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pro vyhledávání: '"Amanda M. Mounce"'
Autor:
Colin G. Barry, Margaret C. Ackley, Michael C. Farmer, Ulrich Bierbach, Amanda M. Mounce, Marcus W. Wright, Susan J. Berners-Price, Cynthia S. Day, Suzanne M. Hess, Beth-Erin Springer
Publikováno v:
JBIC Journal of Biological Inorganic Chemistry. 9:453-461
The synthesis, cytotoxicity, and nucleoside binding of some platinum-acridinylthiourea conjugates derived from the prototypical compound [PtCl(en)(ACRAMTU)](NO3)2 ("PT-ACRAMTU"; en=ethane-1,2-diamine, ACRAMTU=1-[2-(acridin-9-ylamino)ethyl]-1,3-dimeth
Autor:
Ulrich Bierbach, Amanda M. Mounce, Margaret C. Ackley, Russel C. Sequeira, Todd M. Augustus, Suzanne M. Hess
Publikováno v:
Cancer chemotherapy and pharmacology. 56(4)
Recently, we reported a new class of DNA-targeted hybrid platinum-acridine agents. The parent intercalator, ACRAMTU, a 9-aminoacridine derivative, intercalates into the minor groove of DNA, causing the corresponding prototypical conjugate, PT-ACRAMTU