Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Amanda M. Shearman"'
Autor:
Qiong Yang, Chao-Qiang Lai, Laurence Parnell, L. Adrienne Cupples, Xian Adiconis, Yueping Zhu, Peter W.F. Wilson, David E. Housman, Amanda M. Shearman, Ralph B. D'Agostino, Jose M. Ordovas
Publikováno v:
Journal of Lipid Research, Vol 46, Iss 7, Pp 1416-1425 (2005)
High density lipoprotein cholesterol (HDL-C) is inversely associated with coronary heart disease and has a genetic component; however, linkage to HDL-C is not conclusive. Subfractions of HDL, such as HDL3-C, may be better phenotypes for linkage studi
Externí odkaz:
https://doaj.org/article/4e2476db3d7a4acb8280136da1eb4468
Autor:
Piran Aliabadi, Serkalem Demissie, Amanda M. Shearman, L. Adrienne Cupples, Barton L. Wise, David T. Felson, Mei Yang, David J. Hunter
Publikováno v:
The Journal of Rheumatology. 36:2772-2779
Objective.We examined reported associations between radiographic hand osteoarthritis (OA) and single-nucleotide polymorphisms (SNP) in 2 candidate genes associated with OA in other joints: estrogen receptor alpha (ESR1) and beta (ESR2).Methods.In 539
Autor:
Michael E. Mendelsohn, Amanda M. Shearman, Inga Peter, Emelia J. Benjamin, Richard D. Patten, Richard H. Karas, Gordon S. Huggins, Arthur Pollak, Serkalem Demissie, David E. Housman, Christopher H. Schmid, L. Adrienne Cupples, Ramachandran S. Vasan
Publikováno v:
Hypertension. 49:1000-1006
Left ventricular (LV) mass and other LV measures have been shown to be heritable. In this study we hypothesized that functional variation in the gene coding for estrogen receptor-α ( ESR1 ), known for mediating the effect of estrogens on myocardium,
Autor:
Kristen M. Gruenthal, Christopher H. Schmid, David E. Housman, Inga Peter, Michael E. Mendelsohn, Serkalem Demissie, Richard H. Karas, Amanda M. Shearman, L. Adrienne Cupples, Jose M. Ordovas
Publikováno v:
Atherosclerosis. 185:210-218
Plasma lipid profile is affected by endogenous estrogen levels and hormone replacement therapy (HRT). As plasma lipid concentrations have a significant heritable basis and the effects of both endogenous estrogen and use of HRT are mediated by estroge
Autor:
Amanda M. Shearman, L. Adrienne Cupples, Christopher H. Schmid, David E. Housman, Richard H. Karas, Michael E. Mendelsohn, Inga Peter, Deborah R. Zucker, Emelia J. Benjamin, Serkalem Demissie, Jeffrey T. Kuvin, Ramachandran S. Vasan
Publikováno v:
American Journal of Hypertension. 18:1388-1395
Background Left ventricular (LV) hypertrophy is a significant risk factor for cardiovascular disease. Given sex-based differences in cardiac structure and remodeling, we hypothesized that variation in estrogen pathway genes might be associated with a
Autor:
Michael E. Mendelsohn, L. Adrienne Cupples, Serkalem Demissie, Jose M. Ordovas, Christopher H. Schmid, David E. Housman, Amanda M. Shearman, Inga Peter
Publikováno v:
Human Molecular Genetics. 14:2405-2413
High levels of small low density lipoprotein (LDL) particles are a major risk factor for cardiovascular morbidity and mortality. Both estrogens and smoking, with known anti-estrogenic effects, alter the atherogenic lipid profile. We tested for a role
Autor:
Xian Adiconis, Amanda M. Shearman, Chao-Qiang Lai, Peter W.F. Wilson, Jose M. Ordovas, David E. Housman, L. Adrienne Cupples, Yueping Zhu, Laurence D. Parnell, Qiong Yang, Ralph B. D'Agostino
Publikováno v:
Journal of Lipid Research, Vol 46, Iss 7, Pp 1416-1425 (2005)
High density lipoprotein cholesterol (HDL-C) is inversely associated with coronary heart disease and has a genetic component; however, linkage to HDL-C is not conclusive. Subfractions of HDL, such as HDL(3)-C, may be better phenotypes for linkage stu
Autor:
Suat Hayri Ugurbas, Amanda M. Shearman, Elke Denniger, Terho Latvala, Veena Theendakara, R. Scott Winters, Helena Kuivaniemi, Peter White, Sebnem Kargi, Frank Tost, Jennifer Cox, Murat Köksal, M. Krause, Jayne S. Weiss, Wolfram Henn, Gerard Tromp, Maria Hoeltzenbein, Petra Riebeling, Seema Panchal, Timo Tervo
Publikováno v:
Human Genetics. 114:594-600
Schnyder's crystalline corneal dystrophy (SCCD) is a rare autosomal dominant eye disease with a spectrum of clinical manifestations that may include bilateral corneal clouding, arcus lipoides, and anterior corneal crystalline cholesterol deposition.
Autor:
Douglas P. Kiel, Amanda M. Shearman, Kristen M. Gruenthal, L. Adrienne Cupples, David Karasik, Serkalem Demissie, David E. Housman
Publikováno v:
Journal of Bone and Mineral Research. 19:773-781
ESR2 is expressed in bone cells, yet few studies have tested its variation for association with BMD, an important determinant of osteoporotic fractures. This was investigated in 723 men and 795 women from the Framingham study. Results show associatio
Autor:
Daniel Levy, Jackie A. Cooper, David E. Housman, Amanda M. Shearman, L. Adrienne Cupples, Kristin G. Ardlie, Stephanie C. E. Schuit, Paul Kotwinski, Kathryn L. Lunetta, Michael E. Mendelsohn, Barbara Jordan, Kathryn Irenze, Steve E. Humphries, Huibert A. P. Pols, Serkalem Demissie, George J. Miller, André G. Uitterlinden
Publikováno v:
Circulation Research, 98(5), 590-592. Lippincott Williams & Wilkins
Understanding the mechanisms by which estrogens affect cardiovascular disease risk, including the role of variation in the gene for estrogen receptor α ( ESR1 ), may be key to new treatment strategies. We investigated whether the CC genotype at ESR1