Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Amanda MacPherson"'
Autor:
Daniel M. Benjamin, Spencer P. Hey, Amanda MacPherson, Yasmina Hachem, Kara S. Smith, Sean X. Zhang, Sandy Wong, Samantha Dolter, David R. Mandel, Jonathan Kimmelman
Publikováno v:
PLoS ONE, Vol 17, Iss 2 (2022)
Objective To assess the accuracy of principal investigators’ (PIs) predictions about three events for their own clinical trials: positivity on trial primary outcomes, successful recruitment and timely trial completion. Study design and setting A sh
Externí odkaz:
https://doaj.org/article/f85da0face844a239b35e51d2705b1d6
Autor:
Patrick Bodilly Kane, Hannah Moyer, Amanda MacPherson, Jesse Papenburg, Brian J. Ward, Stephen B. Broomell, Jonathan Kimmleman
Publikováno v:
PLoS ONE, Vol 17, Iss 2 (2022)
Objectives Compare lay expectations of medical development to those of experts in the context of SARS-CoV-2 vaccine development. Methods A short online survey of experts and lay people measuring when participants believe important vaccine milestones
Externí odkaz:
https://doaj.org/article/a6b12988de1940f4be4e4611493e21b5
Autor:
Amanda MacPherson, Elias Gumnit, Charlotte Ouimet, Nora Hutchinson, Karl Kieburtz, Toni S. Pearson, Jonathan Kimmelman
Publikováno v:
Neurotherapeutics. 19:1507-1513
While the drug development literature provides numerous estimates of the financial costs to bring a new drug to market, the investment of patient-participants in the research process has not been described. Trial participants and their caregivers, li
Autor:
Nora Hutchinson, Fareed A. Awan, Nicole E. Basta, Emma Feldhake, Charlotte Ouimet, Elisabeth Oliviero, Jonathan Kimmelman, Jacky Sheng, Oliver Schneider, Catherine Wang, Amanda MacPherson, Jesse Papenburg
Publikováno v:
Annals of Internal Medicine
The authors review the timelines, and probabilities, of recent vaccines progressing from phase 2 clinical trials to licensure within 10 years.
Visual Abstract. Probability of Success and Timelines of Vaccines for Viral Infectious Diseases The au
Visual Abstract. Probability of Success and Timelines of Vaccines for Viral Infectious Diseases The au
Autor:
Amanda MacPherson, Hannah Moyer, Stephen B. Broomell, Patrick Bodilly Kane, Jesse Papenburg, Jonathan Kimmelman, Brian J. Ward
Publikováno v:
Journal of General Internal Medicine
Publikováno v:
Neurology
ObjectiveTo determine whether patients randomized to unapproved, disease-modifying interventions in neurodegenerative disease trials have better outcomes than patients randomized to placebo by performing a systematic review and meta-analysis of risk
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b8a4689dc6ee671b1bbdba4b812ed68
https://europepmc.org/articles/PMC7011691/
https://europepmc.org/articles/PMC7011691/
Autor:
Daniel M. Benjamin, Amanda MacPherson, Ulrich Dirnagl, Jonathan Kimmelman, Friedemann Paul, Pavel Atanasov, Andreas Antonios Diamantaras, Esther Vinarov, Ian Shrier
Publikováno v:
Neurology
ObjectiveTo explore the accuracy of combined neurology expert forecasts in predicting primary endpoints for trials.MethodsWe identified one major randomized trial each in stroke, multiple sclerosis (MS), and amyotrophic lateral sclerosis (ALS) that w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc431d33bd07f59ff36be41d56005462
Autor:
C Stanton, Emmanuel Bourinet, Amanda MacPherson, U Khan, A Donoghue, Francina Agosti, Alfredo Ribeiro-da-Silva, C Dietz, Tarheen Fatima, Rikard Blunck, Élise Faure, Noosha Yousefpour, Hugues Petitjean, Marine Christin, Reza Sharif-Naeini, Lou Beaulieu-Laroche, Albena Davidova
SummaryMechanotransduction, the conversion of mechanical stimuli into electrical signals, is a fundamental process underlying several physiological functions such as touch and pain sensing, hearing and proprioception. This process is carried out by s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9020702a9e1db2b787e33c2e4dccabb7
https://hal.archives-ouvertes.fr/hal-02356322/document
https://hal.archives-ouvertes.fr/hal-02356322/document
Autor:
Steven A. Prescott, Reza Sharif-Naeini, Stephanie Mouchbahani-Constance, Albena Davidova, Hugues Petitjean, L. Stephen Lesperance, Amanda MacPherson
Publikováno v:
Pain. 159:2255-2266
The lionfish (Pterois volitans) is a venomous invasive species found in the Caribbean and Northwestern Atlantic. It poses a growing health problem because of the increase in frequency of painful stings, for which no treatment or antidote exists, and
Autor:
Eli Gumnit, Amanda MacPherson, Jonathan Kimmelman, Benjamin Carlisle, Adélaïde Doussau, Nora Hutchinson, Rafia Bosan, Dean Fergusson
Publikováno v:
JAMA Network Open
Key Points Question How many patient study participants are needed to obtain a first US Food and Drug Administration approval for a new anticancer drug or biologic therapy? Findings In this cohort study of 120 drugs and biologic therapies, more than