Výsledky vyhledávání - "Amanda M. Branam"

Intersection of AHR and Wnt Signaling in Development, Health, and Disease

Autor: Amanda M. Branam, Andrew J. Schneider, Richard E. Peterson

Publikováno v: International Journal of Molecular Sciences, Vol 15, Iss 10, Pp 17852-17885 (2014)
International Journal of Molecular Sciences

The AHR (aryl hydrocarbon receptor) and Wnt (wingless-related MMTV integration site) signaling pathways have been conserved throughout evolution. Appropriately regulated signaling through each pathway is necessary for normal development and health, w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a4fd1b77d5a14dcf06b206a06c3937f
http://www.mdpi.com/1422-0067/15/10/17852

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2,3,7,8-Tetrachlorodibenzo-p-dioxin has both pro-carcinogenic and anti-carcinogenic effects on neuroendocrine prostate carcinoma formation in TRAMP mice

Autor: Tien Min Lin, Richard E. Peterson, Robert W. Moore, Andrew J. Schneider, Stephen Safe, Amanda M. Branam, Wayne A. Fritz

Publikováno v: Toxicology and applied pharmacology. 305

It is well established that the prototypical aryl hydrocarbon receptor (AHR) agonist 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) can both cause and protect against carcinogenesis in non-transgenic rodents. But because these animals almost never develo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65446a3e8bd8724560702657ef0d3836
https://pubmed.ncbi.nlm.nih.gov/27151233

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Zebrafish chordin-like and chordin are functionally redundant in regulating patterning of the dorsoventral axis

Autor: Francisco Pelegri, Guy G. Hoffman, Daniel S. Greenspan, Amanda M. Branam

Publikováno v: Developmental Biology. 341(2):444-458

Chordin is the prototype of a group of cysteine-rich domain-containing proteins that bind and modulate signaling of various TGFβ-like ligands. Chordin-like 1 and 2 (CHL1 and 2) are two members of this group that have been described in human, mouse,

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Characterization of the six zebrafish clade B fibrillar procollagen genes, with evidence for evolutionarily conserved alternative splicing within the pro-α1(V) C-propeptide

Autor: Amanda M. Branam, Daniel S. Greenspan, Guorui Huang, Francisco Pelegri, William G. Cole, Richard M. Wenstrup, Guy G. Hoffman

Publikováno v: Matrix Biology. 29:261-275

Genes for tetrapod fibrillar procollagen chains can be divided into two clades, A and B, based on sequence homologies and differences in protein domain and gene structures. Although the major fibrillar collagen types I-III comprise only clade A chain

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0ca4cb2eb736b0f40b772e0f136b742
https://doi.org/10.1016/j.matbio.2010.01.006

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Bone Morphogenetic Protein 1 Prodomain Specifically Binds and Regulates Signaling by Bone Morphogenetic Proteins 2 and 4

Autor: Amanda M. Branam, Nikolas G. Voss, Francisco Pelegri, Gaoxiang Ge, Reema Jasuja, Daniel S. Greenspan, Jamie Lyman-Gingerich

Publikováno v: Journal of Biological Chemistry. 282:9053-9062

Highly purified fractions of bone extracts capable of inducing ectopic bone formation have been reported to contain peptides corresponding to the mature active regions of the TGF-beta-like bone morphogenetic proteins (BMPs) 2-7, and to the prodomain

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86a646a468c6b572cdc30fd24a0315ca
https://doi.org/10.1074/jbc.m610929200

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In Utero Exposure to TCDD Alters Wnt Signaling During Mouse Prostate Development: Linking Ventral Prostate Agenesis to Downregulated β-Catenin Signaling

Autor: Richard E. Peterson, Chad M. Vezina, Vatsal Mehta, Kimberly P. Keil, Amanda M. Branam, Lisa L. Abler, Robert W. Moore, Andrew J. Schneider

In utero exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) causes ventral prostate agenesis in C57BL/6J mice by preventing ventral prostatic budding in the embryonic urogenital sinus (UGS). TCDD (5 μg/kg, po) administered to pregnant dams on em

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df90ac86d14b3b9429d75cbe5c6e6d33
https://europepmc.org/articles/PMC4271122/

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TCDD inhibition of canonical Wnt signaling disrupts prostatic bud formation in mouse urogenital sinus

Autor: Chad M. Vezina, Andrew J. Schneider, Richard E. Peterson, Amanda M. Branam, Nicole M. Davis, Robert W. Moore

Publikováno v: Toxicological sciences : an official journal of the Society of Toxicology. 133(1)

In mice, in utero exposure to 2,3,7,8-tetrachlorodibenzo-p- dioxin (TCDD) reduces the number of dorsolateral prostatic buds resulting in a smaller dorsolateral prostate and prevents formation of ventral buds culminating in ventral prostate agenesis.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca1111982def41e59d6417c81c424c49
https://pubmed.ncbi.nlm.nih.gov/23429912

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Wnt inhibitory factor 1 (Wif1) is regulated by androgens and enhances androgen-dependent prostate development

Autor: Pinak S. Joshi, Amanda M. Branam, Paul C. Marker, Chad M. Vezina, Rita A. Buresh-Stiemke, Christopher T. Schmitz, Kimberly P. Keil, Lisa L. Abler, Vatsal Mehta

Publikováno v: Endocrinology. 153(12)

Fetal prostate development from urogenital sinus (UGS) epithelium requires androgen receptor (AR) activation in UGS mesenchyme (UGM). Despite growing awareness of sexually dimorphic gene expression in the UGS, we are still limited in our knowledge of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0865f2119dd4a63dfd57f04c59bb072d
https://pubmed.ncbi.nlm.nih.gov/23087175

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