell Biology, vol. 221, no. 8, e202108156 . https://doi.org/10.1083/jcb.202108156

Centromere association of the chromosomal passenger complex (CPC; Borealin-Survivin-INCENP-Aurora B) and Sgo1 is crucial for chromosome biorientation, a process essential for error-free chromosome segregation. Phosphorylated histone H3 Thr3 (H3T3ph;

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5ae4c5c79dc9b650c4f811ebf002969
https://hdl.handle.net/20.500.11820/cf915011-2082-4fe9-9947-a47297790207

Aurora A kinase phosphorylates Hec1 to regulate metaphase kinetochore-microtubule dynamics

Autor: Sibel Pektas, Olve B. Peersen, Amanda Meppelink, Jennifer G. DeLuca, Susanne M.A. Lens, Amanda J. Broad, Keith F. DeLuca, Jeanne E. Mick

Publikováno v: The Journal of Cell Biology
Journal of Cell Biology, 217(1), 163. Rockefeller University Press

Precise regulation of kinetochore–microtubule attachments is essential for successful chromosome segregation. DeLuca et al. show that Aurora A kinase regulates kinetochore–microtubule dynamics of metaphase chromosomes through phosphorylation of H

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6476ecdc42cb7375048afb8cb22286b3
https://pubmed.ncbi.nlm.nih.gov/29187526

Tdrd1 acts as a molecular scaffold for Piwi proteins and piRNA targets in zebrafish

Autor: René F. Ketting, Jeroen Krijgsveld, Boudewijn M.T. Burgering, Stefan Redl, Eugene Berezikov, Harmjan R. Vos, Hsin Yi Huang, Saskia Houwing, Amanda Meppelink, Peter Ladurner, Lucas J.T. Kaaij, Cecilia B. Moens, Bruce W. Draper, Sharon Gauci

Publikováno v: The EMBO Journal. 30:3298-3308

Piwi proteins function in an RNAi-like pathway that silences transposons. Piwi-associated RNAs, also known as piRNAs, act as a guide to identify Piwi targets. The tudor domain-containing protein Tdrd1 has been linked to this pathway but its function

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::72a9c91e484ed6568ab525a092abf479
https://doi.org/10.1038/emboj.2011.228

Tdrd1 acts as a molecular scaffold for Piwi proteins and piRNA targets in zebrafish

Autor: Hsin-Yi, Huang, Saskia, Houwing, Lucas J T, Kaaij, Amanda, Meppelink, Stefan, Redl, Sharon, Gauci, Harmjan, Vos, Bruce W, Draper, Cecilia B, Moens, Boudewijn M, Burgering, Peter, Ladurner, Jeroen, Krijgsveld, Eugene, Berezikov, René F, Ketting

Publikováno v: The EMBO journal. 30(16)

Piwi proteins function in an RNAi-like pathway that silences transposons. Piwi-associated RNAs, also known as piRNAs, act as a guide to identify Piwi targets. The tudor domain-containing protein Tdrd1 has been linked to this pathway but its function

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::90bbb291065dea936666891c29cc60e7
https://pubmed.ncbi.nlm.nih.gov/21743441