Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Amanda M. Gillum"'
Autor:
Jerome E. Groopman, E. Premkumar Reddy, Ramesh Kumar, Amanda M. Gillum, M.V. Ramana Reddy, Paula M. Kuzontkoski, Evangelos Papadopoulos, Ashutosh Shrivastava, Anil Prasad
PDF file - 100K, Supplementary Methods including: cells, antibodies, preparation of GST-eIF4E and GB1-eIF4E proteins, assessing protein/compound binding by saturation transfer difference (STD) and 1D 1H-NMR spectra, assessing protein/compound binding
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1adeb8c5e6d8ce0cc1c8b9bb159d4b3b
https://doi.org/10.1158/1078-0432.22449836.v1
https://doi.org/10.1158/1078-0432.22449836.v1
Autor:
Jerome E. Groopman, E. Premkumar Reddy, Ramesh Kumar, Amanda M. Gillum, M.V. Ramana Reddy, Paula M. Kuzontkoski, Evangelos Papadopoulos, Ashutosh Shrivastava, Anil Prasad
Purpose: Mantle cell lymphoma (MCL) is an incurable B-cell lymphoma, and new therapeutic strategies are urgently needed.Experimental Design: The effects of ON 013105, a novel benzylstyryl sulfone kinase inhibitor, alone or with doxorubicin or rituxim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66b35c013c6f60a5dccf48b6c5ed65b4
https://doi.org/10.1158/1078-0432.c.6521768.v1
https://doi.org/10.1158/1078-0432.c.6521768.v1
Autor:
Jerome E. Groopman, E. Premkumar Reddy, Ramesh Kumar, Amanda M. Gillum, M.V. Ramana Reddy, Paula M. Kuzontkoski, Evangelos Papadopoulos, Ashutosh Shrivastava, Anil Prasad
PDF file - 619K, Pharmacokinetic analysis of ON 013105 in mice after various routes of drug delivery
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09aa4619659ee55217d74ff9a8b02ce8
https://doi.org/10.1158/1078-0432.22449839.v1
https://doi.org/10.1158/1078-0432.22449839.v1
Publikováno v:
Oncotarget
// Anil Prasad 1 , Nagina Khudaynazar 1 , Ramana V. Tantravahi 2 , Amanda M. Gillum 2 , Benjamin S. Hoffman 2 1 Division of Experimental Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA 2 Onconova Therapeu
Autor:
Ramesh Kumar, M. V. Ramana Reddy, Ashutosh Shrivastava, E. Premkumar Reddy, Paula M. Kuzontkoski, Evangelos Papadopoulos, Anil Prasad, Amanda M. Gillum, Jerome E. Groopman
Publikováno v:
Clinical Cancer Research. 19:85-95
Purpose: Mantle cell lymphoma (MCL) is an incurable B-cell lymphoma, and new therapeutic strategies are urgently needed. Experimental Design: The effects of ON 013105, a novel benzylstyryl sulfone kinase inhibitor, alone or with doxorubicin or rituxi
Publikováno v:
Antisense and Nucleic Acid Drug Development. 12:193-213
The components of the apoptotic program are targets for anticancer therapy. Bcl-2 protein inhibits apoptosis and confers resistance to treatment with traditional cytotoxic chemotherapy, radiotherapy, and monoclonal antibodies (mAb). Oblimersen sodium
Autor:
Paul V. Kaplita, Vincent Marinelli, David M. Sedlock, Christopher C. Chadwick, Joseph J. Oleynek, Hao H. Sun, Colin J. Barrow, Raymond Cooper, Amanda M. Gillum
Publikováno v:
The Journal of Antibiotics. 50:729-733
A related group of compounds belonging to the antimycin class of antibiotics was found in culture broth produced by a Streptomyces species. The group includes known antimycins A1, A2, A3 and A4, and new antimycins A7 and A8. These compounds inhibit A
Autor:
Paul V. Kaplita, Mary B. Stawicki, David R. Houck, Robert C. Wahl, Hao H. Sun, Amanda M. Gillum, Raymond Cooper, Ruthann McGarry
Publikováno v:
Phytotherapy Research. 10:194-197
In our natural products screening programme for the discovery of competitive inhibitors of the matrix metalloproteinases, stromelysin and collagenase, we have isolated an active compound, betulinic acid (1), from the plant Doliocarpus verruculosus. B
Autor:
David M. Sedlock, Christopher C. Chadwick, Michael P. Burns, Colin J. Barrow, Amanda M. Gillum, Paul V. Kaplita, Joseph J. Oleynek, Hao H. Sun, Dennis J. Murphy, Raymond Cooper
Publikováno v:
Drug Development Research. 36:35-42
Adenosine triphosphate (ATP)-citrate lyase (ACL) is a homotetrameric liver enzyme which catalyzes the cytosolic formation of acetyl-CoA. This reaction provides the major source of acetyl-CoA for fatty acid and cholesterol biosynthesis. Inhibition of
Autor:
Amanda M. Gillum, Xing Shen, Mahmut Miski, Terry J. Higgins, Raymond Cooper, Diana K. Fisher, Richard W. Miller
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 5:1519-1522
Using a high throughput colorimetric bioassay three aporphine alkaloids, annonaine, nornuciferine and roemerine, were isolated and identified as the CD45 protein tyrosine phosphatase inhibitor metabolites of Rollinia ulei . The nor-aporphine alkaloid